Umuthi 'Atokor ": imfundo manual, Analogue and Izibuyekezo

High amazinga cholesterol plasma kunomthelela ukuthuthukiswa isifo sokuqina kwemithambo yegazi kanye nesifo senhliziyo inqubo.

Ukuthwala lipid ukwehlisa ukwelashwa usebenzisa izindlela ezikhethekile, enye yazo izidakamizwa "Atokor". Imiyalelo kule imithi eliyichaza yayo hypocholesterolemic futhi gipotriglitseridemicheskuyu ekwehliseni lokuhlushwa cholesterol eziyingozi namafutha emzimbeni womuntu.

izici Jikelele

Umuthi libhekisela inhibitor ka reductase 3-methylglutaryl-3-hydroxy-CoA. "Laboratories Dr. Reddy sika" kuveza inkampani Indian.

Lapho belungela ukuya khona "Atokor" Isikali kungenzeka 0,020 futhi 0,010 g

ukukhululwa Ifomu

ejenti akhiqizwa ifomu tablet camera nge ifilimu emhlophe. Tablets extruded simise calantsatfu evele biconvex kwenye lapho incwadi "A" sisetshenziswa, futhi enye eyabizwa ngokuthi umthamo "10" noma "20".

isakhiwo

Isithako asebenzayo we umuthi atorvastatin, okumelelwe micronized calcium trihydrate. Kwezokwelapha "Atokor" Isikali kanye nokwakheka ambalwa isithako ukuhluka. Njalo 0,01084 noma 0,02168 g atorvastatin calcium trihydrate okulingana 0.01 noma 0.02 g atorvastatin okumsulwa.

Ubisi ushukela, i-calcium carbonate, sodium croscarmellose, polysorbate 80, hydroxypropyl cellulose, lactose DT, magnesium stearate isakhiwo ithebhulethi kwakhiwa.

I bezinhlamvu ifilimu kwakhiwa kusukela hypromellose 15 CPS, propylene glycol, talc sebehlanjululwe titanium dioxide.

Kungokufanayo kokubili umthamo kusho "Atokor" Ukwakheka, futhi abaqondise Imininingwane yabo.

Izibhebhe 0.01 noma 0.02 g izingcezu 10 ekhiqizwa endaweni ibhamuza zahlanganiswa ebhokisini amakhadibhodi.

mshini wezenzo

Imithi afundiswe isicelo siphathelene abakhethayo, retarders yokuncintisana 3-methylglutaryl-3-hydroxy-kofermentaA reductase. Kuyinto i-enzyme kubalulekile ukuguqulwa kwakwakhe 3-hydroxy-3-metilglyutarilkoenzima A kuya mevalonic acid obulandela styrenes cholesterol.

Uma iziguli hypercholesterolemia, uhlobo homozygous heterozygous ngofuzo futhi okungezona ngofuzo, futhi dyslipidemia okuxubile, edonsa izidakamizwa "Atokor" kusiza ekwehliseni cholesterol Imininingwane, cholesterol izinhlayiya ku lipoproteins density ongaphakeme ophansi kakhulu, triglyceride futhi apolipoprotein B.

Nomuthi "Atokor" incazelo izidakamizwa kubonisa ukuthi kungaba amaphilisi engazinzile ewusizo ukwandisa ezingeni sterol e lipoproteins nge high density.

Ngo amaseli isibindi, kanye nama-molecule triglyceride holesterolovye esiyingxenye ebalulekile zezinto Esilula kokuba inhlanganiso eqinile ongaphakeme. Basuke ithunyelwa plasma, okuyinto ukungena izicubu neuropathy. Kulezi compounds kwakhiwa Esilula nge ukugcwaliswa ongaphakeme bakwazi ukuphendula catalyzed nge ziyezwana okusezingeni eliphezulu yokwamukela uhlobo zokwakheka. Konke lokhu izinto kungaba ngcono ukuthuthukiswa isifo atherosclerotic.

Isenzo Atorvastatin elinesimo ukwanda ngokuphawulekayo futhi ephikelela nekusebenta izakhiwo LDL-yokwamukela, ekunciphiseni eziyingozi cholesterol lokuhlala at hypercholesterolemia oluphakeme homozygous uhlobo sitholwa njengefa.

