"Levothyroxine": imfundo manual, ukubuyekezwa, izincazelo, analogs

Yini 'prescribers Levothyroxine "? Yokusetshenziswa, odokotela real mayelana leli thuluzi izokwethulwa ngezansi. Siphinde ngikuxoxele kwindlela umkhulula lo imithi, uma unazo contraindications imiphumela eminingi engemihle njengezindlela ke kungenziwa indawo, nokunye. D.

Ukwakheka izidakamizwa futhi injalo ukukhululwa

ungakwazi ukuthenga izidakamizwa "Levothyroxine" ngayiphi indlela? Yokusetshenziswa, odokotela Izibuyekezo bathi lo muthi itholakala amaphilisi. Ngo ukudayiswa zifika izamba ezilandelayo: 50, 25, 100,75, 150, 125, 200 noma 175 mcg. isithako yabo esebenzayo levothyroxine sodium.

amathuluzi kwebalingisi kwemithi

Kuyini idivayisi wezokwelapha "Levothyroxine"? Yokusetshenziswa, leli thuluzi Izibuyekezo aqukethe ulwazi mayelana lokuthi kuba hormone yegilo, okuyinto has a umsuka zokwenziwa.

Ngemithamo emincane izidakamizwa uyakwazi nethonya umphumela Anabolic (okungukuthi, ukugqugquzela ukukhiqizwa amaprotheni). Mean amavolumu nomuthi kwandisa umsebenzi we sezinzwa futhi senhliziyo izicubu uhlelo umoya-mpilo ngokufunwa, isebenze amaprotheni umzimba kanye amafutha kanye carbohydrate.

Ngokuphathelene ebulilini lapho izidakamizwa kusiza ukuphungula ukukhiqizwa kwama-hormone of pituitary futhi ngxenye ukuthi akhiqizwa endocrine nezindlala (ebuchosheni).

I pharmacokinetics komkhiqizo okwelapha

Lapho futhi isikhathi eside kangakanani lowo muthi amuncwa umzimba "Levothyroxine"? kusho ziqondiso zithi emva ukumuncwa ngomlomo izidakamizwa lisuselwa emathunjini futhi cishe 49-78%.

Ukuthatha imithi ngokuzila ukudla kakhulu kwandisa ukumuncwa isithako esebenzayo. Ubuningi umkhiqizo lokuhlushwa safinyelela ngemva cishe 5-6 amahora.

Ukuxhumana-plasma amaprotheni ngaphezu kuka 98%.

Distribution zomuthi senzeka ikakhulu esibindini futhi imisipha, kanye nobuchopho.

Ingxenye-ukuphila 1 iviki. Cishe 15% of the izidakamizwa excreted ne Bile futhi ngokusebenzisa izinso - ngesimo conjugates ngefomu unmodified, ngokulandelana.

Izinkomba ukusetshenziswa lomutsi

Yini engase imithi inikezwa "Levothyroxine"? Imiyalelo enamathiselwe le ndlela ikhombisa izinkomba ezilandelayo:

• goiter okuxubile;
• secondary hypothyroidism eyinhloko;
• Inhlanganisela Ukwelashwa of goiter anobuthi, thyroiditis sokuhlasela kwamasosha omzimba , futhi yegilo indlala Hyperplasia euthyroid;
• cretinism;
• zokuvimbela ukuphinda ngemva ukungenelela kuhlinzwa phezu yegilo (emva ukususwa izimila ebulalayo nodal).

Futhi sodium levothyroxine isetshenziselwa umehluko zokuxilonga test yegilo ukucindezelwa.

Izimo kokuthola

Awukwazi ukuthatha imithi "Levothyroxine" ngaphansi kwanoma iyiphi ngeziphambeko? Tablets ezibhekwa yithi, kwenqatshelwe ukuyisebenzisa nge -hyperthyroidism, isilethikusebenza (acute). Liphinde contraindicated nge hypersensitivity kuya impahla isizinda (ngamanye amazwi, levothyroxine sodium) is hhayi belashwa esingamahlalakhona adrenocortical.

Izidakamizwa "Levothyroxine": yokusetshenziswa

Izibuyekezo ngalokhu izidakamizwa eziqukethe ngayo ukwaziswa umphumela wawo ubonakala amahora kuphela ngemva 7-13 emva Ukuqalwa yokwelapha. Kodwa lena kuphela icala uma imithi umiswe wobufakazi e umthamo kwesokudla.

Umthamo we izidakamizwa kubhekwa ekwelapheni ukuphambuka Kumiswa umuntu ngamunye kuye ebufakazini obutholakalayo. Ngokuvamile ekuqaleni ukwelashwa nomuthi asebenzayo isetshenziswa umthamo 12.5-25 mg kanye ngelanga (imizuzu 25-30 ngaphambi kokudla). Nokho, njengendlela yokwelapha yesondlo, leli nani afinyelele 200 mcg ngosuku.

