"Celecoxib": yokusetshenziswa, ukubuyekezwa. izidakamizwa analogue

Ukwelashwa nokuvikelwa yizifo ezihlobene nokungabikho ukulimala uhlelo zemisipha, izimfuno ezivela ezimakethe ezithaka imithi ukwakha imithi emisha ayinayo imiphumela eminingi engemihle futhi ngekhono elingcono. Ososayensi baye bathola futhi kuhlelwe umqondo isizukulwane esisha non-steroidal izidakamizwa eqeda ukuvuvukala ngesisekelo celecoxib. Lezi zidakamizwa ziye encishisiwe ubuthi futhi kangcono ikubekezelele umzimba.

Incazelo "Celecoxib" izidakamizwa

Into celecoxib uba nombala ugodo ephuzi futhi libhekisela coxibs iqembu okuyinto abonise okusithiyayo ukukhetha uhlobo lwesibili cyclooxygenase. Ukuthaka imithi ngendlela esekelwe compounds samanje ifa liphinyiselwe izakhiwo eqeda ukuvuvukala kanye analgesic. Umuthi yasekuqaleni ngesisekelo celecoxib kubhekwa yinkampani American "Pfizer" isidakamizwa "Celebrex". kwaba ifundelwe bahlola izici pharmacodynamic of ubuthi emzimbeni womuntu.

Enye ukuthaka imithi eliqukethe asebenzayo izidakamizwa celecoxib nganabile, kuhlanganise nokusetshenziswa "celecoxib".

amafomu Isikali

izidakamizwa Itholakala kanzima gelatin amaphilisi ngesikhathi umthamo isithako esisebenzayo, 100 mg kanye mg 200. Ngokungafani nabanye abangewona steroid ejenti eqeda ukuvuvukala, ayinayo indlela umthamo njengoba amafutha, ijeli, izixazululo komjovo noma ukumiswa. Kwabanye abantu ngephutha ngokuthi ifomu ukukhululwa "Celecoxib" izidakamizwa - amaphilisi, nakuba sikhuluma amaphilisi.

isakhiwo

Isithako esebenzayo celecoxib ketshezi isamba 100 mg kanye mg 200. Ukwakheka amaphilisi zihlanganisa izingxenye asizayo ukuthi anika ukugcwaliswa, le flowability nokuzinza ingxube granulated. Lezi zihlanganisa i-lactose, sodium lauryl sulfate, polyvinylpyrrolidone (K30), i-sodium croscarmellose, magnesium stearate.

Attached manual izidakamizwa "celecoxib" imfundo inalokhu ukwakheka kanye ukubukeka kwe-shell gelatin capsule. Ngokusho incazelo, kubukeka zomile, babe cishe mhlophe futhi kumakwe ngezibonakaliso "100" noma "200", esisogwini band okwesibhakabhaka noma ophuzi, ngokulandelana. Lokhu kuvumela ukuhlukanisa amaphilisi nge imithamo ehlukene. Ukubunjwa uyinki ophuzi noluhlaza okwesibhakabhaka nazo zaveza imininingwane ekhombisa udayi ingozi umzimba.

izidakamizwa ezifanayo

Imithi umkhiqizo "Celecoxib", analogue zazo iqukethe asebenzayo izidakamizwa celecoxib, kungaba abonise nomphumela ofanayo zokwelapha ku-osteoarthritis we lwamathambo omuntu.

Umuthi yasekuqaleni "Celebrex" futhi "Celecoxib" yalo ejwayelekile, "Artoksib", "Zitsel", "Revmoksib", "Ranseleks" ezibhekwa nemithi nezilandiso. Nokho, intengo isigaba sokuqala izobiza umyalelo ezidlula eqolo ngaphezu kwanoma nozakwabo.

Lapho belungela ukuya khona "Celebrex" iqukethe celecoxib ngesikhathi umthamo mg 100 no-200 njengoba nomuthi "celecoxib". izingxenye Asizayo we capsule futhi imvilophi yayo kungahluka kokubili Ukwakheka qualitative ambalwa ukuthi akuphazamisi nezici zabo. Mayelana nesimo ukukhululwa ejwayelekile "Celecoxib" izidakamizwa analogue akhiqizwa kuphela kanzima gelatin amaphilisi ukusebenza kwangaphakathi.

