"Fliksotid": yokusetshenziswa, ukubuyekezwa. izidakamizwa analogue

Ingabe uyazi ukuthi lesi sidakamizwa "Fliksotid" wayesho ukuthini? Yokusetshenziswa zomuthi, izinkomba yayo, ukwakheka, side effects kanye ifomu ukukhululwa uzobe zichazwe ngokuningiliziwe ngezansi. Ngaphezu kwalokho, sizokutshela mayelana nokuthi kukhona Izimo kwezimali ukuthi kuzoba umcimbi ngokweqile, Nokho it has izakhiwo kwemithi, nokunye.

Ukwakheka kanye nefomu wokukhulula izidakamizwa

Ngayiphi ifomu ungakwazi ukuthenga izidakamizwa "Fliksotid" yokusetshenziswa okufanele ezizofakwa luhlobo? Okwamanje, izidakamizwa kuphela edayiswa ngesimo aerosol ephefumula. The main izidakamizwa esebenzayo fluticasone propionate mikroionizirovanny. izidakamizwa sihlanganisa enjalo ikhomponethi ezengeziwe njengoba tetrafluoroethane.

Ikhishwa nomuthi metal nesifutho elinendawo phansi ngilugweda kanye nedivayisi metering ifakwe sprayer. Ngaphakathi yokuqukethe ekumisweni omhlophe noma awube mhlophe. With ukuthengwa amathuluzi, qiniseka ukuba banake kobuso nesifutho. valve yakhe akumelwe obungefani ebonakalayo.

Izinhlobo izidakamizwa aerosolized

Kuye ngezinga elingakanani isithako esebenzayo elikhona ukumiswa, kunezinhlobo ezintathu omelelwa nomuthi. Amagama abo ufunde kanje: ". Flixotide Evohaler" "Flixotide discus", "Fliksotid Nebula" futhi

Izimfanelo kwemithi zomuthi

Uyini izidakamizwa "Fliksotid"? Yokusetshenziswa uthi isici yayo asebenzayo libhekisela eqenjini GCS imiphumela yendawo. Lapho kuphethwe ephefumula ketshezi asebenzayo zinemiphumela evelele antiallergic futhi antiinflammatory. Ngenxa yalokho, ngokuphawulekayo encishisiwe kobukhulu izimpawu, kanye ukuvama exacerbations pathologies ephelezelwa umgudu isimiso (isb, ukucinana kwemigudu yokuphefumula okungamahlalakhona, isifuba somoya kanye ne-emphysema).

Isimiso ezisebenza zomuthi (aerosol)

Kanjani lesi sidakamizwa "Fliksotid Nebula" nezinye izinhlobo lokhu izidakamizwa? Ingqikithi eziyisisekelo ekuvimbeleni insika cell ayanda, ama-macrophage, eosinophils, ama-neutrophil nama-lymphocyte kanye kunciphisa ukukhiqizwa nokukhululwa mediators ukuvuvukala kanye nezinye izinto eziphila abakhuthele (ezifana histamine, prostaglandin, leukotriene, a cytokine).

Ngo ezingamahlalakhona obstructive isifo samaphaphu okusezingeni eliphezulu ngempumelelo imiphumela yalolu isidakamizwa isitho umsebenzi umgudu wokuphefumula, kube nezimpawu isifo akuzona njengoba evelele, imvamisa nobukhali exacerbations kuyehla, futhi asikho isidingo ukuthatha amaphilisi extra GCS. Ngenxa yalokho, it kwandisa izinga lempilo isiguli.

isinyathelo lefundo zomuthi uzwakalise kancane. Kule ndaba, ngemithamo zokwelapha, ke kwadingeka cishe akukho umphumela ku-eksisi hypothalamic-pituitary-adrenal.

Nomuthi "Fliksotid", okuyinto analogue uzobe okuthiwa ngezansi, ngokushesha ubuyisela impendulo lesiguli bronchodilators, ukunciphisa imvamisa yokusetshenziswa yabo.

