"Itraconazole": imfundo, ezishibhile analogue, ukubuyekezwa kanye ukukhululwa fomu. Analog "itraconazole" amaphilisi. "Itraconazole" (wamafutha): nozakwabo

Ukulungiselela "Itraconazole" (ithebhulethi, amafutha, ukhilimu, isixazululo noma amaphilisi) isetshenziselwa ukwelapha izifo ezihlukahlukene fungal. Ngesikhathi esifanayo kuba ngokulinganayo ngempumelelo ekwelapheni izifo zazo ukuba isebenze izingxenye ezihlukahlukene zomzimba.

Ingqikithi izidakamizwa

Ukulungiselela uqobo futhi iyiphi Analogue "Itrakanozola" libhekisela isigaba triazoles antifungal. Lesi sidakamizwa eyayenziwe kwemiqondo kuvimbela synthesis ergosterol kwadingeka kwezinhlelo ukusebenza evamile isikhunta. Izidakamizwa "Itraconazole" suppresses le dermagofitov ukuthuthukiswa, nembiliso ka Candida, isikhunta nezinye Amagciwane. Ezinye amagciwane nezilwanyana ezincane amelana lokhu ejenti.

Ukulungiselela "Itraconazole" itholakala amaphilisi, amaphilisi, njengoba isixazululo (liquid) wamafutha. Ukuthengiswa ikude ezingaphezu kweyodwa Analogue "itraconazole". amalungiselelo Okufanayo ayatholakala ezihlukahlukene umthamo.

Noma yimuphi Analogue "itraconazole" futhi, eqinisweni, ukulungiswa ngokwayo kuvame kakhulu ukuba kusetshenziswe i-ukwelapha izifo fungal umgudu wokuphefumula, ikakhulukazi emaphashini. Le mithi asetshenziselwa nokwelashwa kweziguli owabulala isikhunta emphinjeni, ngalo ingaphakathi ngomlomo noma emphinjeni. Isikhathi esining impela, ukutheleleka kuthinta izinzipho womuntu. Kulokhu, sebenzisa ezahlukene ngomthamo ifomu "Itraconazole" izidakamizwa - amafutha ukusetshenziswa yangaphandle, okuyinto ngempumelelo ephatha ukutheleleka fungal sezipikili noma isikhumba. Wakhe anqunyiwe psoriasis.

izinkomba

Lesi sidakamizwa futhi analogue yayo asetshenziswa lezi zifo ezilandelayo:

• umbandamu;

• candidiasis;

• sporotrichosis;

• pityriasis versicolor;

• onychomycosis;

• blastomycosis;

• cryptococcosis;

• keratomikoz;

• paracoccidioidomycosis;

• aspergillosis eluhlelweni kanye candidiasis;

• histoplasmosis;

• mycoses ezishisayo.

Isikhathi ukwelashwa kungase kushintshwe kuye ngokuthi isithombe emtholampilo. Ngokuvamile, lokhu imithi okufanele zithathwe esisodwa ngosuku. Elivame ukusetshenziswa kakhulu yokwelapha izinhlobo zemithi:

• chromophytosis: emkhatsini weliviki, abuye 200 mg;

• umbandamu: emkhatsini weliviki, abuye 200 mg noma 100 mg izinsuku ezingu-15;

• onychomycosis 3 izinyanga ka mg 200 masonto onke noma 200 izikhathi mg / 2 ngosuku;

• tinea izandla nezinyawo: ngesonto 200 mg noma 100 mg inyanga engu-1;

• candidiasis: izinsuku ezingu-15, mg 100;

• keratomikoz: 3 amaviki ka mg 200.

Izindlela ze-reception izifo yamaphaphu

Ukuze ekwelapheni izifo fungal "Itraconazole" umgudu iqondiswa amaphilisi noma amaphilisi. Analogs ishibhile, kodwa bangase babe ezikude ngesikhathi isenzo, ngakho lesi sifo nzima ukuwina ngokushesha ngangokunokwenzeka. Tablets noma amaphilisi athathwa ezikhathini 1-2 ngosuku, ngesikhathi noma ngemva kokudla. Ngokuvamile, ukuze kwelashwe ukutheleleka fungal kwamaphaphu kudingeka okungenani ube izinyanga 3. Kwezinye izimo, lo Udokotela angase anikeze isiguli inkambo esilandelayo yokwelashwa: amaphilisi 3 ngosuku izinsuku 3, kulandele izinyanga 3 1-2 amaphilisi ngosuku.

Ukuthatha izidakamizwa nail ukutheleleka

Izidakamizwa "Itraconazole" - ngamaphilisi kuyabekwa ekwelapheni fungal nail izifo. Ukuze uthole ikhambi eliphelele uphuzwe 1 isikhathi ngosuku amasonto 12. Okuningi ngempumelelo ikhambi ngomlomo "Itraconazole". Uphuzwe amasonto 1-4, izikhathi 1-2 ngosuku. Ngaphezu kwalokho, i-ukumuncwa ngokushesha zomuthi kudliwe on esiswini esingenalutho. Khetha elilungile kakhulu nokushintsha kokudla nokufakwa kohlelo noma aqoke Analogue "itraconazole" kuphela abazokwazi ukuya kudokotela, oyokwenza okuthile ngale ku-akhawunti kuleli cala kobukhulu isifo futhi isimo jikelele isiguli. Emacaleni angu-olunzima kakhulu ukuze yelaphe izifo fungal sezipikili wasebenzisa enye indlela "Itraconazole" izidakamizwa - amafutha ukuthi isetshenziswa endaweni ethintekile izikhathi 1-2 ngosuku.

