Analogs, yokusetshenziswa "Naropin". Izibuyekezo ikhasimende

Zokubulala izinzwa okuthiwa nezidakamizwa unekhono ntombazane izinzwa.

Anesthesia - ukwehla nozwela umzimba noma izingxenye zayo. Futhi, ngoba isimo esinjalo elinesimo ukumisa okuphelele bezibona ulwazi mayelana nesimo umzimba kanye nemvelo.

Zokwelapha, ukuze kubulawe izinzwa livame ukusetshenziswa kwezidakamizwa "Naropin." Yokusetshenziswa, ochwepheshe zangempela uzobe kuchaziwe ngezansi.

Ukwakheka, Ukwakheka kanye Okufakiwe

Ukulungiselela "Naropin" imfundo okuyinto eziqukethwe isixha amakhadibhodi kukhishelwa ngesimo ikhambi nemijovo. Lungase luhlanganise 2, 5, 7.5 noma 10 mg isithako esebenzayo njengoba ropivacaine hydrochloride.

Ngokuphathelene izingxenye ezengeziwe, bese uwasebenzisa njengoba hydrochloric acid noma sodium hydroxide, namanzi umjovo kanye sodium chloride.

Ngo ukudayiswa lesi sakhiwo ihlinzekwa in vials.

Izimfanelo kwemithi zomuthi

Kuyini lokhu imithi ngokuthi "Naropin"? Iziyalezo yokusetshenziswa uthi lokhu amide uchungechunge izinzwa, okuyinto yakhelwe ukukhululeka ubuhlungu futhi izinzwa wendawo.

Ukusetshenziswa kwafakwa isilinganiso esincane semithi ukuvinjelwa ropivacaine kusiza ngokukhethekile somzimba ngozwelo encishisiwe-non-okuqhubekayo motor umsebenzi.

Ngo imithamo ephezulu zomuthi kuholela izinzwa lapho kuhlinzwa.

izakhiwo zomuthi

Kuyini izidakamizwa emangalisayo "Naropin"? Yokusetshenziswa ubonisa ukuthi ukusebenza kwaleli thuluzi kungenxa ikhono layo reversibly ukunciphisa permeability we Ulwelwesi lwamangqamuzana yezinzwa. Ngenxa leli thonya, futhi kukhulisa excitability embundwini depolarization izinga liyancipha, okuyinto ke kuholela wendawo Ukuvinjwa emsipheni amaza.

Lapho usebenzisa i-ngemithamo ephakeme liphawuleka umphumela wawo inhibitory enhliziyweni futhi CNS (conductivity eziwohlokayo incipha automatism futhi excitability).

Ukuze ropivacaine isici nomphumela owaqhubeka isikhathi eside. Isikhathi umphumela oqabulayo umthamo izidakamizwa kungase kushintshwe.

Lapho ekuphathweni epidural isidakamizwa kuyinto okhombisa ezimbili zayo kanye ukumuncwa ephelele evela emkhathini epidural. I lokuhlushwa ropivacaine egazini lincike indlela isicelo.

I kinetics kwezidakamizwa

Yokusetshenziswa ( "Naropin" kufanele sinikezwe kuphela nodokotela obulala izinzwa abanolwazi) ibika ukuthi ithuluzi has pharmacokinetics komugqa. Ngenxa yalokhu, lokuhlushwa wobuningi egazini wakhona umthamo iqondiswa.

Ukuxhumana-plasma amaprotheni 94%.

ekuphathweni Epidural we nomuthi isikhathi eside kwandisa inani plasma lokuhlushwa ropivacaine.

Ingqikithi asebenzayo kubhekwa indlela asitholayo okusheshayo ukuguqulwa umzimba. Esigabeni sokuqala isigamu-nokuphila isikhathi ilingana ¼ ihora, futhi ukuphela - 240 amaminithi.

Lapho kulungiselelwa emthanjeni 86% we umthamo excreted ngu nezinso.

ubufakazi

Ngayiphi injongo usebenzise izidakamizwa ngokuthi "Naropin"? Yokusetshenziswa (amazinyo, lokhu izidakamizwa iqondiswa kakhulu njalo) uthi izidakamizwa senzelwe izinzwa phakathi nokuhlinzwa:

• Ukuze ukuvinjelwa nezinzwa ezinkulu futhi izinzwa plexus.
• Ukuze kokuziphatha izinzwa futhi izinzwa ukuvinjelwa ngabanye zesivikelo sesifuba.
• Ukuze ukuvinjelwa epidural ukuze baqhube imisebenzi, kuhlanganise nezigaba caesarean.

