"I-Bronhobos" (isiraphu): imiyalo yokusetshenziswa, izibuyekezo, ama-analogs, amanani

Ngabe umthamo uwuphi umuthi "i-Bronhobos" (isiraphu) enqunyiwe? Imiyalelo yokusetshenziswa kwezidakamizwa ze-mucolytic ichazwa ngokuningiliziwe ngezansi. Kanti futhi ezintweni ezikulesi sihloko ungathola ulwazi mayelana nezinhloso ezisetshenziswa ngayo imithi, kungakanani okubiza, kungakhathaliseki ukuthi kunemiphumela emibi, ukufana nokulinganisa.

Ukwakhiwa nokupakisha

Kukuphi okufakwe ku-Bronchobos (isiraphu) ethengiswa? Imiyalelo yokusetshenziswa kwe- agent e-mucolytic ifakwe emphakathini wekhadibhodi, lapho kutholakala khona i-spost yokulinganisa ye-polystyrene enelebula, kanye nebhodlela leglasi elimnyama elinesihenqo esine-aluminium, ene-sealant, indlela yokuzivikela kanye nokulawula kokuvula kuqala.

Into esebenzayo yalesi sidakamizwa i-carbocysteine. Iqukethe nezinhlanganisela ezisizayo ngendlela ethanol, glycerol, sodium hydroxide, citric acid monohydrate, carmellose sodium, methylparahydroxybenzoate, propyl parahydroxybenzoate, saccharinate sodium, azorubin, okusajingijolo namanzi ahlanzekile.

I-"Bronhobos" isiraphu, echazwe ngezansi, i-2.5% noma u-5% ukulungiselela okusobala, okuhambisana nokungahambisani kahle, ukunambitheka okusajingijolo nombala obomvu obomvu.

Pharmacodynamics of the izidakamizwa

Izidakamizwa ze-mucolytic, kufaka phakathi isiraphu "i-Bronhobos", inomphumela wokuxhuma. Umphumela walesi sidakamizwa ngenxa yokusebenza kwe-enzyme - ukudluliswa kwe-sialic, okukhiqizwa emasethini omumo wesigqoko embukheni we-bronchial.

Isidakamizwa simisa isilinganiso samanani we-acid, kanye ne-sialomucin engathathi hlangothi ekusithekeni kwe-bronchial. Ngaphezu kwalokho, kubuyiselwa i-viscosity ye-mucus nokuqina kwayo.

Yiziphi ezinye izici ezinezidakamizwa ze-mucolytic? Bakhuthaza ukuvuselelwa kwezinambuzane ezinamanzi, ukuvuselela isakhiwo, futhi kusebenze umsebenzi we-citheary epithelium. Isiraphu ye-Bronhobos ibuyisela ukuvinjelwa kwe-immunoglobulin A njengendlela yokuzivikela ethize, kanye nenani lamaqembu e-sulfhydryl ku-mucus kanye nezingxenye zalo njengesivikelo esingavumelekile. Futhi lesi sidakamizwa sithuthukisa ukuvunyelwa kwe-mucociliary.

Imingcele ye-Pharmacokinetic yalesi sidakamizwa

Isidakamizwa "i-Bronhobos", intengo yayo ezoboniswa ngezansi, ifakwa ngokushesha futhi ngokuphelele. Ngaphezu kwalokho, ine-bioavailability ephansi (ngaphansi kuka-10% we dose ethathwe). Izinga eliphakeme kakhulu le-carbocisteine esebenzayo emangqamuzaneni nasegazi lifinyelelwa emva kokuphela kwamahora angu-1.5-2. Izinga layo lokwelapha liphikelela amahora angu-8. Isidakamizwa eside kakhulu sibambezeleka esibindi, ukugeleza kwegazi kanye nendlebe ephakathi. Ezingxenyeni eziphezulu, iqoqa ekusithekeni kwe-bronchi (cishe ngo-17.5% womthamo othathwe).

Isidakamizwa sihlanganiswe esibindi. Kubonakala ngomphumela wevesi lokuqala. Cishe u-60-90% wemithi ixoshwa yizinso ngendlela engaqinisekisiwe.

Ukuphila kwengxenye yomuthi amahora angu-2-3. I-excretion yayo ephelele ithatha ngemva kwezinsuku ezintathu.

