Fibrinogen - kuyinsakavukela pathology

Esifundweni kohlelo igazi ekunqandeni, lokhu Inkomba kunqunywa ngempela. Kubalulekile etimeni letehlukene. Ngaphambi kokuhlinzwa, belungiselela sokubelethisa, izifo zenhliziyo kanye sokuvuvukala igazi njalo ukunquma fibrinogen. Norma kwakungelona abadala kanye nezinsana okufanayo. Kwabesifazane abakhulelwe, mkhawulo we yayo kakhulu kunalokhu. Kodwa ukugxila amazinga ngemva kwesikhashana. Okokuqala, ake sixoxe ngalokho ngokuvamile limelela fibrinogen.

Ngokusho isakhiwo yabo zamakhemikhali, kuba - amaprotheni. Ibizwa nangokuthi ngaphezulu ekunqandeni izici I. ehilelekile esigabeni sokugcina igazi ekunqandeni, okungukuthi - kwetinhlavu ihlule legazi. Ku-fibrinogen yomuntu ephile esikhathini igazi elikhona isimo siphela.

Endabeni ukusebenza ohlelweni coagulation at isigaba saso sokuqala ngaphansi isenzo nezinye izakhi ezijiyisayo kwakhiwa thrombin.

Esigabeni sesibili ngaphansi kwethonya fibrinogen ekunqandeni kanye thrombin wajinge wanamatsela ibe fibrin zingaxazululeki, okuyinto yakha isisekelo ihlule legazi, a thrombus. Luhilela ephumula ukopha. Yingakho kuba incazelo ecacile ukuthi umzimba kufanele fibrinogen. Kuyinsakavukela yalesi izidakamizwa umuntu omdala onempilo oluhambisana 2-4 g / l. Ngo ezisanda kuzalwa, isilinganiso ingaphansi - 1,25-3 g / l. Kodwa liyophuma ngesikhathi sokukhulelwa ukuze 6 g / l. Lokhu kuyaqondakala. Phela, isidumbu sowesifazane silungiselela sokubelethisa, okuyinto njalo elihlobene ne ukopha. Ngakho, kuvela, ngesilinganiso fibrinogen egazini akuyona yonke efanayo. ke iphezulu kakhulu kubantu besifazane abakhulelwe.

"Yebo, kodwa livelephi kusuka?" - ubuza. It kuvela ukuthi lokhu yikona ekunqandeni ikhiqizwa sesibindi amaseli kohlelo reticuloendothelial. Ngakho-ke, ngo-izifo kwesibindi, ezifana sokusha kwesibindi noma isifo sokusha fibrinogen esindayo kabani kuyinsakavukela - hhayi ngaphansi kuka-2 g / l, ngezinye izikhathi sehliselwe izinombolo ezincane kakhulu. Lokhu kungaholela ezihlukahlukene ukopha, ukopha isikhumba kanye nolwelwesi lwamafinyila. Ukuthatha imithi ethile (androgens, ama steroid) futhi kungehlisa izinga layo. Kwezinye izimo, kukhona amaphutha esizalwa nawo wokuhle imfundo isici I. Lokhu kubizwa ngokuthi afibrinogenemia noma hypofibrinogenemia.

Ukwehla abukhali fibrinogen siyenzeka esigabeni sesibili nesesithathu dessiminirovannogo intravascular coagulation syndrome. Lesi simo esindayo sokugembula, ngokuvamile ziphethe ukopha ezinkulu ngenxa ukwakheka izitsha ezincane zihlakazeke fibrin amahlule. kuyinto yabo kangaka ukuthi fibrinogen bawuphundle amasheya. fibrinolysis olunamandla, inqubo ukuthi lihlotshaniswa nasekuqiniseni kuqedwa fibrin, futhi kuhambisane Ukwehla fibrinogen. It kunciphisa okungamahlala wegazi myeloid, ne nokuntuleka vitamin B12 emzimbeni futhi S.

Kwezinye izifo, kunalokho, kukhona i fibrinogen anda. Norm Inani elikhulu coagulating isici ilingana 4 g / l. Kodwa rheumatism, izifo ezithathelwanayo, izinqubo ukuvuvukala, umdlavuza, thrombosis futhi infarctions isici mina level kungaba kukhuphuke ngo izikhathi 1.5-2.5. Fibrinogen ubizwa nangokuthi acute isigaba amaprotheni, kusukela izithelo zawo kuhambisana acute isifo ukuvuvukala. Izinga le amaprotheni ilimele, ukusetshenziswa zokuvimbela inzalo temlomo na estrogen ngemva kokuhlinzwa.

Kunobufakazi bokuthi amazinga fibrinogen ephakeme kungase sibandulele ukubukeka yokufa uhlangothi nokumelwa yinhliziyo. ubuhlobo ocacile phakathi lezi zifo futhi ezingeni sangaphambilini isigqugquzeli itholwe ucwaningo.

Ukuze kutholakale izinga fibrinogen Uzodlula esiswini esingenalutho igazi emthanjeni. Igazi esithathwayo ibe tube test ne anticoagulant.