Umthelela zokwelapha emva isicelo se-nesifutho aerosol iqala zingakapheli izinsuku futhi ifinyelela esiphezulu amasonto amabili noma ngaphezulu. Umphumela kugcinwa izinsuku ezimbalwa emva ukuqedwa zomuthi.

I pharmacokinetics ejenti aerosolized

Ngemva aerosol "Fliksotid" liye lasetshenziswa inhloso yazo, bioavailability elingaphezu kukahhafu we ketshezi esebenzayo 8-11%.

Lefundo izidakamizwa ukumuncwa kwenzeka ngokuyinhloko emaphashini. By the way, ekuqaleni ukumuncwa Kwenziwa ngokushesha bese kubambezela. Ngesikhathi inqubo, ingxenye ukumiswa imuncwe kungenziwa okugwinywe nesineke. Nokho, ukuchayeka yayo letindzala incane ngenxa solubility abampofu zomuthi emanzini, kanye umzimba olunzulu lapho sidlula kwesibindi.

Plasma amaprotheni yokubopha izidakamizwa ngesikhathi okusezingeni eliphezulu ngokulinganisela futhi imayelana 91%. izidakamizwa Active is akheka e element isibindi ezihilela CYP3A4. Ngenxa yalokho, metabolites ngasebenzi akhiwa.

Nomuthi "Fliksotid" okuyinto ikakhulukazi wokubuyekezwa okuvumelekile, has a kahle eliphezulu plasma imvume. Phakathi nengxenye-ukuphila salo amahora mayelana 8. Lokukhipha ke njengoba metabolites umchamo.

Izinkomba ngokusetshenziswa aerosol izindlela

Kwezinye izimo, baphendukela "Fliksotid" izidakamizwa? Imiyalelo imibiko isicelo ngokuthi umuthi lomisiwe nokwelashwa kweziguli abaphethwe isifuba somoya, ogeleza ifomu esindayo noma okusesilinganisweni. Futhi, nomuthi isetshenziselwa ekuvimbeleni ukuhlasela lapho ithola corticosteroids letindzala.

Ngaphezu kwalokho, i-nomuthi kuboniswa in iziguli nesifo samaphaphu. Yisebenzise ukunciphisa isimiso bronchial, kanye ekuthuthukiseni ukupholisa kwezitho zokuphefumula.

Izimo ukusetshenziswa aerosol izindlela

Ngaphansi yimiphi imibandela noma kunjalo ayikwazi ukusetshenziswa nesifutho 'Flixotide'? Izimo kukhona lezi zinto ezilandelayo:

• hypersensitivity isiguli iyiphi ingxenye nomuthi;
• bronchospasm acute;
• isimo somoya (njengendlela yokuthola lokuqala);
• enyakeni 1.

Kufanele kuqashelwe ukuthi le izidakamizwa akuyona efiselekayo ukuyisebenzisa ukuze ngempumuzo ukuhlaselwa kwakhe isifuba somoya.

Ukusetshenziswa kwesivuno ngokuqikelela izidakamizwa

izidakamizwa "Fliksotid" abamiselwe kakhulu ngokucophelela ngaphansi kwaziphi izimo? Izibuyekezo odokotela bathi ithuluzi kudingeka lisetshenziswe ngaphansi ochwepheshe lilawulwa ngokuqinile ukufiphala isibindi sibe sesomile, isifo sofuba yamaphaphu, i-hypothyroidism, ukukhulelwa, izifo letindzala (webhaktheriya, fungal, yisinanakazana noma viral) kanye lactation kwamathambo.

Izidakamizwa "Fliksotid" ephefumula: imfundo

Kuye uhlobo lomkhiqizo, umsebenzi wako umthamo ingahluka kakhulu. Ngokwesibonelo, ukuze sifinyelele umphumela oyifunayo, fafaza 'Flixotide discus "kumele kusetshenziswe njalo, ngisho naphakathi ukuthethelelwa.

