"Lorista": yokusetshenziswa, intengo, kanye nokubuyekeza. Analogue eshibhile "Loristy"

Enombono extension ebalulekile yokuphila komuntu WHO izazi ukuthuthukisa izinhlelo ukuze silwe nezifo zenhliziyo. I pathologies njalo iningi uhlu lwabo kubhekwa nomfutho wegazi ophezulu. Kuba imbangela kokunqotshwa kwe Imithambo yegazi wonke umzimba. Lena acute kakhulu ubuchopho, inhliziyo, izinso kanye retina. Ngenxa nomfutho wegazi ophezulu kubangela izifo ezingathi sína kwababhemayo, kwandisa ngqo abafa ngenxa yesono sabantu. Futhi, ngenxa eliphezulu blood pressure okuhlale kukhona kunciphisa izinga izimpilo zeziguli.

Ngoba ezweni lanamuhla, ubude bempilo kanye izinga kubaluleke ngempela, isidingo ukulawula umfutho wegazi ophakeme, uvika ukwanda oluqinile futhi njalo ingcindezi. Lokhu kufezwa ngokusebenzisa namakilasi amaningana izidakamizwa: ACE inhibitor, blocker ka-receptor yayo, i-calcium abamelene blocker futhi isisu. Lezi izinto yisisekelo ekwelapheni nomfutho wegazi ophezulu. Futhi lesi sidakamizwa "Lorista" analogue nama esikhundleni, kanye efanayo ketshezi asebenzayo kuhlale kusebenza, engabizi futhi ethandwa izidakamizwa.

izici Jikelele zomuthi

Izidakamizwa "Lorista" esikhundleni iziphi kabanzi amelwe isigaba izidakamizwa antihypertensive, iqukethe losartan. Le into izidakamizwa kuyinto angiotensin yokwamukela blocker Uhlobo lwesibili. umphumela zayo zokwelapha iyona okusithiyayo we yokubopha yokwamukela angiotensin nge endothelial isitsha mediates ukungabi nakwenzeka kwento ekunciphiseni bomkhumbi. Umfutho wegazi ukhulise futhi uhlala ezingeni yasekuqaleni. Ikhishwa izidakamizwa inkampani Slovenian Krka.

Kuyaphawuleka ukuthi "Lorista" - kuba ejwayelekile, futhi losartan yokuqala 'Cozaar'. Kodwa lokhu umuthi nekhwalithi ephezulu, ngakho indlela iyinkampani ukuthi uyayikhathalela umfanekiso waso omuhle. Lokhu kufakazela isifundo sethu bioequivalence 'Cozaar' futhi 'Loristy ", okufakazela ukuphumelela yokugcina endaweni yayo efanele.

Yokusetshenziswa

Njengoba unamathele izidakamizwa "Lorista" imfundo, kobufakazi nesineke nochwepheshe, kanye zokwelapha ukuhlolwa isicelo ukufakazela ukuphumelela izidakamizwa ekwelapheni nomfutho wegazi ophezulu. Futhi ngokwemvelo, ukuthi yokwelashwa okuphumelelayo kakhulu kungenzeka kuhambisana nezincomo ezibekwe yokusetshenziswa. Phakathi bezimiso zawo, amaphuzu alandelayo:

• nomkhakha we izinkomba;

• sokuphuzisa zemithi kanye Ukukhetha umthamo;

• reception izici;

• Izimo;

• izinyathelo zokuphepha.

Ngayinye zoMthetho yokusetshenziswa, bheka ngezansi.

ubufakazi

Zonke ukufundwa kufanele lucwaningwa imiyalelo elandelayo, lapho kuvele njengamadiski uhlu. Umgomo salolu shicilelo bahlale ngokwahlukana iwindi zokwelapha izidakamizwa. Ngakho, "Lorista" isetshenziselwa ukwelapha umfutho ophakeme wegazi kusaqalwa sokuqanjwa phakathi ukuthuthukiswa monotherapy futhi isifuba esomile ekuphenduleni ethola izidakamizwa kusukela iqembu ACE inhibitor. Lesi sakamuva aphumelela kakhudlwana, kuyilapho "Losartan" - engathatha ukuthuthukiswa amathuba okuba nemiphumela engemihle ekusebenziseni kwazo.

