Isimila umaka CA-125

CA 125 kubhekwa eliphezulu yamangqamuzana isisindo glycoprotein, kuyinto antigen. Senzeka derviatov kusukela epithelium coelomic izicubu fetus elikhona izicubu evamile endometrial, mucinous futhi serous umama yotshwala. Ukugeleza kwegazi akuwenzi ukungena, ngaphandle kwalapho kunezimo nolokubhujiswa izithiyo zemvelo.

I lokuhlushwa serum kungenziwa kabili esikhathini, e endometriosis ethile. Isimila umaka CA 125 kungenziwa kwaphakanyiswa senyanga yokuqala sokukhulelwa. A ukwanda kancane abesifazane enempilo ngenxa zamagama alo ku pleural, ingaphakathi peritoneal, epithelium bronchial, le pericardium, amashubhu fallopian; wesilisa - zamagama e-epithelium we testes.

Specific isimila umaka CA-125 kungathola isimila Ukudlulela ezinyangeni eziyisithupha ngaphambi ukuqala ukubonakaliswa emitholampilo (ukubonakaliswa). Leli qiniso kwenza kube nokwenzeka ukuhlola nomphumela oqabulayo ekwelapheni isifo.

Isimila umaka CA-125 kubaluleke kakhulu kule komdlavuza wesibeletho. I Assay kusekelwe ukuthola lokuhlala isigqugquzeli antigen egazini. Lezi ethize izinto ubufakazi yentuthuko lwesimila. antigen Abanye hormone, ama-enzyme, imfucumfucu nezinye neoplasms.

Ukuhlaziya isimila nakomaka ethize CA 125

Norm - amayunithi 35 / ml. Ukwanda ezingeni athethelelwe (kuyadamba) kubhekwa isisekelo inhlolovo isiguli kangcono ukukhomba ukuphinda isifo. Okuqhubekayo ukwanda amanani kubonisa Yiqiniso okuqhubekayo inqubo isimila, futhi ekhiqizwa ukusabela ekwelashweni.

Ukuhlaziya isimila umaka CA 125 has a ngokucacile ongaphakeme. Ngokuhambisana idatha izibalo ukwanda ekabili level yayo kule serum igazi, ikakhulukazi iziguli esezikhulile kuka neminyaka emashumi mahlanu anamihlanu, has a inkomba onokwethenjelwa emdlavuzeni wesibeletho.

Phakathi ukuyiswa amasampula futhi ukusetshenziswa zokugcina ukudla kufanele kube (mhlawumbe, yebo, ukuthi okungenani nambili) okungenani amahora ayisishiyagalombili. Anikwazi ukuphuza itiye, ujusi noma ikhofi. Imvume yokusebenzisa amanzi.

Izinga ekhulile yemiphumela antigen e serum kubonisa umdlavuza:

- e kwamanyikwe, indlala mammary;

- amaqanda, endometrium, kwesibeletho, amashubhu fallopian ;

- isibindi, esiswini, ingemuva;

- ukukhanya;

- ezinye komdlavuza.

A nokwanda okuphawulekayo ukusebenza ukubonwa ngemihlume ku wokugaya ukudla pheshana, webele futhi bronchi. Ngakho-ke, ukuxilonga ngokunembile umdlavuza esekelwe ukuhlaziya kuphela CA 125 akunakwenzeka. Ngenxa yalokhu, kubalulekile ukuba siqhube izifundo ezengeziwe.

A ukwanda kancane CA 125 kungavuka ingozi izifo zabesifazane umdlavuza uhlamvu, futhi izinqubo ukuvuvukala ezihilela izinto ezihlobene. Ukuze izifo kanye nezimo ezihlobene nokwanda kwentshiseko ezincane ezingeni antigen zihlanganisa:

- simila wesibeletho;

- i-endometriosis;

- ukuvuvukala izinto ezihlobene;

- pleurisy, peritonitis;

- STD;

- ukuya esikhathini;

- ngokoma kwesibindi, ukusha kwesibindi kohlobo ezingamahlalakhona;

- pancreatitis ezingamahlalakhona;

- ezinye izifo sokuhlasela kwamasosha omzimba.

Nge ukuthuthukiswa izimila benign nezinqubo ukuvuvukala, isimila umaka CA 125 akazidluli 100 U / ml. Ukuqaphelwa ngaleyo ndlela ebalulekile ekuhloleni kusebenta oqabulayo ukwelashwa esetshenziswa, futhi ukuthola preclinical ukuphinda ka endometriosis.

CA 125 kubhekwa oncomarker carcinoma serous e esibelethweni. Inkomba yayo amayunithi 150-200 / ml kubonisa ukuhileleka zokugula we ulwelwesi serous. Kulesi ezibalulekile ukuqapha lokuhlushwa yayo sokuhlola ukusebenza lokuhlinzwa, ngelashwa nangemithi. Endabeni inkomba in the hysterectomy igazi sehliselwe amayunithi eziyishumi ngemililitha ngayinye. Ukwandiswa kuya 35 U / ml kubonisa inqubo kokushelela.