Isikhathi yokwelapha kanye umthamo kahle le izidakamizwa kufanele ukuchaza udokotela kuphela, ikhumbula isimo lesiguli kanye jikelele isithombe emtholampilo. Kubantu abadala, umthamo kuyinto 100-1000 mg izikhathi 2 ngosuku. Ukusetshenziswa kwezidakamizwa uqale amavolumu ubuncane ukuthi ukukhiqiza nomphumela oqabulayo. Uma kudingekile, inani izidakamizwa idliwe zingandiswa. Umthamo esiphezulu kumele singeqi 2000 micrograms.

Nomuthi "Fliksotid" izingane kusukela eminyakeni 4 ubudala abaphethwe somoya bronchial, inikezwa ngenani 50-100 mg kabili ngelanga. Uma kudingeka, lokhu umthamo liyakhula kancane kancane kuze kube micrograms 400 ngosuku. Njengoba abadala nge nesifo samaphaphu ngokuvamile, anikezwa 500 mg zomuthi kabili ngosuku.

Indlela yokusebenzisa lesi sidakamizwa "Flixotide Evohaler"?

Leli thuluzi kufanele asetjenziswe njalonjalo. kunconywa fafaza izikhathi eziningana ngaphambi kokufaka isicelo imithi ukuze kutholakale isilinganiso iyunifomu. Futhi, slurry kuyadingeka ukuze kuqathake ibhodlela. Lapho sishaye aerosol isiguli iyadingeka ukushaya umoya kancane. Isetshenziswa kufanele ahlanze okungenani kanye ngesonto.

Indlela yokusebenzisa lemali Kunconywa imithi "Fliksotid"? Ukweqiwa izidakamizwa ibalwa kanje: eyodwa-off lemali zomuthi elihambisana sputtering ezimbili.

Ngo bronchial somoya abadala ukhombe 100-1000 micrograms lomcebo asebenzayo kabili ngosuku. Ukusetshenziswa imithi kufanele uqale nge amazinga okukhishwa ongaphakeme ngempumelelo, vposlestvii, uma kunesidingo, bona zingandiswa. Inani eliphelele izidakamizwa kumele kube 2000 micrograms.

Indlela esiphatha ngayo izingane ukusebenzisa spray "Fliksotid"? Inhalation izingane eminyakeni emine njengesifuba somoya nalesi sifo, babelwa e inani 50-100 mg kabili ngelanga. Uma kudingeka, umthamo kungenziwa kancane kancane. Inani eliphelele ukusetshenziswa zomuthi izingane eminyakeni emine ubudala kuyinto mg 400.

Abadala okungamahlala obstructive yamaphaphu isifo izidakamizwa ukhombe micrograms 500 kabili ngelanga. Uma emva 3-6 emva Ukuqalwa yokwelapha izinyanga ukuthuthukisa ningagcini, kubalulekile ukuba ukushintsha uhlobo lwemithi yokwelapha.

Uma ingane abaneminyaka ephakathi kwengu-1 no-4 ubudala ukuthi nginesifo isifuba somoya, it is ebekiwe mg 100 zomuthi kabili ngosuku. Kulokhu, lapho ephefumula Kunconywa ukusebenzisa Spicer ezingane enegama ezithakazelisayo "Bebihaler".

Aerosol "Fliksotid Nebula": yokusetshenziswa

Lokhu nomuthi ingasetshenziswa setemlomo (nge isetshenziswa) noma acinene (phambili imaski) ephefumula. Futhi, izidakamizwa ngokuvamile eyabizwa ngokuthi nebulizer aerosol jet. Kuyinto efiselekayo kakhulu ukusebenzisa amadivaysi ultrasonic.

Uma wayefisa ekuphathweni isekelé ejenti noma ukuphathwa ngemithamo ezincane we nomuthi ngaphambi izinqubo ephefumula Kunconywa ikhambi alulaze of sodium chloride.

