Izidakamizwa "Divigel" ngoba ekukhuleni endometrium: izibuyekezo kodokotela kanye neziguli, umthamo

inkinga yokungabi nenzalo zesifazane Namuhla ngempela oyingozi. izizathu ezahlukene - ukusuka ezihlukahlukene Izifo ukuvuvukala izitho zobulili, futhi izinkinga ohlelweni endocrine. Esinye sezizathu ezivamile - kuba anenombolo enganele estrogen zesifazane. Umsebenti wabo oyinhloko - ukulungiselela isendlalelo kwangaphakathi kwesibeletho ekwamukelweni neqanda.

Ukuqeda lokhu kusimo, abesifazane odokotela linqume nemithi equkethe i-hormone wathi. Enye yalezi izidakamizwa "Divigel" ngoba ekukhuleni endometrium, ukubuyekezwa iziguli ezinhle mayelana nayo, futhi abesifazane abaningi ikhulelwa ngokuphepha.

isidakamizwa

"Divigel" oluqanjwe abakhiqizi ngesimo ijeli transdermal elikhonza ukuqeda izimpawu yokuntula estrogen. Kuyinto Ukwakheka iyunifomu futhi zahlanganiswa ngo-aluminiyamu izikhwama.

Ngo ngezithako zawo has a gel:

• Estradiol e isamba 500 mg noma 1 g
• Carbomer 974P.
• Triethanolamine.
• Propylene glycol.
• 96% ETHYL utshwala.
• manzi ahlanzekile.

Isenzo kwemithi zomuthi

"Divigel" libhekisela eqenjini izidakamizwa ezisetshenziswa ukulungiswa kuphazamiseka kubangelwa ukunqamuka kokuya esikhathini empilweni yowesifazane. It has umsebenzi estrogenic.

Umthelela zokwelapha kufinyelelwa emva lokusebenza umsebenzi estradiol. Lokhu ejenti estrogenic equkethe "Divigel" ngoba ekukhuleni endometrium, e begazi, amakhemikhali yayo kanye nezimpahla kwemithi efanayo estradiol endogenous, kuhlelwe umqondo ngu amaqanda emzimbeni yabesifazane.

Uma ubheka ngezigaba izidakamizwa, le estradiol zihlanganisa amaqembu amaningana kwemithi:

1. Estrogens, progestins, homologues yabo futhi abantu abamelene nani.
2. Antineoplastic ama-hormone i-hormone abantu abamelene nani.

I asebenzayo izidakamizwa izidakamizwa igcwalisa ukuntuleka zesifazane-hormone i-estrogen yokwamukela futhi kuvusa umsebenzi ise kuhlose amaseli.

Pharmacokinetics

Estradiol eziqukethwe ijeli ngu okusheshayo lingena ngokukhululekile ku kuhlose amaseli, lapho uyiswa nucleus futhi akha khona ubuhlobo obuqinile la mangqamuzana estrogen. Lezi receptor atholakala kwezicubu ahlukahlukene. Kodwa iningi labo atholakala kwesibeletho, isibindi, amaqanda, amathambo kanye amabele.

Uphiko asebenzayo we ijeli - 17-beta-estradiol - has miphumela elandelayo:

• Kuvuselela ukuthuthukiswa insikazi uhlelo zokuzala.
• Kubangela lesikhumba ku ingono.
• Linikeza kwenqatshwa endometrium okuyinto imigqa kwesibeletho.

• Linikeza umjikelezo njalo esikhathini.
• It uyama ekukhiqizeni ubisi lwebele.
• It has nemiphumela procoagulant.
• Kahle kuthinta ukubuyiselwa inombolo amangqamuzana amhlophe egazi ngemva umonakalo ngemisebe.

Ngo estradiol yizimfanelo namanje eziningi ezibalulekile, ezinye zazo yilezi:

• Ukuvimbela isifo sokuqina kwemithambo yegazi.
• Ukwanda amazinga igazi HDL.
• Ukunciphisa LDL izinkomba.
• Ukwehlisa inani cholesterol.

Ngemva kokuma ukuya esikhathini e amaqanda womuntu wesifazane ukukhipha estradiol, lo msebenzi uhlala sesibindi adipose izicubu. amazinga estrogen encishisiwe kuholela yokuthi kukhona vasomotor ukuntengantenga ebonakaliswa ngamanzi, inkinga yokungalali kahle.

