"Nimesulide" amaphilisi-mbumbulu. Yokusetshenziswa, nozakwabo yangempela

Pain - uhlobo umzamo zomzimba ukuze zidonse ukunaka lomuntu, ucele usizo. Ngakho akulungile ukuthi kukhona "embusweni Danish", kanye nomnotho umzimba akwanele ukulungisa inkinga, sidinga ukusekelwa kusukela ngaphandle.

Umthengi ezithaka imithi emakethe ye-Russian Federation ethulwa amakhulu izidakamizwa ukusiza abantu babhekane nobuhlungu. Zonke nemithi yenziwe ngohlobo oluhlukile, ububanzi futhi indlela ithonya. Omunye ephumelela kunazo kukhona izidakamizwa kusukela iqembu non-steroidal izidakamizwa eqeda ukuvuvukala. Phakathi kwazo kunane-ukumiswa kanye amaphilisi "Nimesulide".

Sakhiwo Ukwakheka

amaphilisi Round abe ukuma we-lenticular wangakwesokunxele. Ngo umbala kungenzeka ugodo ephuzi noma umane ophuzi. The main ingxenye esebenzayo - into Nimesulide kuthebulethi ngamunye - 100 mg. Kusukela inombolo kungenziwa ngokuthi ezengeziwe microcrystalline cellulose, isitashi (umbila), i-sodium isitashi glycolate, colloidal Silicon dioxide.

Ngaphezu kwalokho, isidakamizwa ezinikezwa amakhasimende ngesimo izimpushana for ukumiswa "Nimesulide." Ukwakheka kuyafana ukuthi amaphilisi, ngamunye 100 sachet mg main ingxenye esebenzayo.

pharmacodynamics

Nimesulide ngokukhetha kuvimbela cyclooxygenase-2, cyclooxygenase-1, umphumela wayo ngezinga elincane kakhulu. Kule ndaba, lo okusithiyayo of prostaglandins zamagama waphawula sokucasuka ukusabela ukuvuvukala. Nokho, kumiswa prostaglandin-uhlobo nimesulide zokulawula uzabalaza umphumela ngokulambisa lizwakale, okuholela sakugcina eseduze kuwukubonakaliswa isimiso sokugaya ukudla bungene.

Ngaphezu kwalokho, isenzo ephumelelayo nimesulide ebonakaliswa okusithiyayo kwetinhlavu radicals khulula. Nokho, izinqubo hemostasis futhi phagocytosis akusho babhekane nemiphumela yalolu ketshezi. Lo mshini nomuthi umphumela anti-inflammatory wayenethonya oluthatha indawo eside nekhono layo ukucindezela ukukhululwa kwe myeloperoxidase (e izifo eziningi ukuvuvukala kungabangela umonakalo izicubu, kuba omunye inembe kunazo izici zokuxilonga eyabonisa ingozi engase ilethwe isifo senhliziyo noma unhlangothi).

Izinkomba ukusetshenziswa

Wide ububanzi ngokwanele zomuthi "Nimesulide". On yini eyenza lokhu izidakamizwa? Ngoba izidakamizwa ine phezu umphumela womuntu eziyinkimbinkimbi - antioxidant, analgesic, antipyretic futhi anti - ke kunikezelwe ngenombolo izifo ukuvuvukala. izidakamizwa Ngempumelelo naphambi osteoarthritis (isifo ngokuhlanganyela kwasekuqaleni libhujiswa uqwanga articular), tendinitis (ukuvuvukala umsipha izicubu ukonakala), bursitis (ukuvuvukala izikhwama lwamafinyila, owandile emalungeni).

Imiphumela emihle ibonisa "nimesulide" ekwelapheni rheumatoid arthritis, izifo extra-articular rheumatism. elwa ngempumelelo ekulweni nezifo ezithathelwanayo ukuthi ahambisana izinqubo ukuvuvukala. Kaningi, "Nimesulide" ithebhulethi elisetshenziswa zabesifazane, ekwelapheni ukulimala Lokudabuka ezahlukene. Iziguli ngithi ukuqedwa ephumelelayo ubuhlungu ngesikhathi nokuvuselelwa nasezinkingeni ezilandela ngemva kokuhlinzwa.

Izimo "nimesulide"

Kusukela nomuthi libhekisela eqenjini National yesimanje Umhlangano Square, it has ngempela uhla lwezindawo Izimo. "Nimesulide" (kulokho kusiza imithi - obekuxoxwa ngakho ngaphambili) akumele sithathe abantu hypersensitivity kunoma ingxenye ngezithako zawo. Ayikho izidakamizwa zaphathwa kulezo ziguli elinomlando avele ukusabela hepatotoxic futhi hypersensitivity ukusabela njengoba rhinitis, bronchospasm, urticaria (ungabuqeda nge aspirin noma nabanye abameleli ama-NSAID leqembu).