Kumele kuqashelwe futhi ukuthi lesi sidakamizwa "Naropin" ngokuvamile sisetshenziswa ngempumuzo izimpawu e-acute ubuhlungu syndromes:

• Ukuze ukuvinjelwa eside nezinzwa neuropathy.
• Ukuze naphakathi-articular umjovo.
• Ukuze kokuziphatha izinzwa futhi izinzwa ukuvinjelwa ngabanye zesivikelo sesifuba.
• Lapho kuqhubeka isikhathi eside ukumnika epidural, bolus PERIODICITY noma ubuhlungu ekuvimbeleni esikhathini postoperative, kanye izinzwa ngesikhathi sokubeletha.

Kufanele kuphawulwe ukuthi umuthi "Naropin" ukufundiswa ukusetshenziswa oboniswe ngezansi, limatasa esetshenziselwa ngempumuzo izimpawu ahlekise ezigulini ezingane:

• I-caudal block epidural ezinganeni ezingaphansi kweminyaka engu-12, kuhlanganise nesi-izinsana;
• ngoba isikhathi eside ukumnika epidural ezinganeni iminyaka engu-12, kuhlanganise nesi-izinsana.

Izimo

Yiziphi Izimo izinzwa is "Naropin"? Yokusetshenziswa (i izinzwa emgogodleni iyithuluzi kufanele sinikezwe kuphela izinzwa abanolwazi) ithi enqabelo ezilandelayo:

• Hypersensitivity, owabonakaliswa imithi yokubulala izinzwa yochungechunge amide (kuhlanganise umlando).
• Hypersensitivity ukuze ropivacaine nezinye izingxenye ekwakhiweni.

Kufanele kuqashelwe ukuthi le nomuthi "Naropin", umthamo Kufanele kukhethwe kuphela onguchwepheshe, sokuqapha ezigulini esezikhulile futhi ephelile, futhi iziguli nemvelo ezinzima zezifo, kuhlanganise intracardiac conduction ukuvinjelwa, isibindi nezinso egunjini lokuhlolwa kwezifo.

Kumelwe uqaphe kakhulu zaphathwa izinzwa zendawo ikhanda nentamo ngenxa kwengozi ukusabela kabi komzimba ezingezinhle.

Kudinga ukunakekelwa okukhethekile lapho ewanika naphakathi izidakamizwa, ikakhulukazi ukuhlukumezeka ezinkulu ukuhlinzwa. Uma kungenjalo, kungase kubangele ukumuncwa kakhudlwana izidakamizwa futhi ukwandisa plasma yayo okuhlushwa.

Ngenxa nokungathuthuki imisebenzi futhi izidumbu zabantwana izinyanga eziyisithupha ukuqhuba izinzwa kuleli qoqo leminyaka batholakale kufanele kwenziwe ngokucophelela okukhulu.

Umuthi "Naropin": yokusetshenziswa izingane

Amazwana ngalokhu imithi izokwethulwa ngezansi.

Lapho caudal ekuphathweni epidural ngempumuzo zobuhlungu syndromes izingane nesisindo 25 kg eyenziwa ukuvinjelwa komjovo nekhambi umthamo 2 mg / kg.

Epidural ukumnika noma bolus umjovo we izidakamizwa Kwenziwa ngokuhambisana yobudala kwengane:

• izinyanga 6-12: ukumnika - 0.4 mg / kg / ihora, a bolus - 1 mg / kg;
• kuze kufinyelele ezinyangeni eziyisithupha: ukumnika - 0.2 mg / kg / ihora, a bolus - 1 mg / kg.
• eminyakeni 1-12: ukumnika - 0.4 mg / kg / ihora, a bolus - 2 mg / kg.

Isixazululo "Naropin": yokusetshenziswa

I ampoules izinzwa okuthengiswa yonke Pharmacy.

Kubantu abadala, umthamo umuthi Uchwepheshe akhethiwe. Udokotela obulala izinzwa kufanele aqondiswe isipiliyoni sabo emitholampilo kanye acabangele isimo ngabanye isiguli.

Ukuze abaphathi epidural phakathi nokuhlinzwa usebenzisa 15-25 ml isixazululo. Ngakho lapho kuqala isinyathelo waphawula ngemva kwemizuzu engu-20 futhi kuthathe amahora 5.

Inani efanayo kokusetshenziswa kwezidakamizwa kanye nesigaba cesarean.

Ukuvinjelwa ezinkulu ezinzwa plexus eyenziwa abaphathi epidural ka nomuthi ezingeni thoracic e isamba 5-15 ml.