Omunye umphumela omubi yokuntuleka estrogen kuyinto ukukhumuzeka kwamathambo. Lokhu izifo umzimba ithumba ngokuyinhloko yomgogodla.

Lapho ethola estradiol ngomlomo ngesimo amaphilisi, imijovo kuba olwenzeka kancane kancane ketshezi emzimbeni, okuholela abalulekile blood pressure gxuma. "Divigel" ukukhula ukubuyekezwa endometrium kule ndaba ezinhle, isiguli lapho ukuthatha asikho isaziso nomfutho wegazi ophezulu.

Ijeli senziwa ngesisekelo utshwala, kodwa ngemva kokuthintana isikhumba, i-ethanol iyasha ngokushesha, futhi ketshezi asebenzayo lingena umgubuzelo angena egazini. Inani elincane estradiol imisiwe esikhumbeni, bese kancane kancane ezikhishwe egazini.

Phakathi Inkambo yokwelashwa "Divigel" isilinganiso phakathi estrone futhi estradiol ivela 0.4 kuya 0.7. I bioavailability zomuthi - 82%. Ukwelashwa kusebenta kuzoncika ngqo sendlela yokusebenzisa "Divigel" ekukhuleni endometrial.

ubufakazi

Ijeli, odokotela batusa ukuthatha njengomuntu hormone sokuvivinya abesifazane abaye baba ukuntula estrogen ngenxa yezizathu ezihlukahlukene. Umuthi ngokuvamile ebekiwe ukuqeda syndrome climacteric.

Ijeli ikufakazele ngokwaso njengoba isilinganiso izifo, ekuvimbeleni ukukhumuzeka kwamathambo. okubuyayo kuyinto "Divigel" ekukhuleni endometrial nge IVF njengoba kulungiselelwa ukuthi igcina sokukhulelwa evamile.

Umuthi iqondiswa e sokuphuza isilinganiso esengeziwe somuthi ngabanye lapho kukhethwa udokotela ukuba khona emtholampilo lapho le nqubo yase eyenziwa kokukhulelwa. Usisebenzise kangcono amaviki ambalwa ngaphambi akhulelwe uqhubeke kwalokho isikhathi esingangenyanga.

Ngemva sokukhulelwa ekunqanyulweni isicelo ngeke kwenziwe ngokuphazima kweso, njengoba kulokhu, kukhona ingozi isisu nokuguqulwa.

Uma wabelwe "Divigel" ekukhuleni endometrial, umthamo kuyakhethwa esimweni ngasinye ngokuhlukile. Phakathi nenkathi yokukhulelwa ukuhlela udokotela kufanele uqinisekise ukuthi endometrium hypoplastic ukuze sikhuthaze nge-ovulation is ifanelekile ukusebenzisa ijeli kuhlangene nezinye izidakamizwa hormone. Esimweni ngasinye, le mishanguzo ukwelashwa kuzohluka.

Izimo

Ngaphambi wokuqonda ukuthi ukuthatha "Divigel" ngoba ekukhuleni endometrium, kufanele uqiniseke ukuthi azikho contraindications lokhu, banayo imali eyanele izidakamizwa. Phakathi kwabo, avame yilezi ezilandelayo:

1. Hypersensitivity kuya izingxenye.
2. Ukuba khona umdlavuza webele, noma uma ngabe kube emlandweni.
3. izimila ebulalayo e ezikhiqiza amaqanda, kwesibeletho.
4. Ukuba khona izimila ingozi e izitho zangasese esifubeni.
5. Nezici ezithile ukuze lesizalo ukopha.
6. Hyperplasia Endometrial.
7. izimila pituitary.
8. Izifo ukuvuvukala kwezitho zobulili.
9. estrogen Ukwandiswa okuqukethwe.
10. Thrombophlebitis.
11. Ukuba khona izimila esibindini.
12. Izimpawu of kwegazi cerebral palsy.
13. Isikela cell anemia.
14. Ukwephula fat umzimba.
15. Ngifundise ngesifo sikashukela.
16. Tifo letibangwa maphakathi nendlebe.

ngokuqapha ikakhulukazi ngenkathi usebenzisa gel kufanele libukwe kwabesifazane waphawula:

• isifuba somoya bronchial.
• ukuhlaselwa Migraine.
• High blood pressure.
• Senhliziyo, ukwehluleka kwezinso noma hepatic.
• Isifo senhliziyo.
• Bethambekele edema.
• Fibrocystic webele isifo.