Okunye okubonisa kuyinto ekwelapheni nomfutho wegazi ophezulu, degrees eliphezulu ukwelashwa in iziguli okusezingeni eliphezulu ingozi senhliziyo nemithambo yegazi. Lapha, isicelo salo futhi okungenzeka elilinganiselwe nemiphumela emibi ACE inhibitor. Uma kungekho imiphumela emibi, akusiyo ngendlela engcono kakhulu "Losartan" nezinye angiotensin yokwamukela blocker futhi inhibitor of enzyme.

"Lorista" kuboniswa ngoba impatho yinhliziyo kwezinye iziguli Abaphunyukayo umphumela wawubona antihypertensive ekwelapheni enzyme inhibitor. Futhi, khona ngesifo sikashukela "Losartan", intengo iphansi ngokwanele, umuthi lokuzikhethela. Nokho, lokhu kungenzeka ukungabekezelelani ukuba ACE inhibitor, okuyinto nje leyo ndawo ilahlekelwa potency ukuqala inciphise umfutho wegazi ophakeme isivinini.

Umthamo lwemithi futhi Ukukhetha umthamo

Noma yimuphi Analogue "Loristy" kukhethiwe ngokuqinile ngamunye. Nor is ashila umane akukwazi ubuhlobo ocacile phakathi degree of nomfutho wegazi ophezulu kanye umthamo we izidakamizwa. Kwangathi khona kuphela amaphethini ezinye elihlobene ne kobukhulu isifo ecashile. Ngo umfutho wegazi ophakeme, ngezinga lokuqala okusezingeni eliphezulu kakade ingozi zenhliziyo bangakwazi ukunikeza 12.5 noma 25 mg "Loristy" ngosuku. Nokwanda degree of nomfutho wegazi ophezulu siyakhula futhi umthamo.

Lapho belungela ukuya khona "Losartan" intengo - lena okungenani esibalulekile kokukhetha ethile egameni lendawo yokuhweba noma. Isikali ezibalulekile Njalo kuphela. Futhi kungaba afinyelela 200 mg ngelanga ihlukaniswe ngemithamo ezimbili. Umbandela ka ukuphumelela ukwelashwa - amazinga blood pressure egculisayo. Lapho-systolic blood pressure phakathi ukwelashwa aliphumi ngenhla 140, umthamo inikezwe zomuthi eyanele ukulapha.

Endabeni CHF kanye nokuntuleka nomfutho wegazi ophezulu ukuqashwa kukaNksz ACE inhibitor noma ARBs Kuyadingeka ngenjongo nokucindezela esivimba amanzi cystic izinqubo. Kulokhu, lesi sidakamizwa sabelwe esiphezulu ibekezelelwe umthamo. It is titrated kuye ngokuthi ezingeni ingcindezi, ngakho-ke awehleli ngezansi 110.

side effects

Izidakamizwa "Lorista" ukusebenza ngomhla ka-izindlela begazi ingcindezi imigomo, futhi ngenxa yalokho abanye imiphumela emibi. Ezinye zazo yabangela imiphumela anobuthi kwesibindi, uhlelo hematopoietic. Okuvame kakhulu, ukuthi, ezithinta cishe 1.7% eziguli, imiphumela emibi ibandakanya: ubuhlungu phezulu esiswini, ukukhathala noma ukuba buthakathaka, ukuthuthukiswa ebusweni futhi emikhawulweni edema. Ukuze uqhathanise, izigameko -placebo impendulo correlates nge imvamisa yale miphumela engemihle, ngenxa lapho ukulungiselela kubhekwa ephephile kunemibandela.