Kukhona -non-steroidal anti-inflammatory ejenti, cyclooxygenase ngokulinganayo kusebenza uhlobo lwesibili kodwa umehluko kokuba lichaza ekwakheni ingxenye iyasebenza, pharmacokinetic nezici pharmacodynamic. Lezi zinto zihlanganisa sulfonamide kwakwakhe nimesulide okuyinto ngezilinganiso yansuku zonke mg 200 ngempumelelo liphatha izimpawu osteoarthritis ne-rheumatoid arthritis. Ukwakhiwa ngokusekelwe umphumela wawo eqeda ukuvuvukala kanye analgesic ngu ezivimbela cyclooxygenase yesibili futhi ngezinga elincane - uhlobo lokuqala, kuthinta ezihlukahlukene mediators ubuhlungu nokuvuvukala.

Njengoba nimesulide, celecoxib kuyinto besigaba sulfonamide izidakamizwa, futhi ngezilinganiso yansuku zonke mg 200 aqede izimpawu osteoarthritis. Akukona zivimbela uhlobo cyclooxygenase kuqala futhi enza inombolo encane mediators ubuhlungu nokuvuvukala.

Enye indlela yokwelapha coxibs ekuphathweni temlomo kukhona izinhlobo komjovo we ama-NSAID. Omunye izinzuzo main of "Celecoxib" umkhiqizo - intengo. Imijovo (ampoules ngoba umjovo) nezinye izidakamizwa ezingekho steroidal anti-inflammatory abiza ezibizayo, kodwa enjalo umjovo kahle kakhulu kunanoma umphumela kusukela ukusetshenziswa kwezidakamizwa amafomu okuqinile.

mshini wezenzo

Izidakamizwa "Celecoxib" - umuthi esimele isizukulwane esisha ejenti nonsteroidal eqeda ukuvuvukala, eqeda ukuvuvukala, analgesic, umsebenzi antipyretic. indlela yayo yesenzo lihlotshaniswa ekuvimbeni kumiswa prostaglandins ukuvuvukala ngokunciphisa umsebenzi Cox-2.

ukusabela okuvuthayo kushiya lokungeniswa ohlobo yesibili cyclooxygenase, esikhundleni salokho ngesivinini ekuqongeleleni prostaglandin zamagama kanye izinto ezithuthukisa ukuvuvukala. State eba ukuvuvukala futhi ubuhlungu.

uhlobo Cyclooxygenase kuqala akuphazamisi zokwelapha umthamo "celecoxib" ukulungiselela. Yokusetshenziswa uchaza inertia zomuthi maqondana nalolu enzyme nezenzo zawo izinqubo bokuphila okwenzeka amaseli emathunjini ipheshana platelet izakhiwo.

Futhi, imiyalelo inikezwe idatha umthelela izidakamizwa izinso. Ngaphansi isenzo celecoxib lingaphansi kuka uboniswa umchamo Ukwakheka prostaglandin E2 futhi F1-6-keto-prostaglandin, kodwa akashintshi ukwabiwa B2 11-dehydro-thromboxane, okhombisa imithi umphumela zikhethe.

Ukusebenzisa izidakamizwa "Celecoxib" aliholeli ukwehla izinga filtration ku glomeruli izinso asebekhulile kanye in iziguli esingamahlalakhona kwezinso.

Izinkomba ukusetshenziswa

Ngokusho izici pharmacodynamic kwesicelo ekulungiseleni "celecoxib" kuyoba ngempumelelo ekwelapheni isifo samathambo onaso sibe futhi psoriatic, ukuvuvukala ezingamahlalakhona ubuhlungu yomgogodla kanye sacroiliac amalunga osteoarthritis.

Ngenxa impahla yayo analgesic esetshenziselwa isimo esibuhlungu ubuhlungu zemisipha emva kuhlinzwa ukwelashwa, dysmenorrhea, okuyinto kuhambisana esikhathini okubuhlungu. Umthelela eqeda ukuvuvukala zomuthi kuhloswe ukunciphisa amaqhubu kanye polyp ku colon kanye ingemuva e sitholakele "polyposis adenomatous".

Indlela

Thatha imithi "Celecoxib" yokusetshenziswa ngaphakathi incoma hhayi ngokuxhuma ukudliwa kokudla. Amaphilisi musa ukuvula hhayi baba imilutha ye, futhi kugwinywe lonke ngokuphuza amanzi amaningi.