Ukuba bonke laba contraindications izixwayiso ebonisa ukuthi ngaphambi kokubuza umbuzo indlela smear "Divigel" ngoba ekukhuleni endometrium, kuphoqelekile ukuvakashela onguchwepheshe, futhi naye ukuze kuxoxwe ngalolo daba.

sequela engadingeki

Every body lihlukile ngendlela yalo Uyabubona izidakamizwa, ngakho ngisho engekho contraindications ukusetshenziswa akusho ukuthi awunayo yini imiphumela emibi. Phakathi ukwelashwa, angase ijeli ezilandelayo:

1. Kusukela isimiso sezinzwa: ikhanda, isiyezi, ukuquleka, migraine, ukucindezeleka.
2. On the ingxenye izitsha inhliziyo negazi: thrombosis futhi ukwanda ziphikelele blood pressure.
3. Isimiso sokugaya ukudla bungene angaphendula ngu isicanucanu, ukuhlanza, ubuhlungu esiswini, ukubuyisa.
4. On the ingxenye uhlelo zokuzala singenzeka: ukopha lwesitho sangasese sowesifazane, khulula ophikelelayo, ayanda endometrial, izinguquko libido, lesizalo umdlavuza umzimba.
5. Uhlelo endocrine ongabonisa zimpawu ezilandelayo: ukuvela isisindo okweqile, webele engorgement.

Ngekusetjentiswa eside ijeli uketshezi ekuqongeleleni kungenzeka emzimbeni, okuholela edema. Njengoba sazi ukuthi izidakamizwa isetshenziswa ihlelwe ngokulandelana kwezihloko, ukuqubuka iguliswa, ukulunywa zingavela isikhumba.

Ezinye iziguli abasebenzisa "Divigel" ngoba ekukhuleni endometrium, shiya impendulo engeyinhle ngenxa ukubonakaliswa njalo amathuba okuba nemiphumela engemihle ezifana angaboni kahle kanye candidiasis eqinile lwesitho sangasese sowesifazane.

Ukuze kungabikho muntu ophathwa imiphumela okungafunwa, ukusebenzisa izidakamizwa kumele ngokuqinile udokotela.

Indlela "Divigel" ngoba ekukhuleni endometrium

Umuthi nge tolerability ezinhle futhi ukungabi khona Izimo ingasetshenziswa ukulapha eside. Ngesikhathi besanda kuqala ukwelashwa, umthamo 1 g gel. Ngemva izifundo eziningana, ukulungisa isithombe, isiguli, umthamo kungase kukhule noma kwehle.

Kubalulekile ukuthola udokotela hhayi kuphela lapho ukufezekisa "Divigel" ngoba ekukhuleni endometrium, kodwa futhi lokho usuku umjikelezo wokuya esikhathini uwubufakazi kubalulekile ukuqala ukwenza.

Ngokwe isitatimende, ijeli okumele asetshenziswe ukuhlanza isikhumba kule aphansi esiswini, okhalweni, emahlombe, izingalo noma ezinqeni. Okwenza kube efiselekayo ngesikhathi esisodwa futhi ngesikhathi esifanayo usuku ngalunye, endaweni isicelo kumele alternated.

Le ndawo elilungile kakhulu isicelo kubhekwa ubukhulu 1-2 zezandla. Indawo ukucutshungulwa akunakwenzeka ihora ngemva ukusetshenziswa ijeli wageza.

Uma owesifazane akhohlwe ukusebenzisa ijeli, khona-ke kumelwe kwenziwe kungakapheli amahora angu-12 emva isicelo esimisweni izidakamizwa. Uma kuthatha isikhathi eside, kubalulekile ukuba bahlehlise ke kuze kube ngokuzayo.

Uma umthamo weqiwe

Abantu abaningi bakholelwa ukuthi uma uthatha imithi ngemithamo ezinkulu, ukuqala umphumela omuhle kuzokwenzeka ngokushesha, kodwa lokhu akulona iqiniso. Izimpawu ezilandelayo lungase lubonwe ayephuli izincomo udokotela ku ukusetshenziswa "Divigel" futhi yedlule Isikali:

• Soreness esifubeni.
• Ukuvuvukala.
• Ukuvela ukukhathazeka.
• Ukucasuka.
• Isicanucanu.
• Ukuhlanza.

Uma ubona lezi zimpawu kumele kuxoxiswane ngazo nodokotela wakho futhi ushintshe umthamo noma ukhansele ukusetshenziswa kwezidakamizwa.