Izimo ukusetshenziswa nomuthi iwukuba uneminye izilonda erosive-ulcerous wokugaya ukudla, ukuthambekela ukuthuthukisa ukopha yanoma yimuphi umsuka (t. E. Ukuhluka ekusebenzeni igazi ekunqandeni).

Medicine "Nimesulide" imfundo unqabela iziguli ezine kwezinso, hepatic, esingamahlalakhona senhliziyo ebuthaka. Iziguli "aspirin" somoya, utshwala sezidakamizwa futhi ungathathi izidakamizwa.

Musa akunikeze imithi kulezo zimo, uma isiguli luyanda lokushisa komzimba noma ezinye izimpawu zomkhuhlane kuyagcinwa. Ngaphezu kwalokho, akuvumelekile ukuthatha "Nimesulide" izingane, wakhulelwa futhi abesifazane lactating.

Okungenzeka ohlangothini ukusabela "nimesulide"

Isicelo se-nomuthi kungabangela eziningi side effects kusukela izitho ezihlukahlukene futhi izinhlelo zomzimba womuntu.

Ukusabela evamile esalotshwa wokugaya ukudla, futhi kuboniswa isicanucanu, ukuhlanza, uhudo, ukubuyisa, kanye nokuthuthukiswa kolwelwesi. Ngaphansi ngokuvamile zenzeka ukopha emathunjini, izilonda kuze perforation. Ngezikhathi ezithile ungezwa mayelana dyspepsia, stomatitis, ubuhlungu besisu.

Kungabangela "nimesulide" ohlangothini isinyathelo uhlelo hepatobiliary, avame ebonakaliswa kukhuphuke namazinga isibindi enzyme, okungenani - ekuthuthukiseni kwesibindi (kuhlanganise fulminant ..), Cholestatic jaundice.

On ukusabela esimiso senhliziyo nemithambo yegazi ongathi, uma kukhona lenyukile blood pressure, iziguli akuvamile exinwe palpitations inhliziyo, ukopha, siwasebenzise, umfutho wegazi ukweqa.

uhlelo urinary angaphendula ukubukeka edema (akuvamile), kuyaqabukela - urinary nokugcinwa, hematuria, dysuria. Kakhulu akuvamile kungase ukuthuthukisa ukwehluleka kwezinso, nephritis interstitial, oliguria.

ukusabela okungenzeka CNS uvame owabonakaliswa isiyezi, ukucobeka asthenia. Ngaphansi ngokuvamile kungenziwa wezwa ubuhlungu bekhanda, ukuthuthukiswa somnolence (ukufana okuyiluthayo ubuthongo), Reye Syndrome (encephalopathy), hypothermia (umzimba lokushisa ukwehla ngezansi ezingeni edingekayo ukuze silondoloze umzimba evamile). Ngezikhathi ezithile ungezwa mayelana ukusabela okunjalo "Nimesulide", njengoba uvalo, ukukhathazeka, amaphupho amabi.

Ngokuphathelene uhlelo lymph kanye uhlelo hematopoietic, "Nimesulide" (Umyalelo, abezimo eziphuthumayo Izibuyekezo uqinisekise lolu lwazi) Kungenzeka akuvamile avuse kwegazi, eosinophilia, kodwa mancane amathuba okuthi ukuthuthukisa thrombocytopenia purpura pantsitopenicheskaya.

Akuvamile, kodwa ungakwazi ukuzwa ngalolu thuthuva umzimba (hyperkalemia), isimiso somzimba sokuzivikela (hypersensitivity, anaphylaxis), izinhlaka umbono (umbono anyakaza, ingaphazamisi amasimu), zokuphefumula, mediastinum (ukuhlaselwa dyspnea, bronchospasm, isifuba somoya). Kwaba nokusabela kwesikhumba nezicubu ongama (ukujuluka, ukulunywa, dermatitis, urticaria, erythema, kakhulu akuvamile - anobuthi epidermal necrolysis, Stevens-Johnson syndrome).