Okunye embodiments zomuthi

Noma yimuphi Analogue "itraconazole" yena lokhu izidakamizwa eminyakeni yamuva ngokwethukela kusetshenziswa kakhulu ekwelapheni izinhlobo ezahlukene izifo fungal ezigulini abathintwe yi-HIV ne-AIDS. Kulokhu self engamukeleki, ngoba kuphela Udokotela angakwazi ukubona kahle ukuhlola impilo lesiguli kanye nokwenzeka ethola "itraconazole" izingozi.

Izixwayiso

Izidakamizwa "Itraconazole" analogue lomutsi okufanele zithathwe ngokuhambisana imiyalelo kanye neziphakamiso udokotela ukuba khona. Ngemithamo emincane noma emikhulu kungenzeka ingaphumeleli noma ungakulimaza impilo lesiguli.

Amaphilisi Abonayo "Itraconazole" analogue ezishibhile noma ezibizayo zithathwa kanje: Amaphilisi kanye amaphilisi zigwinywa lonke. Ngesikhathi esifanayo akufanele ukuhlafuna noma akuqede. Ngokunciphisa ezingeni asidi esiswini, kubangelwa, isibonelo,-cystic fibrosis, kubikwe kudokotela wakho kufanele.

Kwezinye izimo, le mishanguzo zomuthi angase ashintshwe. Ngokuvamile lokhu kwenzeka uma, phakathi ukwelashwa isiguli imithi ezilandelayo: "famotidine", "nizatidine", "esomeprazole", "cimetidine", "omeprazole", "Ranitidine", "Lansoprazole", "pantoprazole", " rabeprazole. "

Izimo

Kwezinye izimo, iziguli contraindicated "Itraconazole". Qondisa izidakamizwa ezifanayo ngokuvamile unqabela izidakamizwa ezifana antifungal for yokungezwani komzimba ukuze izingxenye zawo. Yingakho ukuqokwa yokwelapha nalezi izidakamizwa udokotela kufanele bazi kahle ukuthi isiguli ine ukusabela iguliswa into kufakwe Ukwakheka kwabo.

Imithi akufanele sithathwe kwabesifazane abakhulelwe noma lactating. Ukuvimbela ukukhulelwa kungenzeka ngesikhatsi ukwelashwa kubalulekile ukusebenzisa izindlela eziphumelelayo inzalo. Ngokunakekela izidakamizwa esebenzayo zaphathwa ezigulini esezikhulile. Ukuthola esengumntwana engavumelekile itholakala kuphela uma inzuzo bulingana naphezu kwengozi engase ivele. Umuthi is hhayi Kunconywa for iziguli ukumelwa inhliziyo, ischemia, ezinzima wamaphaphu nesifo, esingamahlalakhona kwezinso.

"Itraconazole" analogue zomuthi akufanele bathathe e umthamo double, ukudlula okungenzeka imithi. Kungcono bayakhohlwa umthamo aphuthelwe bese ulandela lwemithi. Asikwazi ukuvumela ukweqisa izidakamizwa zomuthi, noma analogue yayo, njengoba lokhu kungaholela izinkinga zempilo ezingathí sina kakhulu.

Ukuxhumana nezinye izidakamizwa

Ngaphambi kokuthatha "itraconazole" udokotela kufanele ukuqaphela ukuthi imithi isiguli kuthatha ngaphambili. Ikakhulukazi kumayelana ukusetshenziswa kwezidakamizwa ezifana "I-Efavirenz", "Everolimus", "Sildenafil", "Aliskiren", "Rifabutin", "apixaban", "NVP", "Dasatinib", "Ibrutinib", "Salmeterol", " darifenacin, "" Nilotinib "," Karbazepin "," Sunitinib "," Colchicine "," Rivaroxaban "," Phenobarbital "" Tamsulosin "," i-Isoniazid "," Phenytoin "" Vardenafil "," rifampicin "," NVP " "Temsirolimus".

Ngaphezu mikhiqizo ngaphambi kokusebenzisa "itraconazole" kufanele batshele udokotela wakho mayelana nokuthatha izinyathelo ezilandelayo:

• anticoagulants;

• imithi elwa namagciwane;

• protease inhibitors HIV;

• Amavithamini;

• Izithako zokudla (Izithako zokudla).