"Divigel" lihambisana namanye amanxusa

Uma udokotela ekunika "Divigel", qiniseka ukuba pre-wokuqonda lokho imithi isiguli kuthatha. Estradiol kungase kudingeke miphumela elandelayo:

• Thuthukisa ukusebenza izidakamizwa lipid-ukwehlisa.
• Ukuze buthaka umthelela izidakamizwa, ezibandakanya hormone ocansini besilisa.
• Buthaka umphumela izidakamizwa ezisetshenziselwa sikashukela.
• Yehlisa ukusebenza izidakamizwa ngokumelene nomfutho wegazi ophezulu.
• Attenuate umphumela oqabulayo anticoagulants.

Aphinde asheshise umzimba estradiol co-abaphathi:

• Barbiturates.
• analgesics iNarcotic.
• Agents esetshenziselwa izinto zokubulala izinzwa.
• Eminye imithi eqeda sokuwa.

Ukuphumelela "Divigel" kakhulu encishisiwe, uma isetshenziswa ngesikhathi esifanayo ne nemithi ethile elwa namagciwane, kanye "Phenylbutazone". ungaba naye ukuthatha folic acid izinsiza yegilo indlala ukwandisa umphumela.

izincomo ezithile

"Divigel" ukukhula impendulo endometrial kusukela odokotela siya oqondile, kodwa ochwepheshe batusa ukuba linqume emva ukuhlolisisa ngokucophelela izinkulumo nesineke futhi enemininingwane naye.

Ukuze ugweme nemiphumela engathandeki, owesifazane kufanele ahlolwe egcwele izitho okhalo kanye nezindlala mammary. Kufanele kube njalo nakulo lonke ukwelashwa.

Sixoxe, "Divigel" ngoba ekukhuleni endometrium kuphi smear kwezinye indawo. Khona-ke kubalulekile ukuthi ugeza izandla ngamanzi nensipho, futhi ningathinti iso.

Musa ukusebenzisa ijeli endaweni ye thoracic kanye nezindlala ocansini, kanye nezindawo lapho kukhona ukucasuka. Ukusebenzisa "Divigel" Zingaphazamisa inqubo ukukhiqizwa kwamaqanda. I zamagama hormone incike lokuhlushwa i-estrogen igazi, uma uthola kubo kusukela ngaphandle kungaba siphukile, ngakho ukuthatha izidakamizwa uma uhlela ukuba akhulelwe imele ngokucophelela okukhulu.

Ukusebenzisa izidakamizwa phakathi nokukhulelwa kanye lactation

Naphezu kweqiniso lokuthi "Divigel" ngoba ekukhuleni endometrium Izibuyekezo IVF uthola okuhle, uma sokukhulelwa kwenzeka kufanele nixoxe amacebo ukuqhubekisela phambili ngokusetshenziswa kwayo nodokotela wakho. Uma uphethwe i isikhundla ezithakazelisayo kowesifazane akuyona ungaqiniseki ke, cishe, udokotela uzokwenza isinqumo ukuyeka ukushayana ngamaphutha abazali izidakamizwa.

izifundo ezihlukahlukene ibonisa ukuthi yesikhathi esisodwa kanye nokusetshenziswa esikhethiwe ijeli ngesikhathi sokukhulelwa akakubangeli imiphumela teratogenic, kodwa ingozi impilo ingane ikusasa akusilo zinkulu.

Ngesikhathi sokuncelisa ibele kungavunyelwe ukusebenzisa ijeli.

Impilo yabesifazane - into ethambile, kungaba luntengantenge ngesikhathi esibi kakhulu. Akekho umuntu othanda ukuthi izinto umzimba wakho ngamakhemikhali, kodwa zikhona izikhathi lapho wena nje badinga "Divigel" ngoba ekukhuleni endometrium, ukubuyekezwa, kulapho uthola esihle. Kahle lwaleli izidakamizwa odokotela nje kuphela kodwa futhi iziguli, ikakhulukazi ukuya esikhathini.

Ungabi kahle ngokuhlale sikhumbula waphinda ukuthi noma yimuphi umuthi Kufanele umise onguchwepheshe oqeqeshiwe kuphela, asikho isidingo ukuthatha imithi sína kangaka ku iseluleko abangane noma ubone ukukhangisa kumabonakude. Nakekela impilo yakho!