Izidakamizwa "Arlette": yokusetshenziswa, Izimo, ukwakheka kanye nokubuyekeza

Uma ukuthuthukiswa penicillin elula baba panacea for eziningi izifo ezibangelwa amagciwane abantu ezimweni eziningi yafa. Kusukela ngaleso sikhathi, isintu besilokhu transcended kolunye eyinkulungwane itfutfukise zotshwala elwa namagciwane njengoba ezibanzi-spectrum, futhi ebucayi kunoma ifakelwe uhlobo lwe-silwanyana ukuphi. Elinye ithuluzi sinjalo "Arlette". ekusetshenzisweni lo mhlahlandlela imithi iqukethe ulwazi olunzulu mayelana yonke impahla yayo.

Ukwakheka ejenti elwa namagciwane

Izingxenye ezisemqoka kukhona trihydrate amoxycillin (esibaliwe amoxicillin kungenzeka amavolumu 250, 500, 875 mg) ne-potassium clavulanate (ivolumu - 125 mg, esekelwe clavulanic acid). Uphiko sokuqala ubizwa ngokuthi uchungechunge nge-penicillin akuzange semisynthetic, elinesimo ensimini letinengi umsebenzi elwa namagciwane. Eyesibili ingxenye enkulu ye nomuthi kuyinto inhibitor engelapheki we-beta-lactamases.

Ngaphezu kwalokho, eziningi izakhi asizayo lenye izidakamizwa "Arlette". Yokusetshenziswa, incazelo ukulungiselela kulethwa ukunakwa abathengi ukuthi zikhona ukwakheka ephansi yamangqamuzana isisindo core povidone, isitashi pregelatinized, i-calcium stearate, microcrystalline cellulose futhi talc. Futhi lokhu akuyona yonke.

Kumiswa bezinhlamvu is-antibiotic hypromellose, propileglikol kanye polyethylene glycol 4000 (macrogol noma 4000), ama-titanium dioxide. IMisa umsindo «Arlette" amaphilisi (imfundo manual inalokhu Imininingwane) 600, 1100 noma 1600 mg.

pharmacodynamics

Njengoba kushiwo ngaphambili, "Arlette" kuyinto eyinkimbinkimbi amoxicillin futhi clavulanic acid. Amafomu yokugcina esitebeleni eziyinkimbinkimbi inactivated beta-lactamases (enzyme webhaktheriya Umsebenzi oyinhloko esakhiwa ekulweni beta-lactam antibiotic, emazweni amaningi isetshenziselwa Elwa Namagciwane Ukwelashwa ngamakhemikhali - cephalosporin, penicillin akuzange kusize, njll ...). Beta-lactamases banesibopho ukudalwa ukuphikiswa ophikelelayo kuze amadivaysi ezokwelapha esesikhulume ngazo.

Ngu uqobo, clavulanic acid, ogama isakhiwo siyafana we-beta-lactam izidakamizwa, elinesimo amakhono elwa namagciwane kunalokho ebuthakathaka siqu. Noma kunjalo, khona acid "Arlette" amoxycillin ekwakhiweni umelana ekubhujisweni futhi kukhulisa indawo amathuma elwa namagciwane, kuhlanganise kuwo ama-bacterium nezilwanyana ezincane amelana ejwayelekile izimo umthelela amoxycillin, ezinye izindlela amaqembu penicillins futhi cephalosporins.

Ama-antibiotic "Arlette" yokusetshenziswa njengoba nomuthi ulawula ebanzi ukuchayeka ndawo. He is asebenzayo ngokumelene ukungenwa amoxicillin nesigqi (hhayi ngaphandle kwaleyo synthesize beta-lactamase). Lezi zihlanganisa uhla amagciwane aerobic kanye anaerobic igremu-HIV futhi igremu-HIV.

Izinkomba "Arlette" kusho

Field umphumela ku -ejenti elwa namagciwane kunalokho enkulu, kuyaphumelela eziningi ezahlukene izifo etymology. "Arlette" yokusetshenziswa izimvume ukusebenzisa ekusombululeni tinkinga elingenhla ipheshana zokuphefumula bese engenhla ipheshana zokuphefumula. Ikakhulukazi sikhuluma amafomu oyingozi futhi ezingalapheki sinusitis futhi otitis abezindaba, a namathansela, pharyngitis, abscesses endaweni retropharyngeal. Umthelela omuhle nomuthi wokwelapha izifo has uhlelo zokucinana, okuhlanganisa ukucinana kwemigudu yokuphefumula (chronic acute, ephelezelwa superinfection webhaktheriya) kanye nenyumoniya.