"Lorista" ezingavamile, ie-1% izimo, kubangele palpitations inhliziyo. 2% iziguli bathambekele akhononde ukuthuthukiswa sohudo ngemuva kokuthatha izidakamizwa, "Losartan". Intengo kokuma enjalo sincane kakhulu, ngoba isibalo Ezimweni ezinjalo incane. By the way, ngisho ngaphandle kokusebenzisa imithi, kodwa kuphela ngenxa yokuthi uhudo placebo kanye dyspepsia ithuthukiswe 1.9% eziguli.

Akuvamile, iziguli okungenani 1 100 waphawula ukubukeka ubuhlungu bemisipha, iqolo, ukuthuthukiswa kwemisipha amajaqamba. Lokhu isimo akuyona labizwa ngokuthi myopathy okudalwe ukusebenzisa "Losartan". Lona nje indlela evamile, okuyilona elisebenzayo futhi nasemkhakheni iqembu ukuqhathanisa. Umuthi is kahle ibekezelelwe ngempela lula kunalokho "Lorista H" futhi "Lorista" ND "kusukela emibi yawo phakathi labo izimo lapho zibangelwa ngaphezu kwalokho hydrochlorothiazide. Naphezu kwakho konke lokhu, zonke izinketho ezintathu "Loristy" ephephile futhi ebalulekile umkhuba zokwelapha.

Izimo

Zonke analogue "Loristy" futhi "Cozaar" kuhlanganise "Lozap" imfundo (intengo esibalulwe ngezansi) eyenqabela ukusetshenziswa kwalezi zimo:

• e ukuthuthukiswa ukusabela iguliswa noma yikuphi amalungiselelo equkethe "Losartan";

• izingane ezingaphansi kweminyaka engu-18 ngenxa yezinzuzo unproven futhi engaziwa side effects kulezi iziguli;

• phakathi nokukhulelwa kanye lactation.

Iziguli izilonda kwezinso izidakamizwa itholakale "Lorista" singasebenza, njengoba ngcono kwezinso ukugeleza kwegazi bese isihumusha umphumela nephroprotective. Futhi, "Losartan" kuyinto eliphuphile, kodwa umphumela ozuzisayo: it ngesivinini excretion of uric acid, kuka ukubambezela ukuthuthukiswa exacerbations ka sifo. Nokho, it is kusetshenziswe ngokuqapha e yokwehluleka kwesibindi. Lesi simo emitholampilo kuthathwa njengesibikezelo esiyiso contraindication isihlobo.

Izici reception

Umuthi 'Lorista "," Lozap "," Bloktran', 'Cozaar', 'Vazotenz "intengo lihlukile, kodwa izici ezifanayo isicelo. Ikakhulu, i-izidakamizwa esithathwayo once ngezinga ezinhle ukulawula umfutho wegazi noma ngesikhathi ongaphakeme okwandisa ke. Uma umfutho wegazi ophakeme kakhulu, nge okhuphukela njalo, kudinga ukusetshenziswa "Losartan" kabili. Kuyinto efiselekayo njalo ukusebenzisa izidakamizwa ngesikhathi esifanayo, okuyinto ngcono enegunya elithile lokulawula ingcindezi futhi isibikezelo Yiqiniso isifo.

Izidakamizwa "Lorista" ingase ikhishwe ngaphandle kokubheka ukudla, ukuphuza isilinganiso esifanele amanzi. Esikhathini isabelo eyinhloko antihypertensive yayo eba kancane kancane futhi ifinyelela isiqongo amasonto kuphela emva 1-2. Kulesi "Losartan" kanye nabanye (ARBs) angiotensin yokwamukela blocker kakhulu eliphansi kuya Ace inhibitor. Nokho, ARBs babe isici esibalulekile - ayinayo imithelela emibi ezifana isifuba esomile ngenxa ekuqongeleleni bradykinin. ARBs nazo libhekene engekho umphumela isenzo antihypertensive yokuphunyuka, okuyinto sici ukusetshenziswa kwesikhathi eside ACE inhibitor.