Kusho "Atokor" imfundo kubonisa ikhono layo ukuze wehlise plasma amazinga cholesterol kanye Esilula ngu ezivimbela HMG-CoA reductase enzyme. It kubambezela kumiswa cholesterol amaseli isibindi, kwandisa isibalo zokwakheka yokwamukela ye lipoproteins nge ukugcwaliswa ongaphakeme e ulwelwesi cell. Lokhu kuthuthukisa ukuthunjwa futhi catabolism cholesterol kusukela molecule Esilula emakamu low.

Yini isetshenziswa

Nomuthi "Atokor" Umsebenzisi Isicelo weluleka amaphilisi kuzimpawu eyinhloko anda cholesterolemia uhlobo heterozygous, zendawo okungewona wendawo okwandisa cholesterol okuhlushwa, geterlipidemii okuxubile, esengeziwe plasma triglyceride molecule.

Basuke iqondiswa lihambisana imfundo wezokudla ukwehlisa okusezingeni eliphezulu cholesterol ku lipoproteins nge ukugcwaliswa ongaphakeme, apolipoprotein B kanye triglyceride compounds.

Tablets ukunciphisa okuhlushwa plasma cholesterol LDL cholesterolemia at aphakeme homozygous uhlobo emkhayeni, lapho ukudla wezokudla futhi ezinye izindlela ze-non-kwemithi ayizwakali.

Indlela

Nomuthi "Atokor" yokusetshenziswa incoma ukuphuza kuphela ngemva kokubekwa esikhundleni Ukudla hypocholesterolemic umuntu ejwayelekile ogulayo, okumele kusetshenziswe ngezikhathi yokwelapha. Umthamo isethwe ngokuhlukile esigulini ngasinye, okuyinto ibalwa ezingeni kokuqala cholesterol lipoproteins nge ukugcwaliswa ongaphakeme. Kubalulekile ukuba acabangele ukusetshenziswa ehlosiwe, ukuphumelela ukwelashwa nge "ubufakazi Atokor '.

Ngokuvamile, umthamo kokuqala okulingana 0.010 g ngesikhathi esisodwa ngosuku. Ukusetshenziswa amaphilisi akuxhomekile isikhathi sosuku nokudla ukusetshenziswa.

Umthamo izindlela yansuku zonke 0,010 ukuze 0,080 g kuyakhethwa kusukela kokuqala ezimali izinkomba cholesterol eziyingozi, ilitshe izakhiwo kanye ukusebenza siqu. Esigabeni sokuqala isicelo kanye nekwandzisa lokuhlushwa izidakamizwa kufanele kube nengxenye inyanga hlola izinga le-plasma amafutha, futhi ulungise umthamo njengoba kudingekile.

hypercholesterolemia Primary futhi kuhlanganiswe hyperlipidemia uhlamvu iphathwa umthamo nsuku zonke 0,010 g

umsebenzi zokwelapha kwenzeka ezinsukwini ezingu-14, kanye nekusebenta esiphezulu kungenzeka emva kwenyanga eyodwa. ukusetshenziswa isikhathi eside kwenza ukuthi singakwazi ukugcina nomphumela oqabulayo.

Imithi "Atokor" e inhlukano Russian iqukethe ulwazi terapiigiperholesterinemii ka homozygous uhlobo kwamalungu omkhaya. Ngokuvamile, ebekiwe umthamo nsuku zonke 0.080 g Kulesi sokusebenzisa ukwehla LDL cholesterol amagugu-40%.

Izici yokwelashwa

Izibhebhe "imiyalelo Atokor 'ukusetshenziswa sinconywa ngaphambi kokuqala ukusebenzisa izidakamizwa kumele uthole imbangela ukukhuphuka yesibili cholesterol amagugu. Lezi zinto zibandakanya sikashukela, impatho abampofu sikashukela, i-hypothyroidism, nephrotic inqubo disproteinemicheskih izinguquko, obstructive isifo sesibindi. Lokhu kungabandakanya ukwelashwa nezinye izidakamizwa futhi ekubeni imilutha yotshwala. Kwaze kwaba yilapho sebeshiye ukususa izizathu ngenhla, usukulungele ukusebenzisa ithebhulethi "Atokor".

