Streptomycin izilwane: yokusetshenziswa, incazelo kanye nokubuyekeza

Ziyini izindleko nalokho kuboniswa umuthi wezilwane ngokuthi "i-streptomycin"? Yokusetshenziswa, intengo, kanye nokuqokwa zomuthi kuzoxoxwa ngezansi.

incazelo Ifomu izakhiwo wezilwane

Ukulungiselela "streptomycin sulfate" (wezilwane) kuyinto organic base usawoti okuyinto kuveza ekhazimulayo ukhunta encanyana.

Ukudayiswa loku kusho ukuthini ihlinzekwa njengoba powder hygroscopic noma okusindayo ukungena nakwamanye amazwe umbala omhlophe, ukunambitheka ababayo, ngaphandle iphunga futhi encibilikayo kalula emanzini, novocaine kanye nosawoti.

"Streptomycin" ngoba wezilwane ngokuvamile ngakho wasebenzisa njengoba kudingeka. Kufanele kuqashelwe ukuthi esitebeleni konemimoya wavuma azibukhali, kodwa ephukile kahle izixazululo ane-alikhali (nge Ukushisa) futhi acid eqinile.

yezemithi nomuthi

Kanjani lesi sidakamizwa "streptomycin" izilwane? Yokusetshenziswa ibika ukuthi lokhu ejenti has amagciwane kanye izakhiwo bacteriostatic ngokumelene igremu-negative futhi igremu-HIV amagciwane amaningi abangela izifo.

ukusebenza Elwa Namagciwane zomuthi kunqunywa ngekhono laso lokucaca ekuvimbeleni amaprotheni zamagama kumaseli microbial e ezingeni ribosome. Kuyaqapheleka futhi ukuthi izidakamizwa akunamthelela ngegciwane kubangelwa Clostridia nezinye anaerobic amagciwane, isikhunta, plasmodia, amagciwane kanye rickettsia. Ngaphezu kwalokho, angenziwa ezithile has ukumelana enhle kakhulu i-streptomycin, namagciwane proliferating e ukumelana lo muthi kwenzeka ezinsukwini ezimbalwa. Iningi olumelana nemithi ukuthuthukisa ekupheleni lwenyanga yesibili yokwelashwa. Ukuvimbela lokhu mkhuba futhi ukuqeda lesi sifo, kufanele usebenzise imithamo emikhulu zomuthi, kanye ukuhlanganisa nabanye ejenti elwa namagciwane.

Izimfanelo pharmacokinetic zomuthi

ngabe izidakamizwa amuncwa umzimba, "streptomycin" izilwane? Iziyalezo yokusetshenziswa lithi uma busuka it is hhayi ugxile futhi iqedwe ngokuphelele ngokusebenzisa wamathumbu.

Ukuze imijovo esicutshini isithako esebenzayo zomuthi amuncwa umzimba ngokushesha egazini, futhi liyatholakala nasemiBhalweni izimbotshana pleural futhi peritoneal, Bile, amahlaya Vitreous, umchamo, namehlo.

Ngo ukuvuvukala acute kule ingaphakathi pleural we lokuhlushwa ejenti-antibiotic ongafinyelela mayelana 50% ezingeni egazini.

Ekuthuthukiseni meningitis streptomycin bakwazi ukungena emgudwini umgogodla e isamba 10-50%.

I-ejenti kuncike izophela kalula ngokusebenzisa placenta. Ngo operation evamile, isibindi streptomycin aqoqana lokuhlala abaphakeme esikhathini tubules hepatic. Lapho siyabhubha umsebenzi walo mzimba ke engena Bile izinto eziningi ezincane, kanye cholecystitis nokuqukethwe kwalo esinyeni nenyongo imayelana 85% ezingeni egazini.

Zokwelapha i-streptomycin lokuhlushwa ezicutshini ehlukahlukene izitho igcinwe amahora 8-13. Lokhu kwaziswa excreted ku umchamo pretty masinyane.

Izinkomba ngoba izidakamizwa

Yikuphi ephatha yezifo izimali? Yini lokhu kusho yokusetshenziswa zomuthi? "Streptomycin sulfate" uqoke:

• nge leptospirosis, tularemia, i-pneumonia,
• edema isifo wezingulube futhi Erysipelas, catarrhal imfiva (abulalayo);
• izifo diplokokkovyh, mastitis, endometritis;
• endocarditis, meningitis, sepsis puerperal nesilonda;
• actinomycosis izinkomo nokuhlaba campylobacteriosis, kanye nezinye izifo, ama-ejenti okuyinto iyashesha ukuzwela uma streptomycin ukuphi.

Uvala ukusetshenziswa

Uma akufanele ezinqunyiwe isidakamizwa "streptomycin" izilwane? Iziyalezo yokusetshenziswa bephethe imithi, ithi Izimo ezilandelayo:

• okusezingeni eliphezulu isilwane luvelo aminoglycoside imithi elwa namagciwane;
• khona izifo zenhliziyo nemithambo yegazi kanye kwezinso.