Ukukhishwa

"Lorista" itholakala amaphilisi, ne igobolondo kanzima. Imithamo zinqunywa mass "Losartan" ekhona iphilisi elilodwa. Kunezinhlobo ezintathu ongakhetha "Loristy" esenikwe 12.5, 25, 100 mg. Waqaphela futhi ukulungiselela elihlangene ngaphansi kwalesi tradename yakhiwa izinto ezimbili asebenzayo "Losartan" futhi "Hydrochlorothiazide", okuyinto kuhlanganiswe nomunye. Zitholakala ku imithamo ezilandelayo:

• mg 100 losartan + 12.5 mg hydrochlorothiazide - ukulungiselela "Lorista H100";

• 50 mg losartan 12.5 mg hydrochlorothiazide + - izidakamizwa "Lorista H";

• mg 100 losartan + 25 mg hydrochlorothiazide - ukulungiselela "Lorista ND".

Ngo amaphilisi, nge umthamo ezifanayo ukudayiswa kanye nanoma yimuphi Analogue "Loristy" bengena inethiwekhi ekhemisi.

"Loristy» Inani

Umuthi 'Lorista "intengo kuyahlukahluka kwezinye izindawo kuleli zwe. It kuncike izici ukunikezela ukufinyelela ukuqaliswa. Umuthi uhlale ezishibhile emizini, lapho kukhona izikhungo ukuhlolwa nompetha izidakamizwa. Njengoba ngayinye kwemikhiqizo zokwelapha, kungakhathaliseki ukuthi amazwe noma zasekhaya, kumele kudlule esigabeni test of the party, kungokwemvelo ukuthi kuleli zwe ke ushibhile enhloko-dolobha. E-Moscow, amaphilisi 30 zomuthi "Lorista" intengo simiswe ngalendlela lelandzelako:

• "Lorista 12.5 mg" ayelingana 100-150 ruble;

• "Lorista 25 mg" kuwufanele ruble 160-210;

• "Lorista 50 mg" kuwufanele ruble 180-270;

• "Lorista 100 mg" - ruble 270-330;

• "Lorista H" (50 mg) - ruble 250-300.

Ukulungiselela "Lorista" ingcindezi ezase 30, 60 noma 90 amaphilisi. Iziguli kusiza izidakamizwa ukulawula ngempumelelo nomfutho wegazi ophezulu, kungenzeka ukuthola ukuthi ngabe iphakheji elikhulu. Lena kwezomnotho kusiza, ngoba amaphakheji ezintathu amaphilisi 30 Uyi kokukodwa iphakethe amaphilisi 90.

Eshibhile analogue "Loristy"

Inkampani Krka kuyahlonishwa umthengi, ngoba izidakamizwa ezivezwa ke ukuhlangabezana nezidingo zokwelapha. Nokho, izinga yabo lufakazelwa izifundo bioequivalence kuya "losartan" wethu wakuqala - "Cozaar". Nokho, kunezinye imikhiqizo equkethe "Losartan". Lapho belungela ukuya khona "Lorista" analogue nama esikhundleni kungenzeka eshibhile. Ngo Izibonelo "Vazotenz", "Bloktran", "Prezartan".

Analogue eshibhe - "Bloktran", onikeza ku yinkimbinkimbi ifomu ngomthamo, kodwa has a kusebenta efanayo ngokuthi "Lorista". "Vazotenz" kancane eqolo ngaphezu kwanoma "Bloktran", nakuba cishe ukusebenza efanayo. Umbandela Ukukhetha kulokhu ukuyikhokhela. Ngesikhathi esifanayo lesi sidakamizwa "Bloktran" ukufundwa ezifanayo nalezo kwanoma iyiphi analogue equkethe "Losartan". Lokhu kungokwemvelo.

kumakhophi Commercial "Loristy"

