"I-Lorista" (amaphilisi): incwadi yokufundisa, ukubuyekezwa, ukufana

Imakethe yemithi igcwele izidakamizwa ukunciphisa ukucindezeleka kwegazi. Phakathi kwabo kukhona abaphikisi be-receptors ye-angiotensin enzyme.

Ukuhluka kwezidakamizwa

Isidakamizwa esithi "Lorist" sitholakala ezinhlobonhlobo eziningana: ngesimo sokulungiselela okukodwa "Lorista", amafomu ahlanganisiwe "i-Lorist N" no-"Lorist ND", ehluke kumthamo wezinto ezisebenzayo. Amafomu amabili ayingxenye yesidakamizwa anomthelela omncane futhi abe nomthelela omuhle.

Ukwakhiwa

Amaphilisi e-"Lorist" okulungiselelwa okukodwa ayatholakala ezinyangeni ezintathu ezinezinto ezisetshenziselwa ukusetshenziswa kwe-losartan potassium at 12.5 mg, 25 mg, 50 mg. Njengamakhemisi asizayo, ummbila nesitashi esandulele, i- microcrystalline cellulose, ingxube ye-lactose ne-cellulose, i-aerosil, i-magnesium stearate isetshenziswa. I-membrane yefilimu yezilinganiso zika-25 mg noma 50 mg we-potassium losartan iqukethe i-hypromellose, i-talc, i-propylene glycol, i-titanium dioxide, futhi idayini e-yellow quinoline iyasetshenziselwa umthamo we-12.5 mg.

Amathebulethi amalungiselelo "Lorista N" no "Lorista ND" ayenomqondo oyigugu kanye negobolondo. Ingqikithi iqukethe izingxenye ezimbili ezisebenzayo: i-potassium losartan 50 mg (ifomu le-H) kanye ne-100 mg (ye-ND amafomu) kanye ne-hydrochlorothiazide ku-12.5 mg (ifomu "H") no-25 mg (ifomu "ND"). Ukwenza ingqikithi, izakhi ezengeziwe zisetshenziswe ngesitashi esandulele, i-microcrystalline cellulose, ishukela lebisi, i-magnesium stearate.

Amaphilisi "uLorista N" no "Lorista ND" afakwe i-membrane yefilimu equkethe i-hypromellose, i-macrogol 4000, i-quinoline idayi ephuzi, i-titanium dioxide ne-talc.

Indlela umuthi usebenza ngayo

Isidakamizwa esincintisana kakhulu (izidakamizwa "i-Lorista") imfundo ichaza isenzo semithi yesigaba ngasinye esisebenzayo.

Enye yezinto ezisebenzayo i-losartan, esebenza njengomphikisi ophikisayo we-enzyme ye-angiotensin hlobo 2 kuma-receptors wesakhiwo esingewona amaprotheni.

Izifundo ezenziwe nge-vitrovic nasezilwaneni zezilwane ziye zaveza ukuthi isenzo se-losartan ne-carboxyl metabolite yaso sihlose ukuvimbela imiphumela ye-angiotensin kuma-receptors angiotensin hlobo 1. Lokhu kuvuselela i-renin eplasma yegazi futhi kubangele ukwehla kwe-aldosterone egazini legazi.

Okubangela ukwanda kokuqukethwe kwe-angiotensin uhlobo lwesi-2, i-losartan ivuselela ama-receptors ale-enzyme, ngenkathi ngesikhathi esifanayo ingashintshi umsebenzi we-enzyme kininase type 2, ehileleke ekushintsheni kwe-bradykinin.

Isenzo senxenye esebenzayo yesidakamizwa "i-Lorist" ihloswe ukunciphisa ukuphikiswa komzimba kombhede wamasongo, ukucindezelwa ezitsheni zendiza encane yokujikeleza kwegazi, i-postnagruzka, ukuhlinzeka ngomphumela wokudla.

U-Lozartan akavumeli ukukhulisa ukwanda kwamathambo emisipha yenhliziyo, kwandisa ukumelana nomzimba womzimba womzimba, onokukhubazeka kwenhliziyo okungapheli.