Umthamo futhi isicelo wesifunda Imodi

Adult iziguli amaphilisi "nimesulide" belulekwa ukuba baphuze eyodwa ngesikhathi (100 mg) kabili ngelanga. Kungcono ukwenza kanjalo ngemva kokudla phuza amanzi amaningi lokuthi uzophulukiswa. Uma kuba powder for ukumiswa ke okuqukethwe eyodwa sachet buhlanjululwe ngo 100 ml amanzi. Izingane Ezisathomba engaphezu kwengu-12 ubudala asikho isidingo ukushintsha umthamo, futhi izingane lokhu izidakamizwa ukuze angamukeli akuvumelekile. Endabeni ekwelapheni iziguli esezikhulile ukulungiswa umthamo hhayi lwenziwa.

Kubantu abaphethwe esingamahlalakhona hepatic, creatine imvume ku ezahlukene 30-80 ml / imiz., I Isikali ayilungile. Uma le nkomba kwehlisa (30 ml / iminithi noma ngaphansi.) - sinqatshiwe ukuthola nomuthi.

Lawa izincomo main yokwamukela lesi sidakamizwa "Nimesulide". Umthamo ikhethwa kancane ngempumelelo, futhi emfushane isikhathi kungenzeka, okuzokwenza unciphise ingozi nemiphumela emibi. Yiqiniso Maximum yokwelapha nokusetshenziswa "Nimesulide" ngeke sidlule izinsuku ezingu-15.

Isikali ngokweqile: Izimpawu, Ukwelashwa

Ukuthatha iphilisi "Nimesulide", kubalulekile ukuba banamathele ngemithamo Kunconywa imiyalelo noma akhethwe udokotela ukuba khona. Self-nokuphathwa nomuthi futhi (noma) ukusetshenziswa kwalo engalawuliwe ingaholela yokweqisa. The njalo kunazo waphawula zimpawu ezilandelayo: ukucanuzela kwenhliziyo, ukuhlanza, ukopha, pheshana emathunjini, ukozela, ukucobeka, umfutho wegazi ophakeme (high blood pressure), okusithiyayo of umsebenzi zokuphefumula, ukwehluleka oyingozi kwezinso.

Ukwelashwa uma ukweqisa izidakamizwa lingaze, usekela uhlamvu. nimesulide Antidote okwamanje ayikho. Uma kusukela overdosing noma ukuthatha umthamo eliphezulu nomuthi awuphasiswa ezingaphezu kuka 4 amahora, isiguli esibhedlela lavage esiswini reception Kunconywa umswakama (isib carbon ocushiwe inani 60-100 mg umuntu omdala) futhi ezinye izinhlobo osmotic izidakamizwa laxative.

Phakathi naso sonke isikhathi sokwelashwa kufanele ngokucophelela waqashwa bezempilo isibindi nezinso ukusebenza. Ulwazi mayelana nokwenzeka ukususwa nimesulide kusuka emzimbeni by hemodialysis ayitholakali. Ngenxa izinga eliphakeme ngibopha zemithi amaprotheni diuresis ophoqelelwe asiphumeleli.

imiyalelo Special

"Nimesulide" ukuthola imithi emakhemisi okuyinto akudingekile, Nokho, kufanele kuthathwe ngokuqapha. Gwema isicelo parallel we nomuthi futhi yimuphi omunye non-steroidal ejenti eqeda ukuvuvukala, analgesics isikhonzi. With ukuthuthukiswa izimpawu iziguli, ukulimala kwesibindi isici (isicanucanu, ukuhlanza, sokuzincisha ukudla, umchamo onombala) noma ukwandisa ezingeni transaminases hepatic isicelo "nimesulide" kufanele uyekwe. Uma kukhona imfiva noma izimpawu zomkhuhlane, imishanguzo kufanele inqanyulwe ngokushesha.

Uqaphele iziguli zakhe kufanele kube ukuthi parallel "Nimesulide" imithi ukuthatha ukuthi kwandisa ingozi yokungenwa izilonda emathunjini bese ukopha. Okumele kuqashelwe ebekiwe kwezidakamizwa ngabantu abaphethwe izilonda emathunjini noma isifo Crohn, izilonda kokuba umlando ezigulini esezikhulile.

Abantu abadinga ukuthatha "Nimesulide" kanye aspirin ngemithamo inhliziyo kumele yabelwe ukwelashwa nge gastroprotectives.

Ukusetshenziswa "Nimesulide" (noma iyiphi enye NSAID) obuningi futhi lokho kuthatha isikhathi eside kuholela nje ukwenyuka kancane ingozi izingozi thromboembolic (stroke, isilethikusebenza, nokunye. N.).

Iziguli ezihlukahlukene zenhliziyo izinkinga "Nimesulide" uhlelo angaqokwa kuphela uma inzuzo elindelekile idlula ingozi nemiphumela engathandeki yalawo maphilisi.