Ngesikhathi umehluko kweemboniso izidakamizwa iqondiswa singly e inani 3 mg noma izinsuku ezingu-14 e-200 UG kanye nsuku zonke.

Ukuze ekwelapheni azalwa naso hypothyroidism ubunjalo izingane ngaphansi kwezinyanga ezingu-6, nika 25-50 mg izimali kuze kube unyaka ongu-1 - 60 mg, futhi baphakathi kweminyaka engu-1 kuya eminyakeni emi-5 - 100 mcg. Izingane ezindadlana (iminyaka 6 kuya ku-12) sodium levothyroxine iqondiswa e umthamo 150 micrograms. Izingane Ezisathomba sebeneminyaka engu-12 kukhona 200 micrograms ngosuku.

Abadala nale uphethwe, njengoba i-hyperthyroidism, ukuncoma ukuthatha 25-100 mg zomuthi ngosuku. Uma lokhu umthamo liyakhula kancane kancane (njalo emavikini amabili noma amathathu, 25-50 g). Ngenxa yalokho, ivolumu sifinyelela nomuthi futhi izisekelo imayelana 125-250 micrograms ngosuku.

Ngemva ukususwa kuhlinzwa we ebulalayo isimila izidakamizwa ematfuba isamba 300 g.

Lapho goitre euthyroid, kanye ukuvimbela yayo kabusha kumiswa imithi enqunyiwe abadala e isamba 75-200 mg, nezingane - 12.5-150 micrograms ngosuku.

Imiphumela emibi ngemva kokwamukela nomuthi

Ngingakujabulela yini lesi sidakamizwa "Levothyroxine" kanye notshwala? Kuze kube manje, nokuxhumana ithuluzi nge utshwala hhayi kusungulwa. Nokho, ngesikhathi ngemithi hormone kungukuthi Kunconywa ukuba nokusebenzisa kabi uphuzo oludakayo.

Njengoba for side effects ngemuva kokuthola izidakamizwa kokubuyekezwa, iziguli ingase ibe nezimpawu ezithile ka-hyperthyroidism. Phakathi kwazo kunabafundi uthi ezilandelayo: palpitations, tachycardia, arrhythmia, ikhanda elibuhlungu, i-angina, liqhaqhazela, uvalo umuzwa ukungahlaliseki kwangaphakathi, ubuthongo thuthuva, amajaqamba, ukuncipha emzibeni, ukuba buthakathaka kwezicubu, uhudo, ukuhlanza, iziyaluyalu kokuya esikhathini.

Imishini yezokwelapha Overdose

Endabeni ka ukweqisa izidakamizwa nale izidakamizwa isiguli nezimpawu nobuntu hyperthyroidism ezinzima noma okusesilinganisweni. Therapy okunezimpawu isetshenziswa njengendlela yokwelapha izimo ezinjalo. Kulokhu, imithi ngokushesha amankeyane.

Kungenzeka futhi ukuthi anikeze i-beta-blocker. Lapho usebenzisa i-ngemithamo kakhulu plasmapheresis wenziwa. Asinakusho ukuthi kuleli cala, hemodialysis ayizwakali.

Ukuxhumana nezinye izidakamizwa

Ngingakujabulela yini lesi sidakamizwa "Levothyroxine" ne-calcium? Lo msuka, kanye aluminium hydroxide kanye sucralfate ukunciphisa absorbability we ketshezi esebenzayo ye nomuthi wokuqala kusukela pheshana emathunjini.

Kufanele kuqashelwe ukuthi le isici esiyinhloko zomuthi potentiates isenzo anticoagulants futhi kunciphisa ukusebenza kahle ejenti hypoglycemic (TEMLOMO).

Ngo iziguli sikashukela mellitus kanye hypothyroidism e ukwelashwa esikhundleni imithi hormone yegilo kungenteka kwenyuke isidingo amanxusa hypoglycemic (TEMLOMO) noma nge-insulini.

Bishydroxycoumarin, salicylates, clofibrate futhi furosemide ungakwazi ngempela kalula azixoshe levothyroxine sodium ka ebudlelwaneni bayo nalowo plasma amaprotheni.

Cholestyramine kunciphisa ukumuncwa izinto asebenzayo kusuka pheshana emathunjini.

Uma usebenzisa "ritonavir" babe awokuthi ukukhula kwesidingo "levothyroxine".

Phakathi isicelo "sertraline" kubantu ezine-hypothyroidism incipha umphumela levothyroxine sodium.

Nakuba yokuvuma "Chloroquine" kungenteka kwenyuke umzimba levothyroxine futhi TSH lokuhlala.

