'Arimidex' - yokusetshenziswa futhi impendulo

Umdlavuza webele yisona esikhulunywa abantu abaningi we sebuningini izinhlobo izimila anomdlavuza engxenyeni zesifazane lesintu. Njengomthetho, lesi sifo sitholakale umuntu oyedwa kwabesifazane ayisishiyagalombili ezingaphansi kweminyaka engu-minyaka engamashumi amane nanhlanu, futhi zonke nantathu - eneminyaka engu amahlanu nanhlanu.

Ukwelashwa nzima yokuthi umdlavuza sandile wonke umzimba ngohlelo lymph ngu kumiswa Ukudlulela. Ekuboneni isifo ngesikhathi ngaphambi kosuku kwenzeke ukwelashwa omuhle ukuze athethelelwe.

Kodwa futhi kwenzeka ukuthi emva ukudlula izifundo eziningana, ngelashwa nangemithi, ukusetshenziswa nokunwetshiwe imithi concomitant wukuthi ukuphathwa ukhethwa ngendlela efanele. Uhlobo ngalunye umdlavuza inezidingo zokwelapha yayo, kuye ngokuthi yobudala, kanye ukuqhubekela phambili kwesifo.

Ukuze sithole indlela yokwelapha yenziwa ukuhlolwa, main okuyinto Cytology. Kungaleso sikhathi kuphela lapho kungenzeka uthole ukwelashwa okufanele. Enye yezinkinga eziyinhloko enkulu ekukhethweni kuka izidakamizwa kungenzeka amathuba okuba nemiphumela engemihle ku insikazi esithweni, amehlo, isibindi kanye nezinso, kanye bone izicubu.

Ukuthola zomdlavuza ama-hormone engaphansi kuholela ekwelapheni i-hormone abamelene, enye yazo 'Arimidex'.

izidakamizwa okusebenzayo

A emashumini ambalwa eminyaka edlule, neziguli ezifakelwe ukuqokwa, waya ekhemisi futhi uthenge noma iyale umhlaziyi ayefisa izidakamizwa. Ngokungangabazeki noma wokuzisola wayiswa ukuze bayothola ukwelashwa. Esikhathini sethu, isiguli ifuna ukwazi ukuthi siyophuza? Yini kuphakama izinkinga zempilo ezengeziwe?

Ukuze ususe konke ukuphikisa, kumelwe ufunde imiyalelo 'Arimidex' umakhi. Isithako asebenzayo zomuthi - anastrozole. Kuyinto ejenti antineoplastic Lokudabuka zamakhemikhali, ivimbela kukhiqizwe aromatase enzyme.

Aromatase - ikhemikhali ithatha ingxenye ukwedlulela hormone ocansini besilisa (androgens) e abesifazane (estrogen). Inani anda estrogen ikhuthaza ukukhula estrogen izimila nasekuthengeni.

Yokuvimbela ekushayweni estrogen futhi anastrozole elisetshenziswa umthamo oqabulayo 1 mg ngosuku. Ukuthatha izidakamizwa ngokuqhubekayo, isiguli ngosuku lokuqala inciphise hormone egazini u-70%, kanye eminye 84%.

isicelo

Uma isiguli okwethembayo udokotela yakhe, uyokwelula ngokungenamibandela ukulandela yonke imiyalelo futhi izabelo. Ngisho ngabe zingekho njalo ilungile. Ngamakhemikhali iningi lezakhamuzi - kuyinto umthelela izakhi enemisebe ku amaseli pathogenic. Nokho, ukungenisa imithi, ezicindezelayo ukukhula kwabo ifomu tablet - futhi ngelashwa nangemithi.

Iziqondiso amaphilisi 'Arimidex' kuboniswa ngokucacile ukuthi ingasetshenziswa kuphela ekwelapheni abavamile (ezivamile) ka nomdlavuza wamabele kwabesifazane postmenopausal. Iphinde isetshenziselwe njengoba umkhiqizo indawo ladies labetibambile yokwelapha "tamoxifen" okungenani iminyaka emithathu.

Ngaphezu kwalokho, ezigulini eziye zabhekana kusaqalwa umdlavuza, ngokulandela imiyalelo ngokucacile, ukubuyekezwa 'Arimidex' uthola omuhle kuphela.

Isikali

Ukuze ukudluliswa lula amathuba okuba nemiphumela engemihle yalesi izidakamizwa ethile kufanele bacabangisise indlela nabaphathi bawo. Anastrazole ngezilinganiso elincane 1 mg imbangela engakwazi ezinzima komzimba, kanye zilulaza ukusebenza kwezinye izinhlaka bese izinhlelo.