Ngisho nangaphambi kokuba ukwelashwa wenziwa ukuzimisela lipid ibhalansi phakathi cholesterol Imininingwane, LDL cholesterol e HDL cholesterol ne-triglyceride.

Azikho idatha ukusetshenziswa kwemithi labantu ezingane, ngakho lezi amaphilisi aluboniswa izingane.

Ekwelapheni ezigulini esezikhulile, ogama yobudala engaphezu kwengu-60, kuyinto kwamazinga plasma esebenzayo ejenti ingxenye ku-40%.

Endabeni ka ukwephulwa of ukusebenza kwezinso Akubalulekile ulungise umthamo, njengoba lokhu isimo akuphazamisi okuqukethwe atorvastatinovoe esegazini kanye nokusebenza ukwehlisa cholesterol embi.

Kunobufakazi bokuthi ukusetshenziswa kwalesi isigaba izidakamizwa kubangele myopathy ukuthuthukiswa rabdomioliznoy futhi enganele izinso umsebenzi ngendlela oyingozi. Kulezi izifo yimithi kumelwe zilahlwe ngaleso sikhathi.

Amalungiselelo ngesisekelo atorvastatin okufanele zithathwe ngokucophelela abantu ababusebenzisa kabi utshwala noma ukuba kwadingeka isifo sesibindi esikhathini esidlule.

Isenzo inhibitor ka HMG-CoA reductase enzyme kungenzeka izinguquko izinkomba kwamakhemikhali umsebenzi sesibindi. Ukuze ukufakwa ngesikhathi esifanele komgomo ezinjalo kudingeke aqhube nokuhlola umsebenzi hepatic, bese 3 izinyanga emva ngokuthatha amaphilisi afeze isheke ngaphambi kokwelashwa.

Izidakamizwa "Atokor" sicondziso Russian kuhlanganisa ulwazi mayelana nokwenyuka olukhulu endleleni plasma amagugu isithako esebenzayo in iziguli isifo sesibindi, abaphethwe etshwaleni. ukuhluleka yokwelapha lesikhashana noma ephelele ibuyisela isibindi transaminase umsebenzi in the ifremu yasekuqaleni. Iziguli eziningi akasiqedanga ukusetshenziswa kwezidakamizwa ngemithamo emincane, futhi akukho ukusabela ezingezinhle wazithatha.

Ekwelapheni bangase babe nomuzwa isiyezi, ukuthuthukisa ukozela, ngakho ngesikhathi isicelo amaphilisi iziguli banqatshelwe ukulawula ezokuthutha kanye namanye amathuluzi eziyinkimbinkimbi.

Ubani akufanele usebenzise

On nomuthi "Atokor" Izimo zihlanganisa ezwela kwabaningi isithako we nomuthi ngamunye.

Akazange athathe esimweni acute isibindi isifo futhi kusebenze eliphezulu transaminase serum enzyme lapho inkonzo yabo izikhathi 3 ephakeme kunaleyo mkhawulo yamanani evamile.

Umuthi akukashicilelwa ukuba nabesifazane asebeneminyaka efanele yobudala zokuzala abangabhalisile lokuvimbela inzalo ezanele. Contraindication kuwumbandela walesi abantwana ibele.

Medicine alibheki izingane nentsha engaphansi kwengu-18 ubudala.

Ngenxa yokuba khona ubisi lichaza ekwakheni Atokor "imfundo izibhebhe 'ushukela ku isicelo sivimbela ukusetshenziswa kwabo ngendlela ukungabekezelelani ifa galactose amangqamuzana, ngenxa yokuntula lactase nezinhlayiyana zikashukela-galactose malabsortsii.

analogs

Kukhona inani elikhulu izidakamizwa ngesisekelo atorvastatin. Cholesterol-ukwehlisa indima zemithi "Atokor" imfundo manual. Analogs bayakwazi wehlise izinga cholesterol embi egazini.

Omunye imithi enjalo ikhambi isiSlovenia "Atoris", okuyinto nomkhiqizi inkampani ngokuhlanganyela stock "Krka, Novo Mesto." It ikhiqizwa ngesimo amaphilisi nge okuqukethwe okusebenzayo isithako 0.010 g, 0.020 g, 0.040 g

Umuthi senzelwe ukuqeda isimo hyperlipidemic, lapho nemingcele labanti ladzingekako kute kuncishiswe cholesterol Imininingwane, Esilula cholesterol compounds nge ukugcwaliswa ongaphakeme, inani apolipoprotein futhi ama-molecule triglyceride ekusakazeni igazi.