Ukusetshenziswa kwansuku zonke kwesilinganiso esisodwa se-losartan kubangela ukuncipha okuqhubekayo emshinini wegazi ophezulu (systolic) nephansi (diastolic). Phakathi nosuku, ngaphansi kwethonya lale nto, umfutho wegazi ulawulwa ngokufanayo, futhi umphumela we-antihypertensive uhambelana nesigqi semvelo. Ukuncipha kwengcindezi ekupheleni kwesilinganiso se-losartan kwenzeka ngo-80% uma kuqhathaniswa nokuphakama komsebenzi wesithako esisebenzayo. Lapho ukwelashwa umuthi ithonya lokushaya kwenhliziyo alibonakali, futhi ekuqedeni izibonakaliso zokuthola isifo sokukhishwa kwesilungiselelo akuhlakuleli. Ukusebenza kwe-losartan kudluliselwa emzimbeni wesilisa nowesifazane oneminyaka yonke.

Ngokuhlanganiswa kwezidakamizwa, isenzo se-hydrochlorothiazide njenge-thiazide diuretic lihlotshaniswa nokukhathala okungafaneleki kwe-chlorine, i-sodium, i-magnesium, i-potassium namanzi kumchamo oyinhloko emuva kwegazi le-nephron eliphakathi kwe-nephron. Isidakamizwa sithuthukisa ukugcinwa kwe-calcium ne-uric acid nge-ion. I-Hydrochlorothiazide ibonisa izindawo ezinamagciwane amakhulu ngenxa yokwanda kwe-arterioles. Umphumela wokuzibulala uqala ngemuva kwemizuzu engu-60-120, futhi umphumela omkhulu we-diuretic uhlala emahoreni angu-6 kuya kwangu-12. Umthelela omuhle we-antihypertensive ukwelashwa nomuthi ufika enyangeni engu-1.

Kungani usebenzise

Isidakamizwa esithi "Lorista", amaphilisi, imiyalelo yokusetshenziswa iphakamisa ukusetshenziswa kwe:

• Ukuze ukwelashwa kwesifo somfutho wegazi, lapho ukwelashwa okuhlangene kuboniswa khona;
• Ukunciphisa amathuba okugula kwesimiso senhliziyo kanye nenani labantu abafayo abahambisana ne- hypertension kanye nezinguquko ze-pathological engxenyeni engakwesokunxele.

Indlela yokusebenza

Lo muthi uhloselwe ukusetshenziswa komlomo. Ukudla ukudla akuthinti isenzo semithi. Amathebulethi avela ngaphansi kwengcindezi ethi "Lorista" ingahlanganiswa nezidakamizwa ezinamandla. Ukudla ukudla akuthinti isenzo semithi.

Esikhathini sezidakamizwa "i-Lorista" (amaphilisi), imfundo yokusetshenziswa inezincomo zokufaka ifomu elilodwa lenkampani, inhlanganisela "H" ne "ND". Kuzo zonke izinhlobo zemithi, isisindo sokuqala nesondlo ekucindezelekeni okuphakeme yi-tablet eyodwa kanye ngosuku. Ukunciphisa ukucindezeleka okuphezulu kugcinwa emva kwamasonto amathathu kusukela ekuqaleni kokulashwa. Ukuze kutholakale umphumela omkhulu, kuvunyelwe ukwandisa umthamo wansuku zonke wesidakamizwa "Lorista N" kuya kumaphilisi amabili nge-1 yokuthola. Ngolunye usuku inani elivumelekile lamathebulethi elinesilinganiso se-50 / 12.5 mg yizingcezu ezimbili.

Uma kungekho mthelela wokwelapha okwanele wokuthatha umuthi "Lorista N", bese kuthi umuthi "Lorista ND", amaphilisi anqunywe. Imfundo yale thuluzi ihlanganisa ulwazi ngesilinganiso esiphezulu sesilinganiso esikhulu (100/25 mg) ngosuku, esingekho ngaphezu kwethebhulethi elilodwa.