Ukwelapha kulula ukugaya, ukuthatha iphilisi, wageza phansi ngokuba namanzi amaningi. engayitholi nsuku kumele kwenzeke ngesikhathi esifanayo ukuthi igazi lokuhlala zomuthi kayiwanga.

Izidakamizwa ukuthi kuyabekwa bangabonwa zamangqamuzana omdlavuza, njengoba umthetho, baphuze neminyaka emibili kuya kwemihlanu. Udokotela ukuba khona kufanele asayine esimisweni izivivinyo azosiza ukuze kuqashwe impilo jikelele isiguli kanye nomdlavuza.

Izici

Olwenziwe eminyakeni emibili, izifundo laboratory luye lwabonisa ukuthi anastrozole liyingxenye 'Arimidex' ingasetshenziswa kuphela kwabesifazane postmenopausal. Lokhu kungenxa yokuthi ukusetshenziswa eside kungabangela inkinga yokungabi nenzalo.

Izilwane asetshenziswe ucwaningo babonakala preimplantation Iqanda ukulahlekelwa futhi ukunciphisa isibalo sokukhulelwa ephephile. Nzalo azalelwa abanokukhubazeka okuhlukahlukene.

Ukuze ugweme imibuzo ehlukahlukene mayelana nemiphumela engemihle, yonke imiphumela senziwe "Arimidex". Zonke imiphumela emibi kwezinye izindawo sezihlonziwe ne nokwanda okuphawulekayo ngemithamo nsuku zonke i-reception (25 kuya ku-50 mg).

side effects

Esikhathini yokusetshenziswa "Armideksa" ubala zonke kwezinso kungenzeka babonakala e amavolontiya zesifazane ngesikhatsi ukwelashwa. Ngo abantu abangaba yizinkulungwane ezingamashumi ayisihlanu wathatha ukuhlanganyela esifundweni, eziningi zazo ziye zaphathwa ngempumelelo.

• Kwakukhona ukwephula isimiso sezinzwa ngesimo ukukhathazeka, ukucindezeleka, ukozela noma ukuqwasha, ukushintshashintsha kwemizwelo, amehlo ubuthakathaka jikelele.
• Isimiso senhliziyo nemithambo yegazi: high blood pressure, isiyezi, ubuhlungu bekhanda obunzima, thrombosis, thrombophlebitis, leukopenia, edema ka inhliziyo izicubu hlobo.
• uhlelo zokuphefumula: umoya eliyifa, izifo sokuvuvukala ephashini, ikhala nomphimbo (ukucinana kwemigudu yokuphefumula, tracheobronchitis, laryngitis, rhinosinusitis, pharyngitis).
• GI: isicanucanu, ukuhlanza, kahle wamathumbu umsebenzi (ukuqunjelwa, uhudo), nomlomo owomile, sinombono nezinkinga amathumbu kungaba anorexia noma ngokudla nge iqoqo isisindo esengeziwe.
• Zabesifazane: ukoma futhi ukulunywa ka nolwelwesi lwamafinyila, iziyaluyalu zokuzala, lesizalo ukopha kubangelwa ushintsho zomuthi.
• System zemisipha: thinning kungenzeka ithambo izicubu ngenxa yokusebenzisana isikhathi eside, ngokuthwebula iminwe syndrome.

analogs

Emaketangeni ekhemisi akulula ukuthola izidakamizwa eqondile. Kulabo abaye ufunde ngokucophelela yokusetshenziswa 'Arimidex', analogs, zingaphansi kwakhe emalini, kuba lula kakhulu ukuthola. Nakuba ukhuluma ngani ngentengo ephansi kakhulu akanayo, ngoba abantu abamelene nani ama-hormone, kodwa namanje producer okuhle, uhlale ngempela eqolo.

analogs Okugcwele ye-ejenti asebenzayo kufanele zimumethe anastrozole ngezilinganiso 1 mg. Kulendzawo yangaphambilini CIS amazwe ezifana kukhona ezimbalwa, kodwa ukhiqizwa emazweni ahlukene, avame kuba aseBaltic. Nakuba zikhona izidakamizwa ezikhiqiza e-India, Russia nase-Ukraine.

"Aksastrol"

Umuthi ukhiqiza ezithaka imithi ifektri "Grindeks", Latvia. Ngo emaphaketheni ifilimu amaphilisi amabili nesishiyagalombili camera ngamunye equkethe 1 mg anastrozole.