Nokho, akunjalo zonke izindawo lapho Arlet isicelo. Yokusetshenziswa, imithi incazelo babike ukusebenza yayo ekwelapheni izifo kohlelo genitourinary nezitho okhalo. Izifo ezihlala zihlanganisa pyelonephritis, prostatitis, urethritis, endometritis futhi lezinkinobho webhaktheriya, isisu ukonakala, isipatsholo m. P.

Futhi kahle unomthelela lo muthi ekwelapheni isikhumba futhi izicubu zomzimba ezithambile izifo bezizinda ezihlukene (abscesses, cellulitis, Erysipelas, impetigo, ebusweni ukulimaza kanye kabusha itheleleke dermatoses ukutheleleka). "Arlette" ingasetshenziswa ekwelapheni amathambo zezinzwa kwezicubu, biliary ipheshana prolechivanii (cholecystitis, cholangitis), e izilonda odontogenic, ukuvimbela izinqubo ukuvuvukala kule ukuhlinzwa, nezikhathi nasezinkingeni ezilandela ngemva kokuhlinzwa.

Isikali nezindlela kwesicelo

Ukuze izidakamizwa "Arlette" indlela yokusetshenziswa futhi umthamo zinqunywa ngamunye futhi sincike yobudala, isisindo, isimo izinso nokugasela ukutheleleka. Ukuze unciphise amathuba nemiphumela emibi pheshana emathunjini, ithebhulethi okufanele zithathwe ngaphambi kokudla, sisonke, musa ukuhlafuna futhi aphuze amanzi.

Iziguli engaphezu kwengu-12 ubudala noma nge isisindo umzimba 40 kg nokukhanya ungamela izifo amafomu ukuthatha ithebhulethi eyodwa (250 mg isakhi esiyinhloko) kathathu ngosuku noma kabili ngosuku (500 mg amoxycillin). Ngo yokulimala kabi athathe umthamo okulingana 500 mg amoxicillin kathathu nsuku zonke noma 875 mg - kabili emini.

Iziguli engu-6 kuya 12 "Arlette" imfundo manual uncoma, esekelwe isisindo 1 kg amoxycillin - 20-30 mg Clavulanic acid - 5-7.5 mg. Ngokuvamile, umthamo lezi iziguli 1 tablet (250 mg) kabili noma kathathu ngosuku noma 1 ithebhulethi (500 mg) kabili ngelanga. Ezimweni ezimbi kakhulu, umthamo kungenzeka kabili.

Ezigulini ezine-kahle izinso umsebenzi in umthamo kanye nokushintsha kokudla nokufakwa imvamisa kuyalungiswa kuncike imvume creatinine. Labo abaphethwe anuria, ngezikhawu phakathi ukudla kumele lenyuke amahora angu-48 noma ngaphezulu. Ezigulini othola hemodialysis, inani nomuthi ezikhethiwe kusuka umthamo esiphezulu amoxycillin.

Abantu abanokukhubazeka ekusebenzeni kwesibindi ngokuqapha izidakamizwa "Arlette". Yokusetshenziswa (abstract), ukubuyekezwa wochwepheshe bezempilo Kunconywa ukuba ngokuqhubekayo nokuqapha isimo umzimba.

Ukuze ezigulini esezikhulile ukulungiswa umthamo liyadingeka.

side effects

uhlu Specific amathuba okuba nemiphumela engemihle kuhlanganisa imithi elwa namagciwane ngoba "Arlette" imfundo manual. Ukwelashwa (nesineke impendulo qinisekisa) leli thuluzi kungaba avuse eziningi ngeziphambeko kusukela ipheshana emathunjini ngesimo yokuntuleka esesuthi, isicanucanu, ukuhlanza, ukukhishwa isisu. Ngezikhathi ezithile ungezwa mayelana isibindi babantu, kodwa okungenani - on ukuthuthukisa i-jaundice cholestatic, isifo sokusha kwesibindi, nesifo pseudomembranous.