Abadala futhi intsha engaphezu kwengu-16 izidakamizwa yaphathwa imali 0.5-2 mg kabili ngelanga. Umthamo esiphezulu kufanele ilandelwe ngeviki ngemva kokuhlaselwa yinhliziyo yesifuba somoya, bese kancane kancane ukunciphisa ke.

Uma umphumela ekuthuthukiseni isimo futhi ake aphuma izidakamizwa "Fliksotid Nebula", lapho imfundo njalo kuziwa nezinye izinhlobo izidakamizwa.

Ingane kusukela eminyakeni 4 kuya 16 nomuthi yaphathwa isamba 1 mg kabili ngelanga.

amacala ukweqisa izidakamizwa

Endabeni ka ukweqisa izidakamizwa, isiguli bangezwa ukucindezelwa okwesikhashana ukusebenza ohlelweni hypothalamic-pituitary-adrenal, ukucindezelwa abalulekile womsebenzi adrenocortical, acute crisis adrenal ezinganeni abathola umthamo 1000 mg ngosuku noma ngaphezulu.

Ngaphezu kwalokho, iziguli ezinonembeza ecindezelekile, kukhona zibe futhi hypoglycaemia. Kufanele kuphawulwe ukuthi sibi crisis adrenal ngokuvamile eba ngemuva izimo ezifana ukuhlukumezeka okukhulu, ukuhlinzwa, ukutheleleka khona ukwehla elibukhali Isikali izidakamizwa.

side effects

Can nomthelela ongemuhle impilo reception nesineke "Fliksotid" izidakamizwa? Imiphumela engemihle cishe wonke amadivaysi ezokwelapha. Kanye nokunikeza imithi imuncwe iyathinteka.

• izivikeli mzimba: isikhumba ukusabela ngenxa hypersensitivity, angioedema (oropharynx nobuso), iziyaluyalu umgudu wokuphefumula (dyspnea noma bronchospasm), ukushaqeka anaphylactic.
• Futhi izifo yisinanakazana ezithathelwanayo: candidiasis emlonyeni nasemphinjeni, futhi thrush. Nge kwezinso elinjalo Kunconywa ukususa emphinjeni kanye umlomo ngamanzi plain. Ingase futhi ingasetshenziswa antifungals isinyathelo wendawo. Okuvame kakhulu side effects kulandela ukusetshenziswa aerosol kuyinto inyumoniya, kodwa iziguli ezine-COPD.
• Umzimba: Hyperglycemia.
• uhlelo endocrine: Cushing Syndrome, ukusebenza ukucindezeleka cortex adrenal, lenguquko ethize kunhlobonhlobo zamatshe encishisiwe ithambo izicubu, ukukhula retardation, ale nkinga, i-glaucoma.
• isimiso sezinzwa: izinkathazo, ezibangela ukuziphatha okuyinqaba, futhi ubuthongo, ukucasuka kanye hyperactivity (ikakhulukazi izingane).
• amafutha Ongama: nokulimala.
• uhlelo zokuphefumula: hoarseness (kunconyiwe ngokushesha ngemva kokuhlinzwa futhi ukuhahaza umlomo wakho ngamanzi), bronchospasm nakuba.

Kuxwayisa uma usebenzisa izidakamizwa

Evele khansela ukusetshenziswa kwezidakamizwa is hhayi Kunconywa.

Qaphela ikakhulukazi ekwelapheni corticosteroids imuncwe in iziguli ifomu abangasebenzi noma asebenzayo isifo sofuba.

Ukulandela ukuqokwa izidakamizwa udokotela kufanele uhlole ukuthi isiguli iyakwazi ukusebenzisa nesifutho. Ngesikhathi inqubo, kubalulekile ukuqinisekisa ukuthi wokwehla izidakamizwa e isenzo senzeka khona e ukuvumelanisa ngomoya. Kuphela ngale ndlela isiguli uzokwazi ukuqinisekisa ukulethwa kwemisebenzi yoMnyango timphawu asebenzayo emaphashini.