Izidakamizwa uswidi abantu hypercholesterolemia polygenic heterozygous homozygous uhlobo kwamalungu omkhaya.

Ngosizo "Atoris" izidakamizwa kwandisa lokuhlushwa cholesterol lipoproteins nge ukugcwaliswa okusezingeni eliphezulu.

Enye Analogue Slovene kubhekwe izidakamizwa "Tulip," okwenziwa manje "Lek Inkampani ekhiqiza imithi". Kukhona imithamo emithathu amaphilisi ifilimu-camera: 0.01 g, 0.02 g futhi 0.04 g

Umuthi kuboniswa zokuqeda amafomu eyinhloko hypercholesterolemic futhi kuhlanganiswe isimo hyperlipidemic, ukuze kwelashwe cholesterol isigqugquzeli uyakwazisa heterozygous futhi homozygous uhlobo umndeni.

Ngokufanayo, indlela kubhekwe imithi Indian "Astin", okuyinto kuveza ibhizinisi "Micro Labs Limited". Itholakala imithamo ezimbili: at 0,010 g futhi 0,020 g atorvastatin.

Umuthi ezinqunyiwe i-lipid okuqukethwe lenyuke, uma ningagcini umphumela omuhle izenzakalo wezokudla nezinye.

Indian yokukhiqiza i nomuthi "Storvas" esekelwe usawoti calcium ka atorvastatin. Oluqanjwe "Ranbaxy Laboratories Limited" ngesimo esibhebheni camera nge emgodleni e imithamo ezimbili: at 0,010 g futhi 0,020 g

Izidakamizwa "Storvas" ukunciphisa okuqukethwe okusezingeni eliphezulu cholesterol Imininingwane, LDL cholesterol molecule e, futhi lokuhlushwa apolipoprotein triglyceride compounds kule primary, futhi nonmarried heterozygous ngofuzo isimo hypercholesterolemic, kanye okuxubile isifo hyperlipidemic.

Imithi kunciphisa kungenzeka isilethikusebenza esivimba amanzi isimo emangalisa kwemisipha, unhlangothi futhi izinguquko cerebral ukugeleza kwegazi. Tablets kancane phambili isimo senhliziyo atherosclerotic.

uzakwabo American Isidakamizwa "Lipitor" kuveza "Pfizer". It ikhiqizwa ngesimo amaphilisi camera nge igobolondo imithamo emithathu: at 0.010 g, 0.020 g, 0.040 g Umuthi liyasetshenziswa ukuqeda uthi hypercholesterolemic ezahlukene imvelaphi.

Izibuyekezo

Medicine "Atokor" Umsebenzisi Isicelo uchaza njengoba kusho nge high kusebenta efakazelwe. Iningi leziguli ezine-isigqugquzeli plasma lokuhlala cholesterol eziyingozi, ngemuva Yiqiniso yokusetshenziswa iba ngcono. Amanani cholesterol inani LDL cholesterol ziyancipha ezingeni evamile, okuyinto kunciphisa amathuba asathuthuka atherosclerosis, nemibandela ischemic.

Umuthi kungokwalabo abezindaba ne tolerability ezinhle, kodwa ezinye iziguli kungase kubangele sezinyawo ukubambezeleka, ukuvuvukala, ubuhlungu esiswini, isicanucanu, ukuqunjelwa. Kukhona ikhanda, ubuthongo siyabhubha. Kwangathi ukuthuthukisa nomqwayiba, asthenic futhi isimo myalgic.

Ezimweni ezingavamile, side effects kukhona myositis kubonakala, myopathy, paresthesia, peripheral neuropathy, pancreatitis, isifo sokusha kwesibindi, jaundice cholestatic.

Tablets kungabangela sokuzincisha ukudla, ukuhlanza, hepatotoxicity ukubonakaliswa, Alopecia, ukubonakaliswa pruritic ka ukuqubuka, ubuthakathaka, ale nkinga, hyper- noma kahle kungakhuphula izinga likashukela.