Isiboniso sokusetshenziswa kwesiraphu

Yiziphi izinhloso ze-Bronhobos zezingane nabantu abadala? Ngokweziqondiso, lesi siphuphu sisiza ngokuphumelelayo nge:

• Izinqubo zokuvuvukala ezivela ezonini ze-paranasal kanye nendlebe ephakathi, kuhlanganise nesusitis, i-rhinitis ne-otitis media;
• Izifo ezingapheli futhi ezinzima ze-bronchopulmonary, ezihambisana nokuphulwa kwe-mucus kanye nokufihla (isibonelo, i-bronchitis, i-tracheitis, i-bronchial asthma, i-tracheobronchitis ne- bronchiectasis).

Ngaphezu kwalokhu okushiwo ngenhla, imithi ebuzwayo isetshenziselwa ngempumelelo ngesikhathi ilungiselelo lesiguli se-bronchography noma i-bronchoscopy.

Ukungafani kokusetshenziswa

Kukuphi okushiwo ukuthi akunconywa ukuthatha "i-Bronhobos" (isiraphu)? Imiyalo yokusetshenziswa ikhombisa ukuphikisana okulandelayo kuwo wonke amafomu okulinganisa:

• I-ulcer ye-duodenum nesisu (ikakhulukazi nokukhushulwa);
• Ukuziphendulela komzimba kuya ezingxenyeni zomuthi;
• I-Cystitis ne- glomerulonephritis engapheli (kufaka phakathi ukukhushulwa okukhulu);
• Kudala kuze kube yiminyaka engu-15.

I-2.5% nesiraphu engu-5%:

• Isisu;
• Izifo eziningi zesibindi, utshwala;
• Izifo zesibindi nokulimala kwalesi sitho;
• Ukubeletha nokukhulelwa.

I-2.5% isiraphu:

• Kudala kuze kube yiminyaka engu-3.

Izimo zokusetshenziswa ngokucophelela kwezidakamizwa:

• Ukuba khona kwesilonda se-duodenum nesisu esiswini se-anamnesis.

Ukulungiselela: I-Bronhobos (isiraphu): imiyalelo yokusetshenziswa

Ngokweziqondiso ezifakiwe, le mithi kufanele ithathwe ngomlomo. Umthamo wesidakamizwa kufanele uzimisele ukusebenzisa i-spoon yokulinganisa.

Kubantu abadala, umuthi unqunywe ngesamba esingu-15 ml, okuyi-3 scoops yesiraphu engu-5% (kathathu ngosuku).

Izinsana ezineminyaka engama-3-6 iminyaka engu-2.5% imithi inikezela ama-ml angu-2-4 izikhathi ezingu-2 ngosuku, okungenani inani le-spoon yokulinganisa ukuthola eyodwa.

Izingane ezineminyaka engama-6 zinqunywe u-5-10 ml we-2.5% isiraphu kathathu ngosuku, okungukuthi, 1-2 ama-spoons wokulinganisa.

Ukudlula ngokweqile komuthi

Uma uthatha amanani amaningi isiraphu, isiguli singase sizwe ubuhlungu besisu, isifo sohudo kanye nesicefe. Ukuqeda ukungafani okunjalo kubeka ukwelashwa okuyisimangaliso.

Izenzakalo ezimbi

Ukuthatha imithi "i-Bronhobos" kungabangela imiphumela engathandeki engxenyeni yezinhlaka nezinhlelo ezilandelayo:

• Ipheshana lezinsikazi: ubuhlungu be-epigastric, i-nausea, ukuphuma, ukuhlanza, isifo sohudo.
• Amasosha omzimba: ukusabela okwe-allergen ngesimo se-exanthema, i-urticaria, i-skin itching, i-angioedema.
• Okunye: isizungu, ukubukeka kobuthakathaka, i-malaise.
• Kubantu abane-asthma kanye neziguli ezikhulile, ukuvinjelwa kwamanzi kungase kwenzeke.