Ubufakazi bubonisa ukuthi bangakwazi aphathwe eziphambili nomdlavuza wamabele kwabesifazane postmenopausal.

Of Izimo - nokukhulelwa kanye lactation, kanye ukuzwela umuntu ukuba Anastrozole.

Intengo yaleli izidakamizwa i-Russian silinganiselwa ruble ayizigidi 5-8, futhi e-Ukraine - kusuka 1500 kuya ku-1800 izinkulungwane UAH.

"Anastera"

Ukulungiswa iqukethe 1 mg anastrozole, kodwa kukhiqizwa e-Argentina. Kunezinhlobo ezimbili zama-emaphaketheni: owokuqala - amabhamuza ezimbili amaphilisi nane ngalinye; yesibili - ezintathu amabhamuza amaphilisi eyishumi emunye.

iqembu kwemithi ichazwa njengesifo omelene ne-hormone okuthiwa i-inhibitor enzyme.

I izinkomba efakwe ngaphezu uhlobo ukwelashwa estrogenpozitivnogo yomdlavuza kubantu besifazane postmenopausal ithuba ukusebenzisa in iziguli uhlobo estrogenotritsatelnym, kodwa umuzwa omuhle ukwelashwa "Tamoxifen" owayethe.

"Anastrozole Sandoz"

Ikhishwa eJalimane inkampani eyenza imithi "Sandoz". I intshabusuku iphakethe, izibhebhe ezimbili amabili nesishiyagalombili. Isikali indlela yokuthola ngokuphelele kuhambisane imfundo 'Arimidex'.

I contra-wabonisa, ukhulelwe, ibele kanye nezingane.

Lokho okwakudingeka ukuze kukhokhwe izidakamizwa kakhulu ngaphansana original. Uphinde ibekezelelwe kahle, kodwa ibekhona ukuze ithengwe.

Izimo

Njengoba kushiwo ngenhla, ngokuvumelana 'Arimidex' imiyalelo ayikwazi esetshenziswa abesifazane phakathi nokukhulelwa kanye lactation.

Enye yezinto ezithinta ikhono ukusebenzisa izidakamizwa, kuba tolerability ngabanye. Asenesikhathi luvelo Anastrozole, nokuhlala e primenopauze yokusebenzisa "Tamoxifen" noma i-estrogen izidakamizwa 'Arimidex' ingasetshenziswa yini.

Ngokunakekela, noma ingasetshenziswa ngokukhetha kubantu abaphethwe kwamathambo, encishisiwe lipid ibhalansi, isifo senhliziyo.

Abesifazane abaphethwe kwamathambo, ukuthambekela ukuthambisa bone fragility e nomkhiqizi imiyalo 'Arimidex' washo ngokucacile ukuthi ukusetshenziswa kungenzeka, kodwa ngokuqapha okukhulu. Kuyadingeka ukuba ihlolwe ukuqinisekisa kwamathambo, kanye oyifunayo ezengeziwe calcium zinsiza nge kavithamini D. Ezimweni ekhethekile, uma kukhona awokuthi ukwehla kwabantu kungase esasikhipha bisphosphonates ku usaqala umdlavuza phambi ukwabela 'Arimidex'.

nezinye izindawo

abayithandayo Omkhulu hormone kukhona izinhlobo ezahlukene abasubathi. Lokhu professional abasubathi sawo esiningi futhi Powerlifting. Ngaphambi mncintiswano bephumelela inkambo olukhethekile Ama-anabolic steroid, siyivumele ukuba bathole ukuma elilungile ngokomzimba.

Uma ukhumbule ekusetshenzisweni imiyalo 'Arimidex', analogue yayo esetshenziswa ukucindezela hormone zesifazane ezihilelekile ekwakhekeni ubulili eyinhloko izici. Phakathi kwama-steroid yokwelapha abasubathi nazo evuvukele nezindlala mammary, soreness, ububomvu.

Ngaphezu ezikhethekile izimpahla abasubathi ngokuvamile zisebenzisa analogue 'Arimidex', ngokulandela imiyalelo of umthamo kanye nobude ukusetshenziswa.

Ukuze ugweme zonke "izintelezi" yokwelapha akhethiwe, abasubathi uqale ukuphuza Anastrazole ngosuku lweshumi kusukela ekuqaleni Yiqiniso bystrovyvodimymi steroid. Nakuba le ndlela akuyona panacea futhi kufanele kwenziwe ngaphansi kweso lwezokwelapha esiqinile.