Lapho umthamo wegazi ojikelezayo ngokusebenzisa lezi zitsha wehla, ngenkathi ukwelashwa ngezinga eliphakeme lokudonswa kwezidakamizwa, umthamo wokuqala we-losartan ungama-25 mg ngesikhathi. Ngakho-ke, ukwelapha nge-agent enjalo yokulwa negciwane kungenzeka kuphela emva kokukhipha izakhi zokudonswa kwe-diuretics nokuvamisa ivolumu yegazi.

Esikhatsini semithi "Lorista" (amaphilisi), imfundo ayinayo ulwazi ngesidingo sokulungisa umthamo weziguli asebekhulile kanye nabantu abalawulwa yi-hemodialysis, noma kulabo abanezinkinga zokuqeda izinkukhu benesidingo se-creinine kusuka ku-30 kuya ku-50 ml ngomzuzu.

Ukunciphisa amathuba okugula kwesimiso senhliziyo kanye nenani lemiphumela ebulalayo emfuthweni wegazi ophezulu kanye nezinguquko ze-pathological kwi-ventricle engakwesobunxele, isilinganiso esilinganiselwe sokuqala se-losartan ngosuku siklanyelwe ku-50 mg ngomthamo ngamunye. Uma imiphumela yokunciphisa ukucindezelwa kwegazi emndenini wokuqala ungakutholakali, kudingekile ukuthi ukwandisa kuya ku-100 mg we-losartan, okusemandleni okusebenzisa amaphilisi amabili omuthi "Lorista N" noma ithebhulethi engu-1 ye "Lorist ND" ngosuku ngalunye.

Imiphumela emibi

Abanye Iziguli zingase zibe nokubonakaliswa kwemiphumela engathandeki ekwelashweni nalesi sidakamizwa esinamandla okubulala. Uma usebenzisa umuthi "Lorista" (amaphilisi), imiyalelo yokusetshenziswa ihlanganisa uhlu lwemiphumela emibi ehambisana nezinhlelo ezihlukahlukene zomzimba.

Isenzo esimisweni sezinzwa esiyinhloko sibonakala njengenhloko yekhanda, isisindo somzimba nesingenasistimu, ukuleleka, ukukhathala, i-migraine.

Uma kuthinta uhlelo lwe-cardiovascular, umuthi udala i-hypotension-dependent hypotension, i-palpitations, tachycardia, nokuvuvukala kwemikhumbi.

Umphumela ohlelweni lokuphefumula ubonakala ngokukhwehlela, ukutheleleka emkhakheni wokuphefumula, pharyngitis, i-edema yekhanda elimangcwabeni le-nasopharynx.

Uhlelo lokugaya luhlinzeka ngezifo ezinjengokuhuda, i-dyspepsia, i-nausea, ukuhlanza, ubuhlungu besisu, isifo sofuba, ukuhluleka kwesibindi, lapho izinyimba ze-foie kanye ne-bilirubin zishintshiwe.

Kuhlelo lwesishuloskeletal, umphumela ubonakala nge-myalgia, ubuhlungu ngemuva, i-arthralgia.

Ezingxenyeni ze-hematopoietic, umphumela ubonakala nge-anemia ne-purpura.

Izinkomba ezishintshiwe kanye nelabhoratori ezibhekene ne-hyperkalemia, amazinga akhula we-hemoglobin, i-creatinine, i-hematocrit, irea e-plasma yegazi.

Isenzo singahambisana nokuphendula okwenziwe okwenziwa yi-urticaria, ukukhwabanisa isikhumba, ukushuswa kwe-anaphylactic, i- angioedema, i- edema ebusweni, intamo, izingxenye eziphezulu ze-trunk nezitho zomngcele.

Ukungafani

Akuwona wonke umuntu ongaphathwa nge-Lorist. Imiyalo yokusetshenziswa ayincoma ukusetshenziswa kwalesi sidakamizwa ku-anuria, ukuphulwa okuphawulekayo kwezinso zezinso, lapho imvume ye-creatinine ingaphansi kuka-30 ml ngomzuzu.