Inani eliphelele celecoxib, okuyinto lingathathwa ngelanga kuyinto 0.4 g Lokhu ukulungiselela isetshenziswa ngokweqile kuphela ezimweni ezingajwayelekile.

yezinkinga senhliziyo kungabangela ebulilini futhi ukwelashwa isikhathi eside ne izidakamizwa "Celecoxib". Umhlahlandlela uqukethe ulwazi imithamo emincane ngoba impatho lingaze lokufunda ngalunye. Unikeza izincomo mayelana nokusetshenziswa iDemo.

Ukuqeda izimpawu ezihlobene ne-osteoarthritis, futhi ankylosing spondylitis, nsuku zonke ukuthatha izikhathi elilodwa noma amabili ne 200 mg zomuthi.

Ukuqeda izimpawu samathambo usebenzisa umthamo zonke izinsuku we-200 noma angu-400 mg, okuyinto sathathwa njengoba kabili.

Ubuhlungu dysmenorrhea eyinhloko iphathwa ngosuku lokuqala umthamo eliphezulu 400 mg, ne reception kungenzeka kokuchunyiswa 200 mg, ngelanga usebenzisa 200 mg izikhathi 2 ngosuku.

Asebekhulile, kanye neziguli ukuba degree omnene isibindi asanele noma okuncane esingamahlalakhona kwezinso, akukho zokubala kabusha of umthamo Kwenziwa.

isisindo okuphansi (ngaphansi kuka-50 kg), kobukhulu isilinganiso yokwehluleka kwesibindi ukusebenza - izigaba idatha for iziguli ziphathwe ngemithamo eliphansi imithi kadokotela.

Ngokuvamile, ukwelapha izinqubo ukuvuvukala emalungwini esetshenziswa ekwelashweni izinhlelo esekelwe ukusetshenziswa kwezidakamizwa eziningi amafomu ahlukahlukene umthamo. Hlanganisa "celecoxib" capsule, amafutha, noma gel-uhlobo ukufudumala "Apizatrona" noma "finalgon. ukusetshenziswa ngezihloko ezihlukene kubangela nomphumela kungokwesikhashana, ngakho bajwayele kanye nezidakamizwa i-reception zasendlini.

Lokhu sivimbela ukusetshenziswa

Akubona bonke iziguli izifo ngisho namalungu, ungakwazi ukuthatha izidakamizwa "Celecoxib". Yokusetshenziswa iqukethe uhlu izifo kanye nezimo lapho kuzohamba ngaphezulu ukulimaza kuka okuhle. Lezi zihlanganisa:

• isifuba somoya, isimo iguliswa ngenxa yesenzo aspirin nezinye izidakamizwa nonsteroidal eqeda ukuvuvukala;
• ukusebenza yokutakula elihlobene ne ukuxhumelela imithambo yenhliziyo dlula ngokuxhunyelelwa ;
• exacerbation of isilonda peptic;
• isisu ukopha emathunjini;
• ukuvuvukala mucosa emathunjini;
• ukuhluleka kwenhliziyo;
• izifo ischemic we imisipha yenhliziyo;
• ukulahlekelwa imithambo neuropathy nezitsha cerebral nge kahle igazi cerebral ukugeleza;
• hepatic nedostatochnosttyazheloy ukuma;
• ukuhluleka ezinzima kwezinso;
• yokuzala;
• uncelisa ingane;
• ezingaphansi kweminyaka engu-iminyaka eyishumi nesishiyagalombili;
• hypersensitivity kuya excipients;
• anda ezifweni ukuba ingxenye sulfonamide.

Ngekusetjentiswa ngokucophelela lesi sidakamizwa "Celecoxib" kufanele kube abantu abanezifo yokusetshenziswa pheshana emathunjini elihlobene ne peptic isilonda ukopha esikhathini esidlule, isifo amagciwane lwamafinyila bohlobo lwe-Helicobacter pylori.