Ukusebenzisana kwezidakamizwa

Uma uthatha noma yiziphi izinhlobo zokwelapha izidakamizwa:

• Ukwandisa umphumela we-bronchodilator wezidakamizwa "Theophylline".
• Lapho ukwelashwa kwezinqubo ezithathelwanayo nokuvuvukala emkhakheni ophansi nangaphezulu wokuphefumula, kungase kube nokwanda okwenziwe ekusebenzeni kahle kweglucocorticoid, kanye nomthelela ohlukile we-antibacterial.
• Ngezidakamizwa ezinjenge-atropine, umphumela we-antitussive unobuthakathaka.

Uma uthatha isiraphu:

• Ukunakekelwa okukhethekile (ngenxa yobukhona be-ethanol) kusetshenziswa ngezidakamizwa ezibangelwa umkhuhlane, ukuhlanza, ubomvu kanye ne-tachycardia.
• Ukuqapha okukhulu (ngenxa yokutholakala kwe-ethanol) kuthathwa ngezidakamizwa ezinje njenge "Cefamandol", "Disulfiram", "Cefoperazone", "Latamoxef", "Chloramphenicol", "Glipizide", "Glibenclamide", "Chlorpropamide", iTolbutamide "," Griseofulvin "," Metronidazole "," Tinidazol "," Seknidazol "," i-Ornidazole "," i-Procarbazine "," i-Ketoconazole ".

Izincomo Ezikhethekile

Isiraphu "I-Bronhobos" iqukethe i-ethanol. Ngokuphathelene nalokhu, uqondiswa ngokucophelela izingane kanye nabantu abahlukunyezwa ngokweqile. Ngemuva kokuthatha lesi sidakamizwa ezigulini, ukunakwa kanye nokusheshisa kokuphendula kwengqondo kuyaphazanyiswa. Kulokhu, sebenzisa le mithi ayinconywa kubashayeli bezimoto nalabo abasebenza ngezindlela eziyinkimbinkimbi.

Imigomo yokuthengisa, usuku lokugcina nokuphelelwa yisikhathi

Wathengisa izidakamizwa ezinjalo kuma-pharmacy ngaphandle kwemithi kadokotela. Gcina endaweni engafinyeleleki kubantwana, ukubuka umbuso wokushisa we-16-30 degrees. Impilo yeshefu yesiraphu yiminyaka emithathu (ngaphandle kokuyekethisa ubuqotho bephakheji).

I-Bronchobos: ama-analogues nezindleko

Okwamanje, kunezinhlobo eziningi zezindlela ezicatshangwayo. Okuseduze komsebenzi wesenzo yisidakamizwa esithi "Fluviert" (isiraphu). Kuyinto futhi ehlelekile emcolytic. Ngaphezu kwalokho, umuthi owethulwe ungashintshwa ngezindlela ezifana ne "Fluiditek", "Bronkatar", "Libexin Muko", "Mukopron" no "Mukosol".

Kubiza kangakanani "i-Bronhobo"? Intengo yalo muthi incike esimweni sayo sokukhululwa. Isiraphu engu-5% ingathengwa ama-ruble angu-550-570, no-2.5% wezidakamizwa - ama-ruble angu-420.

Ukubuyekeza mayelana nomuthi

Njengokwalungiselela "Fluviert", isiraphu ye "Bronhobos" iyinhlangano yekhwalithi ephezulu futhi ephumelelayo. Lona umbono owenziwa yiziguli eziningi ezazisisebenzisa le mithi yokwelapha izifo ezingapheli futhi ezinzima ze-bronchopulmonary.

Ngokombono wabanolwazi abanolwazi, lokhu kulungiselelwa kuyakwazi ukuhlanza ngokushesha nangokuphumelelayo, kanye nokuhoxisa i-phlegm kusuka ku-bronchi. Okunye okunye kwalolu thuluzi ukuthi kunganikwa izingane ezincane kusukela eminyakeni emibili, njengoba kuboniswe izibuyekezo eziningi. Lokhu kubangelwa ukuthi isiraphu esibuzwayo cishe ayinayo imiphumela emibi kanye nokuphikisana.

Ngokuqondene nokubuyekezwa okungahambi kahle, ngokuvamile kuvame ukuhlotshaniswa nenani lemithi yokucolisa. Kodwa-ke, ochwepheshe bemithi bathi izindleko zalolu remedy zifaneleke ngokugcwele, ngoba ingenye yemithi ephumelelayo kakhulu ngokumelene nezifo ze-bronchopulmonary.