I-contraindicated in hyperkalaemia, i-hypokalemia engabonakaliyo, ukwephulwa kwamanzi amanzi emzimbeni ngesikhathi sokulashwa okuphezulu kakhulu kwemithi yokuzivocavoca, umsebenzi wesibindi okhubazekile kakhulu, ukwanda kwengcindezi yegazi, ukungabi nelutho kwe-glucose ne-galactose, ukukhulelwa, ukubeletha, izingane kanye nentsha engaphansi kweminyaka engu-18 ubudala .

Ukwelashwa ngezidakamizwa "i-Lorista" (amaphilisi) imfundiso evimbela ukuzwela okwandayo kumakhemikhali ochungechunge lwe-sulfonamide, okuyizinto ezisuka ku-losartan, i-hydrochlorothiazide noma ezingxenyeni ezisizayo zomuthi.

Ukuqapha kuyadingeka uma kusetshenziswa iziguli ezine-balance-electrolyte ephazamisekile egazini, uma kunezibonakaliso ze-alkalosis ye-hypochloremic, i-sodium, i-potassium, i-magnesium encane kanye nokuphakama okuphezulu kwe-i-calcium ions emzimbeni womuntu.

Ukunciphisa kwamagciwane wezinyosi noma ukugxila kwe-artery lumen kuya kwezinso ezilodwa, isifo sikashukela, ukwandisa i-uric acid e-plasma yegazi, ukufakwa kwe-urate emajoyini, ukutholakala kwezidakamizwa ezivimbela ama-enzyme, ama-asthma e-bronchial, izifo zegazi zesistimu zibangele ukuqapha Ukusebenzisa imishanguzo yokulwa namagciwane.

Izici zohlelo lokusebenza

Ngesikhathi ukwelashwa nomuthi "Lorista" (amaphilisi), imfundo yokusetshenziswa ikuvumela ukuba ngaphezu kwalokho uthathe amanye ama-antihypertensives. Kubantu asebekhulile, akukho ukukhethwa okukhethekile kwesilinganiso sokuqala esidingekayo.

Isenzo sesidakamizwa singabangela ukwanda kwe-creatinine ne-urea e-serum yegazi yezigulane ezine-stenosis ebusweni be-artery of the kidneys noma i-stenosis ye-artery of one kidney.

Ngaphansi kwethonya lika-hydrochlorothiazide, i-hypotension ye-arterial yanda, ukulinganisela kwe-electrolyte kuphazamiseka, okubhekiswe ekunciphiseni kwezinga lokujikeleza kwegazi, i-hyponatremia, i-alkalosis ye-hypocloraemic, i-hypomagnesemia, i-hypokalemia. Umphumela we-diuretic uhlose ukwandisa ukuhlushwa kwe-cholesterol kanye ne-triglycerides, ukushintsha ukubekezela komzimba kuma-molecule we-glucose, ukunciphisa i-excretion ye-calcium ions kumchamo, okuholela ekwandeni kwamazinga e-serum. I-Hydrochlorothiazide ingabangela ukucindezeleka kwegazi kanye ne-gout.

Ukwakhiwa kwenhlanganisela kuqukethe ubisi ushukela, ophikisanayo neziguli ezingenayo i-lactase enzyme, ene-galactoseemia noma i-glucose nesifo se-galactose ukungavumi.

Ezimweni zokuqala zokwelashwa nge-agent e-antihypertensive, ukwehla komfutho nokucindezeleka kungase kwenzeke, okuphazamisa umsebenzi we-psychophysical of the organism. Ngakho-ke, iziguli ezinomsebenzi ohlotshaniswa nokunakekelwa kakhudlwana ekuphathweni kwezimoto noma izindlela eziyinkimbinkimbi, kufanele zithole isimo sabo ngaphambi kokuqala imisebenzi yazo.

