Yiziphi amaphilisi eqeda ukuvuvukala?

Ukuvuvukala - okungukuthi, ngokuvamile, ukusabela komzimba zemvelo ukuze umzamo ye Isingeniso eziphilayo ningabafokazi kulo. Ngakho, lesion kukhawulwe ejenti ezithathelwanayo futhi ubhujiswe. Kodwa umzimba akuyona njalo wakwazi kanjani ukubhekana nalesi sifo. Ukuze kuholele umonakalo ebalulekile ukuze kwezitho nezicubu zomzimba, ngisho nalapho kungenziwa i- imisebenzi yabo, ngokuvamile zisebenzisa izidakamizwa eqeda ukuvuvukala. Ngaphandle kwawo, ongakwenza nge ukuphumelela ukwelashwa etiotrop. Uma sikhuluma course njalo letindzala isifo ukuvuvukala sezicubu zezinzwa futhi kukhona ingozi ukukhubazeka esiguli, ukusetshenziswa kwezidakamizwa eqeda ukuvuvukala kusenesikhathi kumane kunesidingo.

Zonke amaphilisi eqeda ukuvuvukala zihlukaniswe ngezigaba ezintathu eziyinhloko: steroid, non-steroidal futhi isenzo kancane.

steroid

Lezi zihlanganisa corticosteroids. Ekuqaleni, lezi kwakungezona: cortisone futhi hydrocortisone ethathwe nadpochesnikov. Manje eziningi lezi zimali ungeze izidakamizwa zokwenziwa: prednisolone, methylprednisolone, nemikhiqizo fluorinated - dexamethasone, triamcinolone, flumethasone, betamethasone. Ama-steroid ngenkuthalo zivimbela phospholipase A2, futhi lokhu abonise imiphumela eqeda ukuvuvukala. I izinkomba ukusetshenziswa kwezidakamizwa kukhona zonke izinhlobo asebenzayo rheumatism. Ukwelashwa eside, kuze kufinyelele ezinyangeni 2, ngokuvamile kuhlangene izidakamizwa ezingekho steroidal.

Kusho isenzo kancane

Lezi amaphilisi eqeda ukuvuvukala zisetshenziselwa ukwelapha izilonda letindzala sezicubu zezinzwa, i-rheumatoid arthritis. Lokhu kwelashwa eziyisisekelo imithi umphumela kancane, esizibonakalisa kwezinyanga ezimbalwa. Lezi zihlanganisa igolide izimali hingamin (delagil, chloroquine), penicillinamine, cytostatics, nabanye.

izidakamizwa Nonsteroidal eqeda ukuvuvukala (ama-NSAID)

Leli qembu yilona ezivamile. Nonsteroidal eqeda ukuvuvukala amaphilisi futhi ifa isinyathelo antipyretic kanye analgesic. ukuthandwa Omkhulu sinikeze spectrum ezibanzi yesenzo kanye nekghono eliphezulu. Nsuku zonke, leli qembu izidakamizwa zithatha angaphezu kwezigidi ezingu-30 abantu emhlabeni wonke, lapho cishe ingxenye yabo phezu kweminyaka eyi-60. Abantu abaningi ukuthenga imithi emakhemisi ngaphandle kadokotela.

Ama-NSAID zihlukaniswe amaqembu esekelwe isakhiwo zamakhemikhali kwimodi yesenzo. Eyokuqala ihlanganisa ukusebenza kahle eliphezulu amaphilisi anqanda. Lokhu salicylates (kubandakanya wonke aspirin eyaziwa), pyrazolidine (Phenylbutazone), amagama ahlobene indoleacetic (indomethacin, sulindac) kanye phenylacetic (diclofenac) acid, oxicams (piroxicam nabanye.), Derivatives ka propionic acid (ketaprofen ibuprofen, naproxen, njll ) .. Leli qembu futhi zihlanganisa ezinye nemikhiqizo non-acid, isib, alkanones (namubeton), sulfonamide nemikhiqizo (nimesulide, rofecoxib).

Ukwakhiwa neqembu lesibili ube umsebenzi ababuthakathaka eqeda ukuvuvukala. Lezi, ngasendleleni, libhekisela paracetamol ethandwa.

Isenzo ama-NSAID kusekelwe okusithiyayo of cyclooxygenase (Cox) - i-enzyme ehilelekile prostaglandin zamagama. Laba modulators we ukuvuvukala inqubo, umkhiqizo ukubukeka ubuhlungu futhi kungazelelwe kuzuba e lokushisa (imfiva).

Ama-NSAID babe eminingi engemihle, kodwa eminyakeni yamuva yaqala ukubonakala isizukulwane esisha izidakamizwa (meloxicam, tenoxicam, nabumetone, solpafleks) ukuthi ngokukhetha zivimbela prostaglandins, ukunciphisa kakhulu amathuba wokuthuthukisa lezi yezinkinga edabukisayo. Azi inani elikhulu nemiphumela emibi, eyinqaba nemithi eminingi, izidakamizwa eqeda ukuvuvukala ngokuvamile akukhetha, uma kukhona ithuba lokukhetha.