I nomuthi kuyalithinta degree of umsebenzi platelet. Lolu lwazi Kubalulekile iziguli oluhambisana diathesis. izilonda Sinzima kwesikhumba avame ukuthuthukisa ngesikhathi eside ukusetshenziswa "nimesulide". Uma avele ukuqubuka, uba ukulimala appreciable ukuba nolwelwesi lwamafinyila noma yimuphi omunye ukubonakaliswa fixed ukungabekezelelani, ukwelashwa imithi kufanele ayisekho.

Ukusetshenziswa "Nimesulide" kwabesifazane abakhulelwe kungase kubangele ukuvala lwemithambo imbobo phambi idingeka, ukunciphisa ivolumu ye-amniotic fluid. Okungenzeka kwengozi ukopha intrauterine, kuyadamba zomsebenzi, ukubukeka edema. Ngenxa yalezi zizathu, omama abakhulelwe ngesikhathi kuqala futhi trimesters yesibili yokukhulelwa reception "Nimesulide" is hhayi Kunconywa.

Kufanele kube impendulo yombuzo ophathelene nokuthi sikwazi ukuthatha "Nimesulide" kanyekanye kanye notshwala, kusobala: inhlanganisela enjalo akuvunyelwe!

analogs

Ngaphansi analogs "nimesulide" libhekisela izidakamizwa esuka emaqenjini NSAID equkethe njengendlela eyinhloko esebenzayo isithako nimesulide (ngentengo yabo ngeke oscillate cishe ibanga elifanayo kodwa kancane ngezansi). Esaziwa kakhulu futhi ngokuvamile ebekiwe yezokwelapha abasebenzi analogs zihlanganisa izidakamizwa "Naiz" (ijeli, ithebhulethi, ukumiswa), "Nimesil" (izimpushana) "Niemiec" (amaphilisi) 'nimulid "(ijeli, amaphilisi, amaphilisi ukumiswa for abancela) .

Zonke analogs ifa kahle eyanele futhi ngabelwa ukubhekana ehlukahlukene izifo, ukuvuvukala uhlamvu egqoke.

lebanga lentengo

Amanani yena "Nimesulide" futhi analogs kwakhona cishe abafanayo, nakuba ayengafani sixoxe izidakamizwa izindleko ifinyeleleka kakhulu anhlobonhlobo abathengi. Tablets "Nimesulide" (20 nama-PC. Ngo iphakethe) izobiza ruble 85-90 iphakethe ngalinye. Inani elifanayo amaphilisi "Naiza" izobiza ruble 110-140, "Niemiec" (futhi 20 nama-PC.) - ku ruble 115-134. Okufakiwe "nimulid" amaphilisi 30 kubiza ruble 180-220. Okuqukethwe ivolumu isithako esebenzayo eyinhloko (Nimesulide) kuzo zonke analogs efanayo - 100 mg.

Kunalokho amaphilisi "Nimesulide" (izindleko ephansi) ingatholakala, isibonelo, i-slurry "Naiz" izindleko ruble 200-300 60 ml noma "nimulid" - ruble 75-105 ngoba esilinganayo izidakamizwa. Futhi kuyatholakala anhlobonhlobo abathengi lozenges "nimulid": 20 ukwabelana ngentengo 130-155 ruble iphakethe ngalinye.

Mhlawumbe uhlobo eqolo ukukhululwa zomuthi nge nimesulide njengoba ingxenye main - powder 'Nimesil ". 30 izikhwama (iphakethe) izobiza ikhasimende inani ruble kusuka 560 kuya 645.

Ukuze isicelo nezokusigcoba kukhona si ngempumelelo nge nimesulide. Ngakho, "Naiz" izobiza ruble 120-145 okwesikhathi tube ka 20 g noma ruble 215-275 (50 g). Gel "nimulid" eshibhile kancane: 115-150 ruble ngalinye tube ivolumu '30

Ekuphetheni Ngithanda ukusho lokhu okulandelayo. Isinqumo ukusebenzisa "nimesulide", noma yikuphi Analogue noma yimuphi omunye ama-NSAID kufanele ezithathwe udokotela ukuba khona. Kuphela wezempilo lingabizwa ukuhlola kobukhulu impilo iziguli zabo, ukuba bacabangele zonke isifo ahlobene, khetha umthamo izidakamizwa ukuze ukhethe nokuthuthukisa indlela yokwelashwa ukuze unciphise amathuba okuba nemiphumela engemihle futhi ukuze uthole imiphumela emihle kakhulu.