Nge kanyekanye ukusetshenziswa "itraconazole" futhi antacids asetshenziselwa zokugcina 1 ihora ngaphambi noma ngemuva kwamahora ambalwa ngemuva nokuphathwa imithi antifungal.

side effects

Izidakamizwa "Itraconazole" ngezinye izikhathi kubangela isiyezi kanye angaboni kahle ngesimo isithombe okuhlukene. Lapho ethola izidakamizwa abakwazi ukushayela imoto, futhi usebenze nge zikagesi ezahlukene. I izigameko ezingezinhle ezavela evamise kubika uma nithatha zihlanganisa ukuvuvukala, ukubuyisa, ukukhishwa isisu, ukuqunjelwa, isilungulela, elivela kuzo ukunambitheka ezingemnandi emlonyeni; anda ukujuluka, isiyezi, ubuhlungu bekhanda, ukopha izinsini sore, ubuhlungu bemisipha, kwehle imisipha ithoni, amakhala yisisu, imfiva, ubuhlungu bamalunga, ukucindezeleka, kwehle libido, iqothukile.

Yingozi ikakhulukazi impilo isiguli yilezi ezilandelayo imiphumela emibi: umbono double, isicanucanu, ukuhlanza, amajaqamba esiswini, ukuhluleka kwenhliziyo, isifo sokusha kwesibindi, incontinence urinary, anaphylactic nokungezwani komzimba nezinto, umchamo onombala, enkeneneza ezindlebeni, ukulahlekelwa kukuzwa, ukungakuthandi ukudla, ukukhathala ngokweqile , yellowing kwesikhumba namehlo, ukuba ndikindiki nokushoshozela isikhumba nezicubu elithambile, photophobia, ukuqubuka kwesikhumba, ukulunywa, hoarseness, edema yamaphaphu, iziyaluyalu kokuya esikhathini, ukuvuvukala ebusweni, nomphimbo, izandla, emaqakaleni. Uma uhlangabezana nanoma iziphi izimpawu ngenhla, lokhu kufanele kubikwe ngokushesha nodokotela wakho.

Indlela Khetha Analogue "itraconazole"

Minyaka yonke abantu abaningi babhekene nenkinga izifo fungal. Nokho, iziguli eziningi ukuthi liyini sibaphathe akusho ukuthi ukuthola "Itraconazole". Analogs eshibhile, ngakho avame ayethanda. Eqinisweni, umbuzo kukhethwa izidakamizwa noma analogue yayo kufanele juqula yodwa udokotela ukuba khona. Kwezinye izimo ezinzima, ekululameni kwesiguli egcwele kusiza sifinyelele kakhulu "Itraconazole". Analogs ezishibhile, kodwa hhayi bonke bangabafundi kahle njengoba izidakamizwa.

Kungashiwo okufanayo sathathelwa indawo 'Itraconazole "? Wamafutha, analogs ithuluzi kwezinye izinhlobo Isikali ivezwa Pharmacy kahle. I analogs kwesakhiwo zihlanganisa izidakamizwa ekhiqizwa amaphilisi okuphakelayo "Irunine", "Intramikol", "Itrazol", "Mikonihol", "Kanditral", "Kanazol", "Teknazol", "Orungal", "Rumikoz", "Orungamin "," orun ".

Analogs "itraconazole" ngoba isenzo imithi imikhiqizo ezilandelayo:

• Amaphilisi Abonayo "Diflucan", "Diflazon", "Itrazol", "Orungal", "Rumikoz", "Flucostat" "i-fluconazole", "Fungolon";
• amaphilisi "Atifin", "Binafin", "Ketoconazole", "Fungoterbin", "Ekzifin", "Nizoral";
• yokugcoba, okhilimu, si, "Akriderm" "Lamisil Dermagel", "Terbizil", "Ekzifin", "mikomaks", "Mikozoral", "Triderm", "Fungoterbin", "Ketoconazole", "Canison", "Lamitel" "Ngobuqotho", "Amiklon", "Zalain", "Canison", "Atifin", "Clotrimazole" "Lamisil" "Ifenek", "Lamitel", "Terbiks", "imide";
• suppositories, amaphilisi sangasese somuntu wesifazane, "Zalain", "Candide", "Canison", "Mikogal", "imide".

Izibuyekezo

Uyini umbono wakho kubantu ngokuthatha izidakamizwa "Itraconazole"? Analogue, okuyinto Izibuyekezo ngokuvamile ngomqondo ongathandeki, futhi lapho lokhu izidakamizwa ngokuvamile Ungasingenisi imiphumela kulindeleke kusukela yokwelapha. Kulokhu, inani elikhulu contraindications side effects ukwenza lezi izidakamizwa ngempela yingozi empilweni iziguli eziningi. Ngaphezu kwalokho, ingozi nemiphumela ebuhlungu ukusetshenziswa "itraconazole" futhi analogue yayo kakhulu anda-non-ukuhambisana imiyalelo udokotela noma ukuzilimaza medicate.

Isikhathi esining impela zikhona Izibuyekezo ezingezinhle mayelana izidakamizwa "Itraconazole" (amakhandlela). Analogs yalesi izidakamizwa futhi ivame ziqondakala iziguli ngokuqapha. Lokhu kungenxa yokuthi kwezinye izimo i-ekwelapheni izifo fungal ngosizo amakhandlela kumele kuzosungulwa ngokuthatha "itraconazole" noma analogs ngaphakathi.