Kunconywa ukuba ngokuqhubekayo nokuqapha Dynamics ukukhula kwezingane ezincane abathola corticosteroids imuncwe isikhathi eside.

Lapho ngokudlulisela isiguli kusukela ekutholeni corticosteroids letindzala ukulapha ephefumula zingase zibe zimbi izifo nomzimba (isb, rhinitis iguliswa noma eczema) ukuthi wayeke ukuyiveza imithi letindzala. Ezimweni ezinjalo, ukwelashwa lingaze nge antihistamine noma imithi nezokusigcoba.

Njengoba imithi kakhulu imuncwe e aerosol iziqukathi, umphumela zokwelapha kungancipha uma ukupholisa spray.

Kuze kube manje, kukhona imibiko ezingavamile ukuthi isiguli, sisuke sicabanga usebenzisa ithuluzi, ukwenyuka kwamazinga igazi glucose. Lokhu kufanele ngaso sonke isikhathi zikhunjulwe odokotela lapho enquma izidakamizwa ukuze iziguli sikashukela.

Umthelela we ketshezi asebenzayo ikhono lomuntu ukuze usebenze umshini nokusebenza imishini ezidinga emakamu eliphezulu, ngeke kwenzeke.

Analogs nomuthi

Yini izidakamizwa lokuthenga, uma isiguli asikwazanga ukuthenga izidakamizwa "Fliksotid"? Analogs ithuluzi babe kakhulu ezifanayo kodwa ngesikhathi esifanayo. Kodwa ngaphambi kokuzisebenzisa batusa ukuthi ufunde imiyalelo ebiyelwe, kanye uthintane onguchwepheshe.

Okwamanje, Analogue elandelayo imithi: ". Valium" izidakamizwa "Kutiveyt", "Nazarel" "Flixonase" "Fluticasone" futhi Kufanele kuqashelwe ukuthi intengo lezi izidakamizwa kungenzeka ehlukile kunaleyo yasekuqaleni. By endleleni, le aerosol "Fliksotid" ungakwazi ukuthenga i-570 (50 .mu.g, 120 ngemithamo), 840 (125 mg, ngemithamo 60) noma 140 (250 .mu.g, ngemithamo 60) ruble Russian.

Uphenyo ezihogelwayo

What do kodokotela kanye neziguli mayelana 'Flixotide' zomuthi? Izibuyekezo salesi sibhedlela ngokuyinhloko omuhle. Lokhu kungenxa ngokuyinhloko iqiniso lokuthi nomuthi aerosolized has kahle kuqhathaniswa eliphezulu. It kwehlisa ukuvama ukuhlaselwa iziguli isifuba somoya, futhi kuthuthukisa patency bronchial e kulabo abaphethwe nesifo samaphaphu.

Ngokuqondene Izibuyekezo ezingezinhle, njengoba umthetho, zivela ezigulini esetshenziswa imithi ngendlela engafanele noma cha udokotela. Ngakho-ke, ukuze athole imiphumela emihle kakhulu ngaphambi kokusebenzisa izidakamizwa, kanye nozakwabo zayo, kutuswa ngempela ukukufunda ngokuningiliziwe imiyalelo okuvalelwe ukusetshenziswa. Ngaphezu kwalokho, kubalulekile ukuba aye kudokotela, ngubani, eqinisweni, futhi kumelwe ukuncoma leli thuluzi, ngokusekelwe imiphumela ngihlolwa.

Indlela ukugcina ekwakhiweni aerosol?

aerosol imuncwe Kunconywa ukubeka endaweni emnyama lapho izinga lokushisa ingeqi degrees 25. ingukuphila eshalofini zomuthi ncamashi iminyaka emibili. Emva kwalesi sikhathi-ke kungavunyelwe ukusebenzisa.