Basabela kanjani isimiso sezinzwa esiyinhloko ukuba ukusetshenziswa "Arlette" izidakamizwa wayesengaba ikhanda nesiyezi, hyperactivity (ngesimo esethola) nomsebenzi kokuquleka.

uhlelo hematopoietic angaphendula ukubonakala izimpawu leukopenia igazi hemolytic, agranulocytosis. Kungase kwandise isikhathi prothrombin (kuleli cala, inqubo esethola). Crystalluria futhi nephritis interstitial - akwenzayo kungase kubathinte kanjani isidakamizwa kusukela uhlelo urinary.

uhlu ngokwanele ezibanzi kungenzeka komzimba nezinto lo muthi 'Arlette ". Imiyalelo, incazelo lomuthi wazise abathengi mayelana nentuthuko okungenzeka pruritus, urticaria, ukuqubuka erythematous. Ngezikhathi ezithile ungezwa ngezimpawu ze- exudative erythema multiforme, angioedema, ukushaqeka anaphylactic. Kukhona ulwazi mayelana ukubonakaliswa ngabanye amathuba okuba nemiphumela engemihle ngesimo Stevens-Johnson syndrome, futhi dermatitis exfoliative.

Izimo ukusetshenziswa "Arlette"

Uhlu izizathu ezenza kungabi nokusetshenziswa kwamaphilisi, ngokuba nomuthi yakhiwa "Arlette" imfundo manual. Izimo nomkhawulo reception kulabo iziguli enibhekene hypersensitivity ngakunye izingxenye eziyinhloko and uphiko zomuthi kwamanye ejenti beta-lactam elwa namagciwane (penicillins, cephalosporins nokunye okunjalo. P.). Hhayi esabelwe 'Arlette "nalabo abanomthwalo umlando okuqoshiwe ekusebenzeni Ukuhlukumeza ekwelapheni isibindi amoxicillin futhi clavulanic acid eziyinkimbinkimbi. Imithi contraindicated labo abaphethwe mononucleosis futhi lymphocytic wegazi, njengoba kwandisa amathuba wokuthuthukisa exanthema.

Wokwalelwa ukwelashwa nale-antibiotic kukhona ezingamahlalakhona ukwehluleka kwezinso nezingane kuze iminyaka 6.

Njengoba kwabesifazane abakhulelwe, zingathatha "Arlette" kuphela uma izinzuzo unina indisputably mkhulu kunezinhliziyo ingozi beqonda ezingenzeka embungwini. Lapho lactation yezingxenye eyinhloko izidakamizwa nengcosana ngobisi, ngakho kufanele uxoxe nodokotela wakho umbuzo yokwenqaba ukuncelisa.

Ukweqiwa ngokweqile

Iziyaluyalu ipheshana yesisu - okungukuthi eqenjini eyinhloko izimpawu nobuntu ngemva kokudla izidakamizwa ngokweqile, "Arlette" (tablet). Yokusetshenziswa, kobufakazi nesineke babike ukuhlanza, ukukhishwa isisu, ubuhlungu esiswini. Ngaphezu kwalokho, kungase kube nezimo ezifana ukuntula ubuthongo, kanye isiyezi, ukuyaluza. Akuvamile kakhulu ukuzwa nokuquleka.

Lapho izimpawu ukweqisa izidakamizwa i isixazululo eliphezulu nesineke - kwenziwe ngaphansi kokuqondisa of onguchwepheshe. Ukwelashwa nokuvikelwa Ezimweni ezinjalo lingaze.

Uma eqinisweni ekutholeni umthamo engamukelekiko kwakukhona amahora kungekho kuka 4 edlule, kubalulekile ukuba iphume esiswini futhi ngidle izidakamizwa, adsorbents (ezifana namalahle ocushiwe) ukuze sinciphise ukumuncwa. Kususwe kusuka emzimbeni amoxicillin futhi clavulanic acid hemodialysis ngempumelelo.

Ukuxhumana nezinye izinto nemithi

Ngo ukuvuma parallel "Arleta" futhi "methotrexate" kuzokhulisa ubuthi lakamuva. Kakhulu ziyancipha futhi wehlisa ukumuncwa ukuphathwa antacids, glucosamine, aminoglycosides. Ascorbic acid, kunalokho, ukwandisa ukumuncwa - ulwazi olufana kuhlanganisa ama-antibiotic "Arlette" imfundo manual.

Intengo imithi luyehluka kuye umthamo kanye esifundeni, kodwa ziyatholakala anhlobonhlobo abathengi. Ngakho-ke kubalulekile ukuba bonana nodokotela wakho kuqala, futhi ungenayo ukuhlanganisa nokusetshenziswa kwamaphilisi nezinye izidakamizwa.