Ukugcinwa kwamanzi emzimbeni nezicubu ezithambile edema, iziyaluyalu kwesibindi yesibili esiteji, inhliziyo futhi semithambo izifo, emzimbeni, lapho ukwanda ezingeni cholesterol oketshezini olungenambala lwegazi waphawula lipid umzimba, isifo sikashukela, ushukela, izifo ukuphathwa kwabathintwayo e ezinzima futhi esiyimbangela esiphezulu ukusebenzisa ngokucophelela izidakamizwa "celecoxib" ngaphansi kokuqondisa kukadokotela.

side effects

Naphezu impumelelo ezintsha kudalwa isizukulwane esisha coxibs, lezi izinto nezidakamizwa okusekelwe kuzo akuzona elingenalo engemihle.

Lokuhambisana izidakamizwa "Celecoxib" yokusetshenziswa, kobufakazi nesineke nochwepheshe - mithombo aqukethe ulwazi ngemiphumela engemihle ukuthi kungenzeka izitho ezibalulekile.

I kungenzeka nomthelela omubi isimiso sokugaya ukudla bungene libhekene NSAID-gastropathy, ubuhlungu esiswini, isicanucanu, ukuhlanza, isilungulela, wehlise isidingo ukudla kanye nesifo sohudo. ukusetshenziswa eside ebulilini kungabangela ulceration ukopha e ulwelwesi lwamafinyila we isisu namathumbu, ukopha izinsini, kusebenze ngokweqile kwesibindi transferase.

iziyaluyalu Nervous ziyabonakala injabulo, ikhanda, isiyezi, somnolence, ukuqwasha, uthi sokucindezeleka.

Ithonya esimiso senhliziyo nemithambo yegazi ngenxa yokucindezeleka okwandayo esikhathini yegazi tachycardia.

Ukulungiselela "celecoxib" kunciphisa ukumelana nezifo ezithathelwanayo umgudu wokuphefumula, okuyinto ungaboniswa ukuthuthukiswa sinusitis, rhinitis, pharyngitis, ubuhlungu ekhaleni nomphimbo, ukukhwehlela, dyspnea, bronchospasm.

Umthelela izidakamizwa imizwelo kubangela nokuncipha bezibona sokuzwa kanye ukubukeka tinnitus.

On uhlelo urinary kuthinta izidakamizwa "Celecoxib" ukuze nizitholele ukwehluleka kwezinso nge ukuthuthukiswa edema syndrome.

Ngokuphathelene izitho igazi-ukwakha, umuthi kungabangela ukubonakaliswa agranulocytosis, ukuntuleka kwegazi emzimbeni, leucopenia, thrombocytopenia.

Ukuqubuka kungenzeka nge ukubukeka pruritus iguliswa, urticaria, photosensitivity, angioedema e ebusweni esifundeni, emikhawulweni, Izitho zangasese.

Izici reception

Izidakamizwa "Celecoxib" kusimo esingokwemvelo kuhlotshaniswa kwengozi nemiphumela emibi esimiso senhliziyo nemithambo yegazi okuholela thrombosis, infarction ka esivimba amanzi emangalisa imisipha nonhlangothi. Ikakhulukazi ukwanda ingozi ngesikhathi abaphathi ezingalapheki imithi iziguli okungekho kukhona izifo zenhliziyo nemithambo yegazi.

Ukuze kuncishiswe ingozi yezinkinga ezifana in iziguli ukuthatha izidakamizwa "Celecoxib" ukunquma umthamo ephansi okungenani esifushane ukwelashwa. Isiguli kufanele uxoxe nodokotela wakho izimpawu kungenzeka yesifo nayo ukuthola iseluleko sendlela aphendule ngaleso sikhathi ezizokwenzeka ngaso.

sebenzisa inhlanganisela acetylsalicylic acid ngemithamo okuncane izidakamizwa "celecoxib" Ukuze banciphise izimpawu zenhliziyo. Izibuyekezo lodokotela zibonisa umphumela antiplatelet -aspirin mncane igazi uma nithatha coxibs, ezingenakho izakhiwo ezifana anti-thrombotic. Ngokuvamile, inhlanganisela enjalo kuboniswa ezigulini esezikhulile iziyaluyalu of the system zemisipha kanye uhlelo senhliziyo nemithambo yegazi, ubuthi emathunjini luyanda lapho non-abakhethayo non-steroidal izidakamizwa eqeda ukuvuvukala. Kodwa ukusetshenziswa celecoxib izidakamizwa nezinye ama-NSAID is hhayi Kunconywa.