Kufanele kuqashelwe ukuthi le izidakamizwa ayikwazi kuhlangene nezinye izidakamizwa aminoglycoside (kuhlanganise "neomycin" kanamycin "," monomitsin, "Gentamycin") ngenxa kungenzeka ukwanda umphumela nephrotoxic.

Umhlahlandlela ukulungiswa "streptomycin sulfate" (ku isicelo izilwane)

Ngaphambi ukusetshenziswa, kwathiwa ziyoncibilika kubhekwe izindlela nosawoti, amanzi oyinyumba, noma 0.25-0.5% isixazululo m novocaine. Ngakho zithobele ubuhlobo ezilandelayo: 0.25 g streptomycin no 1 ml kuphela. By the way, isixazululo glucose njengoba ukusetshenziswa zokugcina akuvunyelwe.

Okuningi izimali kanzulu kungase kube buhlungu kakhulu. Isixazululo eqeda kungenziwa ligcinwe ngaso ekamelweni lokushisa ngeviki (mhlawumbe zimumethe ikamelo ukupholisa).

kufanele ngisebenzisa kanjani izidakamizwa "streptomycin" izilwane? Yokusetshenziswa uthi isixazululo esiphelele ingasatshenziswa intramuscularly futhi ihlelwe ngokulandelana kwezihloko, ngokwezihloko, ngomlomo, vnutrivymyanno, intraperitoneal, intratracheal, intrauterine, futhi intracisternally.

Esicutshini imijovo izilwane shí imisipha. Ukwelapha okunjalo Kwenziwa izinsuku 4-7. I nomuthi iqondiswa kabili ngelanga ngesikhathi esingaba ngamahora angu-12 alandelayo imithamo:

• Izinkomo esihle - 10 mg / kg izilwane omdala no-20 mg / kg izilwane ezisencane;
• amahhashi - 5 mg / kg izilwane omdala no-10 mg / kg izilwane ezisencane;
• Izinkomo ezinkulu - 5 mg / kg izilwane omdala no-10 mg / kg izilwane ezisencane;
• izinja, izingulube - 10 mg / kg izilwane omdala no-20 mg / kg izilwane ezisencane;
• izikhukhukazi - 30 mg / kg izilwane omdala no-40 mg / kg kwentsha.

Ngo leptospirosis izidakamizwa "streptomycin" iqondiswa izinsuku 4-10 ngezilinganiso 25 mg / kg. Ezimweni ezimbi kakhulu, kule nombolo kwandisa.

Kufanele kuqashelwe ukuthi le imithi kuhlangene 'polymyxin B "," penicillin "futhi sulfanilamidnymi kusho uma kunesidingo. Le nhlanganisela izidakamizwa is a action synergistic, kanye kuvimbela ukuqubuka kwamagciwane amelana streptomycin.

side effects

Manje uyazi ukuthi yini izidakamizwa kunesidingo "streptomycin sulfate." Iziyalezo ukusetshenziswa wezilwane njengoba kuchaziwe ngenhla.

Ukuze imijovo esicutshini e izinkomo kungenziwa wabonakaliswa yokungezwani komzimba ithuthuka ngokushesha, okuyinto ingozi empilweni futhi ngokuphila kwesilwane. Livela yezinkinga ezifana ezihambisana izici zomzimba wayo futhi akuxhomekile umthamo we-antibiotic esetshenziswa.

Futhi, yezinkinga ezihlukahlukene, zingaba khona ngemva ekuphathweni lokuqala izidakamizwa, ngokuvamile kubangelwa niqaphelisa isilwane nge okuphindaphindiwe course of ukwelashwa.

Ekwelapheni nale izidakamizwa e nemfuyo kungenziwa bephawula ukusabela anobuthi, uhudo, tachycardia, dermatitis, izithulu futhi kahle ngefanelo nangokuvumelana.

Izindleko kanye nokubuyekeza

Izindlela izindleko ukucabangela (isitsha 1 g) esesikhundleni ngoba ruble mayelana 18.

Abanye ochwepheshe musa batusa ukuba uhlanganise "streptomycin sulfate" futhi "penicillin" ku isipetu efanayo. Nokho, ezinye vets ngempela asebenzisa ngayo ngokuphumelelayo le nhlanganisela ekwelapheni imfuyo.

Abantu isikhathi eside nabo izidakamizwa wezilwane, baphikisa ngokuthi ukuxhumana okunjalo kuvame ukubangela kubo dermatitis ukuthuthukiswa.

Ngokwe Ochwepheshe bathi, ukubulawa kwezilwane, okuyinto "streptomycin" lwaqala, avunyelwe ukubamba eyodwa kuphela ngesonto emva ekuphathweni lokugcina izidakamizwa. Inyama yezilwane lihlatshwe phambi okuzifanele, kumele kusetshenziswe ukwenziwa ufulawa.

Njengoba for ubisi, ingasetshenziswa izinjongo ukudla kwayo kuze ngemuva kwezinsuku ezimbili zokugcina izidakamizwa abaphathi.