"Arlette" ukusondela umphumela coagulants ngenxa okusithiyayo we microflora emathunjini, ukunciphisa ukukhiqizwa vitamin K kanye nokunciphisa prothrombin Inkomba. Ngo lokumamukela parallel izidakamizwa, anticoagulants kubalulekile ukuba ngokuqhubekayo nokuqapha kwemigomo igazi ekunqandeni. ukusebenza Unciphise zokuvimbela inzalo ngomlomo.

Ama-NSAID, isisu kanye nezinye amalungiselelo yezokwelapha abacindezela uketshezi ijabulise, anda lokuhlushwa igazi amoxicillin.

Tandem "Arlette" nge "Allopurinom" kungabangela ukuthuthukiswa exanthema. imithi elwa namagciwane amagciwane kuholele synergism nezidakamizwa ne indlela bacteriostatic ithonya - ukuba umbango.

imiyalelo Special

Ngenxa yokuthi imithi "Arlette" (incwadi yeziyalezo iqukethe ulwazi ezifana) nge amazinga okukhishwa ezahlukene amoxycillin zihlanganisa, Nokho, inani elifanayo clavulanic acid (125 mg) kumele kukhunjulwe ukuthi izibhebhe ezimbili 250 mg amoxicillin neze okulingana esinye isibhebhe sibonisa 500 mg ketshezi.

Kufanele kukhunjulwe ukuthi esiningi amoxicillin kungacupha asabele kahle amanga uma izama ezingeni glucose in umchamo uma esetshenziselwa ukuhlaziywa amathuluzi, ezifana Benedict sika reagent noma isixazululo ukugawula. Kungcono ezimweni ezinjalo ukusebenzisa ukusabela enzymatic nge glucosidase.

Ngezinye isicelo amazinga ama-antibiotic oludingekayo ukuze sihlale njalo siqaphele isimo nemisebenzi igazi, isibindi kanye nezinso. "Arlette" ibe yisikali Kunconywa akuphazamisi ikhono lokuphatha nokwenza imisebenzi umgwaqo ezidinga ukunakwa nesivinini eliphezulu lengqondo ukusabela.

Inani Ibanga futhi umbono umthengi mayelana izidakamizwa

Ulwazi on the imithamo okungenzeka izingxenye eyisisekelo izidakamizwa iqukethe i "Arlette" (tablet) yokusetshenziswa. Inani, njengoba kushiwo ngaphambili, kuncike umthamo kanye esifundeni lapho nomuthi lutholwa. Ngokwesibonelo, amaphilisi ifilimu camera umthamo 875 mg + 125 mg eMoscow angathengwa isamba kule uhla ruble 270 kuya 310 (14 izingcezu iphakethe ngalinye). Petersburg iphakethe efanayo izobiza ruble 278-282.

Ngokuphathelene ukubukwa iziguli mayelana nomkhiqizo okwelapha kokubili okubuyayo ezingezinhle mayelana izidakamizwa. Iqembu elikhulu leziguli sikhombisa umphumela omuhle ekwelapheni izifo engenhla ipheshana zokuphefumula bese engenhla ipheshana zokuphefumula. Imithi ngokushesha nangempumelelo sibhekane ngokuphumelelayo sinusitis, futhi athethelelwe lide ngokwanele ke. ukusebenza kwalo ekwelapheni izifo ezithathelwanayo ezibangelwa amagciwane nazo kuqinisekiswa iziguli isibuyekezo.

Izibuyekezo ezingezinhle mayelana nomkhiqizo zokwelapha "Arlette" avame ngenxa yokuba khona iziguli hypersensitive kuya izingxenye izidakamizwa. Ezimweni ezinjalo, abantu bavame ukukhuluma ngeziphambeko ukusebenza ipheshana wokugaya ukudla, ezifana: ukuqunjelwa, ukucanuzela kwenhliziyo nokuhlanza, isifo sohudo. Mayelana yimuphi kwezinso kakhulu cishe akukho lwazi.

Nokho, kufanele kusho ukuthi uma ejenti elwa namagciwane umiswe udokotela ukuba khona futhi nabo wacosha umthamo elilungile, izinhlobo ezahlukene uhlangothi ukuphambuka zenzeka kakhulu akuvamile. Uma into ethi ayifane naleyo kwenzeka, udokotela ayoyikhetha ezifanayo ithonya kanye nokwethulwa ngokuyiko kwezinhlelo inzuzo analog emakethe ezithaka imithi Russian elicwile imithi elwa namagciwane nge spectrum ezibanzi yesenzo.