Ama-analogues

I-JSC "I-Krka, i-dd, i-Novo mesto" yikhiqiza sedakamizwa e-anti-burner "Lorista" (amaphilisi). Ama-analogues alo muthi ekubunjweni kwawo anesici esisebenzayo se-losartan potassium. Amafomu ahlanganisiwe, imithi efanayo iqukethe izingxenye ezimbili ezisebenzayo: i-potassium losartan ne-hydrochlorothiazide.

Ukuze umuthi "i-Lorista" i-analog izoba nomthelela owodwa we-antihypertensive nemiphumela emibi efanayo. Enye ikhambi elinjalo imithi "Cosaar", amaphilisi ama-50 noma 100 mg we-losertan potassium. Umkhiqizi ngumkhankaso we-Merck Sharp ne-Doum BV, eNetherlands.

Ngamafomu ahlanganisiwe, isifaniselo yiGisaar neGisaar Fort. Umkhiqizi nguMerck Sharp noDoum BV, eNetherlands. Amaphilisi omuthi we-dosage ephansi ahlanganiswe negobolondo eliphuzi elimhlophe, enebheji "717" kwenye yezindawo ezikhona futhi engozini yokuhlukanisa ngakolunye uhlangothi, futhi amaphilisi e-oval of dosage ephakeme ahlanganiswe negobolondo elimhlophe elibizwa ngokuthi "745" ngakolunye uhlangothi.

Ukwakhiwa kwesidakamizwa "iGisaar Fort" kuhlanganisa i-losartan potassium ngenani lika-100 mg ne-hydrochlorothiazide, eliqukethe 12.5 mg. Ukwakhiwa kwesidakamizwa esithi "Gisaar" kufaka i-losartan potassium ngenani lika-50 mg ne-hydrochlorothiazide, equkethe 12.5 mg.

Ngokuphambene nomuthi "Lorista ND", umuthi "iGisaar Fort" uqukethe isigamu se-hydrochlorothiazide, futhi okuqukethwe kwe-losertan potassium kuyavumelana. Zombili izidakamizwa zinezenzo ezinamandla kakhulu ezinomthelela omncane wezitho zomzimba.

Enye i-analogue ehlanganisiwe yikhiqiza "Lopaz plus" ekhishwe yiZentiva njenge-Czech Republic. Ikhiqizwa ngesimo samathebulethi oblong engcupheni ezindaweni zombili, ezigcwele ifilimu ephuzi eliphuzi. Imithi iqukethe i-potassium losartan ngenani lika-50 mg ne-hydrochlorothiazide, equkethe 12.5 mg.

Isidakamizwa esifanayo se "Lorist N" yisidakamizwa esithi "Vazotens N", esakhiwe "namaqembu ase-Aktavis ao", e-Iceland. Itholakala ezinyangeni ezimbili. Emaphilisi amancane, ama-50 mg we-potassium losartan kanye no-12.5 mg we-hydrochlorothiazide aqukethwe, futhi amaphilisi anesilinganiso esiphezulu aqukethe 100 mg we-potassium losartan no-25 mg we-hydrochlorothiazide.

Ukubuyekeza

Ukubuyekezwa kwezidakamizwa "i-Lorista" kuhlukile. Ezinye iziguli zibika ukuthuthukiswa kwezigaba zokuqala zokwelashwa, lapho kunciphisa ukucindezeleka kwegazi. Abanye babone ukwanda kwe-BP kusihlwa noma ukuqubuka komzwelo. Kulesi simo, kufanele ukhansele ukwelashwa nomuthi "Lorista" (amaphilisi). Ukubuyekezwa kweziguli ze-Instruction kuhlanganiswe esigabeni esithi "Imiphumela Yecala", ekhombisa zonke izenzakalo ezimbi ezingenzeka ezirekhodiwe ngokusetshenziswa kwalesi sidakamizwa esingenamandla.

Isidakamizwa esithi "Lorist" sithathwa nsuku zonke, sisebenzisa isilinganiso esincane, ekugcineni senyuka ngenxa yokulutha komzimba kwento esebenzayo. Umphumela wokwelashwa awubonakali ngokushesha, kodwa njengoba umuthi uqoqwe emzimbeni.