Ibele nokukhulelwa

Phakathi lactation futhi sokukhulelwa kubhekwe izidakamizwa kufanele asetshenziswe kuphela ngaphansi kokuqondisa kukadokotela sika. Sebenzisa ngokuhlanganyela tireostaticheskimi ejenti ngesikhathi sokukhulelwa is contraindicated. Lokhu sihlotshaniswa kwengozi hypothyroidism ku-fetus esibelethweni.

imiyalelo ezikhethekile ethola izidakamizwa

Kungani izidakamizwa "Levothyroxine" futhi nezinwele bahlobene? Iqiniso lokuthi kokunikezwa kwe-ndlala ndlala iziguli kungenzeka ngempela ukulahlekelwa izinwele zakhe. Nokho, lapho ethola lesi siboniso nomuthi ukungalingani hormone cishe iqedwe ngokuphelele.

Imoto kuncike ngokucophelela okukhulu elibekelwe nabantu isifo senhliziyo, kuhlanganise nomfutho wegazi ophezulu, yenhliziyo Umthambo isifo futhi senhliziyo. Kulezi zimo, umthamo we imithi kufanele zigcinwe ngaso izilinganiso aphansi, okwandisa kancane nge igebe elikhulu.

ezigulini esezikhulile nge ubude nokunwetshiwe izifo ezifana hypothyroidism, imishanguzo kufanele kuqale kancane kancane.

Ukuze ukwelashwa esikhundleni yendlala yegilo kubantu abanegciwane enganele adrenal cortex umsebenzi ngaphandle ukwelashwa okufanele (yesondlo) nge corticosteroids kukhona kungenzeka esibucayi adrenal (acute).

Lesi sidakamizwa ezinqunyiwe ngokuqapha in iziguli ngifundise ngesifo sikashukela.

Kwezinye izimo, ama-hormone egilo abangele noma babhebhethekisa myasthenic syndrome (odlule).

Izidakamizwa "Levothyroxine" futhi "Eutiroks": ngokungafani, ukubuyekezwa

Naphezu kweqiniso lokuthi kokubili timphawu asebenzayo ekwakhiweni efanayo eboniswe, yilowo nalowo kubo has izici zayo siqu. Lokhu kungenxa ngokuyinhloko yokuthi izingxenye ezengeziwe ezifakwe e ukwakhiwa yabo awafani.

Futhi, zikhona ezinye umehluko isenzo izidakamizwa. Ngokusho izimpendulo iziguli, umphumela ekwelapheni "Levothyroxine" izidakamizwa waphawula emva kwezinsuku 7-13, futhi esebenzisa "Eutiroks" - ngemva kwamasonto amabili.

Lapho esetshenziswa ngendlela efanele, imithi zokugcina ayinayo imiphumela eseceleni. Njengoba ukuba ngowokuqala, ezimweni ezingavamile, namanje kuholela nemiphumela engathandeki. Ngaphezu kwalokho, imiphumela emibi singenzeka ngisho nezinguquko ezincane umthamo.

Ezinganeni abanesifo sokuwa, noma nokuquleka isicelo "Levothyroxine" izidakamizwa kubangela ukuwohloka. Kepha Eutiroks izidakamizwa ' ", ngemva ukusebenzisa kwayo ukuwohloka okunjalo ningagcini.

Analogs sedivayisi yezokwelapha

Yini esikhundleni izidakamizwa "Levothyroxine"? Analogs yalesi izidakamizwa etholakala ngazo zonke Pharmacy. Phakathi kungenzeka leyo mithi okukhulunywe okulandelayo: «L-thyroxine-Pharmak», «L-thyroxine", "Bagotiroks", "A-Tirok" "Sodium levothyroxine», «L-thyroxine hexane", "Eutiroks», «L- thyroxine-Acre "," Tyro-4 "nokunye.

nobufakazi

Ngokwe impendulo kulabo babekade bemiswe izidakamizwa kubhekwe ke babhekane ngempela ngempumelelo kulo msebenzi. Nakuba kwezinye izimo, imithi kungadala ezinye imiphumela emibi.

Ngokusho kochwepheshe, ukuze ngokuzimela sebenzisa ama-hormone i-ejenti "Levothyroxine" akuvunyelwe nakancane. Ama-oda nje udokotela walo zingafundwa, kuye impilo isiguli kanye nokusebenza kwakhe ngabanye. Lokhu kungenxa yokuthi i-hormone izidakamizwa kungaba nethonya elinamandla kakhulu ngomzimba womuntu nangendawo yalo hormone ngokuvamile.

Kufanele kuphawulwe ukuthi imithi enye is hhayi Kunconywa. Phela, kalula nje ingabangela ukuhlanekezela imiphumela yokwelapha.