Conduction futhi kokuziphatha izinzwa ne 1-30 ml imiphumela isixazululo e ukuqala ukusebenza emva kwemizuzu 5-15 nge ubude amahora 2-6.

izincomo ezithile

Isikali "Naropin" kwezidakamizwa izinzwa emgogodleni is kushintshwe kuye ngokuthi isimo jikelele isiguli. Kuyefana nasendleleni nokuvinjelwa yezinzwa.

Anesthesia we plexus brachial kungenziwa ephelezelwa eyaba nemiphumela emibi.

Ngekusetjentiswa ngesikhathi esisodwa nezinye izinhlobo imithi yokubulala izinzwa umthamo esiphezulu "Naropin" Akufanele futhi iyophakama kuno-225 mg.

Ukuvimbela umjovo ngephutha izidakamizwa ku isitsha ngaphambi kokuqala inqubo ngesikhathi ke kufanele kube impoqo ukuba afeze isifiso test.

Ukwethulwa kwe isidakamizwa elibonakalayo yesikhashana intravascular njalo kwenhliziyo. Lapho waphawula umphumela ezinobuthi kufanele ngokushesha uphazamisa nokwethulwa kwesixazululo.

Phakathi izinzwa kuyadingeka ukuqapha operation evamile izitho ezibalulekile kanye nezinhlelo isiguli. Kuyadingeka ukuba silondoloze ngayo athinte ngamazwi.

side effects

ukusabela ezingezinhle okuye kwaqashelwa isicelo kubhekwe kusho ezifana nalezo uma usebenzisa ezinye imithi yokubulala izinzwa amide chungechunge. Ngakho kubalulekile ukuhlukanisa imiphumela emibi ngezimpawu bokuphila ukuthi zenzeka ngenxa ukuvaleka nezinzwa nozwela.

Umuthi "Naropin" I-izinzwa emgogodleni kungadala bradycardia futhi hypotension. Futhi ngokuhamba izinzwa ezigulini sithola ukusabela elandelayo enqabayo:

• isicanucanu, tachycardia, ikhanda elibuhlungu, hypothermia;
• ukwehlisa umfutho wegazi, amajaqamba, ubuhlungu emuva, iphika;
• ukuhlanza, nakwisyncope, umfutho wegazi ophakeme, umkhuhlane;
• paresthesia, dysarthria, Ukugodola, ukukhathazeka;
• isiyezi, liqhaqhazela, nokugcinwa urinary.
• hypoesthesia, iphika, ukuba ndikindiki kolimi;
• ukuquleka, ukuluma, isifuba;
• paresthesia perioral endaweni, arrhythmia, angaboni kahle;
• Angioedema, ukuboshwa inhliziyo, imisipha amajaqamba;
• mkhuba anaphylactic.

analogs

Yini esikhundleni izinzwa ezifana "Naropin"? Yokusetshenziswa ngeke unike impendulo yalo mbuzo. Ngemuva ke uzodinga ukuxhumana ongudokotela obulala izinzwa abanolwazi.

Njengomthetho, esikhundleni "Naropin" ochwepheshe ngokuvamile zisebenzisa izidakamizwa njenge "Articaine", "Bupivacaine", "BlokkoS", "Alfakain SP", "lidocaine", "Brilokain-adrenaline", "mepivacaine," "Piromekain" "marcaine", "Skandonest", "Ultrakain", "Tsitokartin", "Trimekain", "Hirokain" nabanye.

Kufanele kube ngokushesha waqaphela ukuthi izindaba okwakudingeka izindlela zokuphatha kanye imithamo okukhulunywa izindlela ezingase ezihluke kakhulu kulezo we nomuthi "Naropin".

Izibuyekezo

Manje ngoba sewuyazi ukuthi kanjani futhi kungani ukusetshenziswa ezifana antibiotic "Naropin." Yokusetshenziswa, izidakamizwa analogs eziye sethulwa ngenhla.

Ngokuvamile kubhekwa indlela ukushiya ukubuyekezwa kwawo obulala izinzwa. Futhi lokhu akumangalisi, ngoba izidakamizwa senzelwe imisebenzi ezincane nezinkulu.

Iningi kwezimpendulo Ochwepheshe akhayo. Kufinyeta imibono odokotela, izinzwa lingachazwa ngokuthi a, imithi onokwethenjelwa futhi ngokulinganisela ezingabizi eside ziphumelela.

Njengoba for the iziguli, ukubuyekezwa kwawo salesi sibhedlela cishe ziphinde zenzeke.