Kunemithi eminingi eziqukethe "Losartan" njengoba izidakamizwa esebenzayo. Sinenkosi amanani ahlukene futhi izinga. Kulokhu, iyiphi analog we "Loristy" kodwa izidakamizwa 'Cozaar' iyona ejwayelekile. "Lorista" - futhi ikhophi ilayisensi ye "Losartan" yasekuqaleni - isidakamizwa 'Cozaar'. Ngakho-ke, i-ukuqhathanisa, ngesisekelo intengo nekghono enomqondo ukuthatha ke izidakamizwa yokuqala, ekhiqizwa yinkampani Swiss Merck SHARP & DOHME IDEA, Inc. Phakathi nozakwabo kwezohwebo "Loristy" izidakamizwa samanje izigaba ezintathu intengo:

• intengo ephakeme ( "Cozaar" "Amzaar" "Gizaar");

• cishe amanani efanayo ( "Losartan-Teva", "Losap" "Lorista" "Centaur");

• izidakamizwa eshibhile ( "Losartan NAS," "Losartan-Richter," "Losartan Belmedpreparaty", "Prezartan", "Bloktran", "Vazotenz").

Inani amalungiselelo isigaba sokuqala ububanzi ruble 500-1000 lokugoqa amaphilisi nge okuqukethwe 30 "Losartan" 100 mg 50. Inhlanganisela amalungiselelo ehlanganisa 25 noma 12.5 mg "hydrochlorothiazide" kanye 100 noma 50 mg "Losartan", ngokulandelana, amayelana 800-1000 ruble amaphilisi 30.

Amalungiselelo maphakathi no-ontengo yakhe yayinqunyiwe cishe zivumelana intengo "Loriste". Noma yimuphi analogs ezinjalo "Loristy" angena range intengo ruble 300-600, kuncike umthamo kanye ngokuhlanganisa ne "hydrochlorothiazide". A imikhiqizo ontengo yakhe yayinqunyiwe aphansi nibaluleke ngama-300 kuya - 400 ruble, okuyinto edingekayo ukuze inkambo yenyanga yokwelashwa.

Izindleko-eziphumelela kakhulu lesi sidakamizwa "Lorista", "Centaur", "Lozap" "Losartan National Academy of Sciences." Phakathi izindlela ayatholakala ngentengo lokho imithi engcono. ozithandayo Sinemibandela phakathi yimuphi "Losartan" esuselwe - ukulungiselela "Cozaar," okuyinto original. Nge ukusebenzisa kwayo ukusebenza kungase kutholakale, "Losartan" njengoba ejenti antihypertensive.

Izibuyekezo Ochwepheshe

Ochwepheshe ngempela kahle lesi sidakamizwa "Lorista", ngoba ukusebenza kwalo kungase kutholakale isifundo bioequivalence 'Cozaar'. Ngenxa kucatshangwa ukuthi "Lorista" - ushibhile yokuqala 'Cozaar'. okubuyayo ongoti abangu hola ngenxa yokuntuleka kusebenta isinyathelo antihypertensive yokuphunyuka. Nokho, izidakamizwa, kukhona nemiphumela ethile engathandeki ukuba ekilasini angiotensin yokwamukela blocker. umphumela wabo kancane, okuyinto kuvimbela ukuqhubeka ngokushesha ukwelapha amandla okusezingeni eliphezulu nomfutho wegazi ophezulu noma ukusebenzisa imithi lapho ezihluzekile ngesikhathi sezinhlekelele.

nobufakazi

Ngezinye yokuvuma njalo, weziguli wabika inombolo encane side effects, musa ihluke izibalo ezishiwo imiyalelo enamathiselwe. Umuthi kahle futhi nombala ukulawula umfutho wegazi, ngenxa okuyinto kwehlisa amathuba ezihluzekile ngesikhathi sezinhlekelele. Futhi, iziguli besilisa libike ukuthi "Lorista" akusenzi potency, njengoba kunjalo ACE inhibitor. Ngokuvamile, "Lorista" libhekene njengendlela yokuthola okunokwethenjelwa futhi iphephile ukwelapha umfutho ophakeme wegazi.