Ukuze iziguli-high blood pressure, ukuqapha okuqhubekayo lokhu ipharamitha lapho ithola "Celecoxib" izidakamizwa.

Ngokukhethekile kufanele inikwe ukuqapha isimo umzimba lihambisana anticoagulant (warfarin) kanye izinto antiplatelet (acetylsalicylic acid, clopidogrel) usebenzisa inhibitor abakhethayo (citalopram, sertraline), ezivimbela serotonin reuptake inhibitor ka CYP2C9 isozyme, amafomu ithebhulethi glucocorticosteroids.

Umuthi 'celecoxib "ikhuthaza ukukhiqizwa kwe izinto prostaglandin, okuyinto kuthiye ketshezi emzimbeni futhi kwenyuswe ukuthuthukiswa edema. Ikakhulukazi qaphela ekwelapheni le mithi kudingeka kube ngabantu abaphethwe senhliziyo esilimele ukwehluleka nomfutho wegazi ophakeme. Kufanele uyeke ukuthatha "Celecoxib" izidakamizwa uma kukhona izimpawu zokuzikhukhumeza kwezicubu.

Iziguli izinso iziyaluyalu ukwelashwa coxibs kufanele kuhambisane ebhekiwe izinkomba zabo ukhiye.

Lapho amanzi emzimbeni ngokuthatha izidakamizwa kungenzeka kuphela emva rehydration rehydration Yiqiniso.

Reception "celecoxib" izidakamizwa antipyretic ngenxa yesenzo kuholela inkinga index zokuxilonga, njengoba lokushisa ephakeme phakathi ukuthuthukiswa izimo ezithathelwanayo.

Isenzo zomuthi kungadala kwezinso e kokusebenza kwesibindi, ikakhulukazi abantu nga pre-existing iziyaluyalu kwesibindi. izimpawu ezinamandla ezihambisana kwesibindi fulminant, isibindi nekrozomtkaney. Izimo ezinjalo zenzeka ngokushesha, kodwa kuphela ngemuva kwezinsuku ezingu-30 ngemuva kwesicelo "celecoxib" ukulungiselela. Khona-ke ufuna ukuqapha ukusebenza ekwelapheni isibindi lesi sakhiwo, futhi uma kwenzeka yokunqotshwa esindayo kufanele ngokushesha ukukhansela aphoyintimenti.

Izibuyekezo ekwelapheni "Celecoxib"

izidakamizwa Nonsteroidal eqeda ukuvuvukala wenziwa kuphela kadokotela. Imiphumela ukusetshenziswa "Celecoxib" izidakamizwa izibuyekezo isinyathelo kwakhona okuxubile. Omunye imithi esiza ukuba sibhekane ngokuphumelelayo izinqubo ukuvuvukala kwamalunga, abanye kuba kuphumelele futhi kubangela eziningi izigigaba ezingezinhle.

Njengoba iziguli ezingaphezu ukuhlola izidakamizwa "Celecoxib"? Izibuyekezo ibonisa eziningi izinkinga: ubuhlungu esiswini, sezinso, izinkinga esikhathini. udokotela okunjalo iziguli uqhuba yokukhansela nomuthi futhi esabela ukuba elashwe ngenye indlela.

Ngokusekelwe imicabango yabantu iziguli on imiphumela imishanguzo amalunga avuvukele, kumele kuphetfwe ukuthi kuyaphumelela ekulweni nesifo sokuqaqamba kwamalunga. Ukuqeda izimpawu ubuhlungu, ukuvuvukala kwezicubu endaweni ethintekile bemvelo okungamahlalakhona, iziguli ekwindla kanye nezinga entwasahlobo ka ukwelashwa "Celecoxib". It is esetshenziswa abasubathi ukubheduka amalunga omzimba.

Ikakhulukazi nomuthi izenzo ngempumelelo lihambisana ukufudumala yokugcoba nama-gel for isicelo nezokusigcoba. Nokho, ngokuvumelana nezincomo eziqukethwe yokusetshenziswa inikezwe NSAID zisebenzisa amafishane, ukuze ugweme ukucindezeleka izinso, isibindi, inhliziyo futhi isisu. Kungenjalo hhayi ukugwema ukwehluleka emsebenzini lezi zindikimba.