Izibuyekezo

izidakamizwa kwama-hormone - eziningi ukucindezeleka emzimbeni. Ithinta zonke izinhlaka kanye nezinhlelo, kanye umzimba awutholi izinto ezidingekayo, ukuzama ukuze sivale lapho sisilela ngezindlela ezahlukene.

Imibono ka kodokotela neziguli ebhekene 'Arimidex' izidakamizwa, kunalokho edidayo. Inani elikhulu leziguli wathola ukuqashwa kukaNksz "Arimidex 'ngemva kwenye omelene yokwelapha i-estrogen -" tamoxifen ".

Endaweni yokuqala zibiza zomuthi uyalandelwa. Ukwenza aphoyintimenti, ochwepheshe abaningi basikisela ufunde imiyalelo ukusetshenziswa 'Arimidex', analogs nokubuyekeza usefake isicelo abantu bakhe. Kungani-ke ngakho ngemibuzo?

yokungenisa Izidakamizwa umakhi, ngoba abathile abanomdlavuza, ikhishwe mahhala. Ukuze uthole it, udinga ama-ruble ayizigidi eziyisishiyagalombili ngenyanga. Akuwona wonke nesineke ungakwazi yini ukusikhokhela.

Kodwa Izibuyekezo iziguli opt nje esebenzayo izidakamizwa anastrozole, ubuhle bodwa kuyo. Uthwala lula kakhulu ukwedlula "Tamoxifen". Ngaphansi enobuthi emzimbeni, futhi okubaluleke kakhulu, ayikhiphi enjalo engemihle.

Ezinyangeni zokuqala of the reception, kuye ngokuthi umuntu ukubekezelelana 'Arimidex' anganika ukucanuzela kwenhliziyo, ukuhlanza kanye ubuthakathaka jikelele. Labo nalo lwenzeka ngesikhathi ngamakhemikhali ayikwazanga ukusho ngokuqiniseka ukuthi sanikwa lokhu isimo.

Ngokuvamile, ukuphuza amaphilisi kuyinto okuvamile. Iziguli wazama ukuthenga ezifuywayo bese ugcine ukulungiselela ngempahla asebenzayo esifanayo, unganelisekile. Wawubekezelela a diki ngcolile, futhi okubaluleke kakhulu, lesibonakaliso sokuqala kwaba nobuhlungu obukhulu emalungeni.

Umuthi yokuzikhethela?

Kunenkinga enkulu nge ekutholeni ukwelashwa mahhala abesifazane babona kutholakala ukuthi uphethwe yini - "umdlavuza webele". Ezidakamizweni iziguli Oncology Centre ungakwazi kuphela ancike "Tamoxifen", kodwa abakhiqizi yasekhaya.

Lokhu ukulungiselela wenziwa kanzima, nakuba imiphumela unika ezinhle. Ngenxa nokubuyekezwa ukusetshenziswa imiyalo 'Arimidex', analogue yayo, ungakwazi ukukhetha ukuthi iziphi izidakamizwa kufanele zamukelwe.

Odokotela bathi isikhathi esingcono ukwelashwa "Arimidex" - esibhalisiwe isikhathi esiyiminyaka emithathu noma emine ngemuva kokuqala ukwelashwa "tamoxifen". Kakhulu akuvamile, kungabonwa njengoba kulungiselelwa yokwelapha kokuqala.

Khomba abesifazane ukuba anastrozole izinkomba zezempilo, kuyilapho ezinye, ama-enzyme nolaka abamelene isiguli singenakukwazi ukuthuthela. Kodwa ngabo kuyinto umbuzo evulekile ukutholakala kwezidakamizwa obakhathalelayo. izidakamizwa Packaging nibaluleke ukudlula elamukelayo impesheni. A amaphilisi iphakethe esikhundleni amathathu ngalinye amabili nesishiyagalombili ngoba ngonyaka tente izindleko ezengeziwe.

Ukuze anqume ekuthatheni lesi imithi, kufanele uqinisekise ukuthi ufunda incazelo 'Arimidex' e imiyalelo kanye nokubuyekeza bese sivele sidlulile inkambo iziguli. Mhlawumbe bangakwazi ukusiza nge isinqumo: ukuthatha noma cha. Nakuba ukukhuluma ngezidakamizwa esetshenziswa abantu ababulawa umdlavuza wamabele njengoba izidakamizwa oluthandwa akulungile.

Ngamunye wabesifazane wezwa uphethwe esabekayo, silwela ukuphila kwakhe futhi impilo kuze kube sekugcineni, usebenzisa zonke izindlela.