Buserelin edepho - incazelo kanye isicelo izici

Kukhethwa umuthi hormone kufanele esekelwe ukutadisha ngokucophelela izimpawu kanye ukuhlonza ngokucophelela ingozi nemiphumela engathandeki yalawo maphilisi.

Ukulungiselela "Buserelin Depot" eqhathanisa kahle nabanye esebenza yaso ephezulu okungenzeka eliphansi izimpawu ezingezinhle. He is ilungu hormone anticancer ejenti.

Isenzo kwemithi zomuthi

Isenzo siqukethe buserelin antigonadotropnym, anti-androgenic, anti-estrogen, anti-isimila imiphumela. Izidakamizwa izidakamizwa "Buserelin Depot" ukuncintisana bophezela receptor amangqamuzana secreting gonadotropin-ukukhulula isici (basuke isakhiwo namanoni aphezu anterior we indlala pituitary).

Ngo esigabeni sokuqala okokufaka izidakamizwa siyenzeka ukukhuphuka lezivakashi e lokuhlushwa LH futhi FSH (i-hormone gonadotropic), labelwe i-pituitary okuyinto kuholela zangasese Gomonov okuqukethwe. Ngemva 14 - 21 izinsuku Ukuvinjwa kusho umsebenzi gonadotropic ngu feedbacks negative, okuholela ekuncipheni abalulekile LH futhi FSH, futhi, ngenxa yalokho, futhi ukwehla ekukhiqizweni kwama-hormone ocansini. Ngakho, owesilisa testosterone lokuhlushwa incipha, isifinyelele ezingeni lapho kuqinisekiswa emva orchiectomy (castration yezokwelapha). Abesifazane izidakamizwa umphumela "Buserelin Depot" lehliselwa ezingeni estradioda ukukhiqizwa ekhona esikhathini posklimaktericheskom.

Ukusebenzisa izidakamizwa "Buserelin Depot"

It is lisetshenziswe ekwelapheni umdlavuza wendlala yabesilisa, kwezinye izimo, wasebenzisa ukucindezela ukukhiqizwa testosterone ku testes. Futhi esetshenziswa wokwelapha isifo somdlavuza webele (izifo ama-hormone engaphansi, esibonakala by ukukhiqiza eliphezulu estrogens noma livela endometriosis). Ezinye izifo, ziphatha "buserelina Depot": fibroids lesizalo, Hyperplasia endometrial, eqhuba uhlelo IVF ekwelapheni ukungabi nenzalo.

Izimo kanye nezincomo ekhethekile

Hypersensitivity, orchiectomy, ukukhulelwa, lactation. Okumele kuqashelwe ngokuthatha izidakamizwa e-pathology we ngomgudu womchamo ezingeni Ukudlulela vertebral, umfutho ophakeme wegazi, isifo sikashukela, nokucindezeleka. Buserelin edepho nokukhulelwa - imiqondo engahambelani.

side effects

Isiguli ingase ikhononde umkhuhlane phezu ingxenye isimiso sezinzwa esiyinhloko ngesimo ikhanda, ukwethuka, ukuqwasha, ukulahlekelwa amandla okukhumbula, kwehle okuhlushwa, isiyezi, ukungazinzi ngokwezomnotho ngokomzwelo, futhi ngezinye izikhathi ukucindezeleka. It okungase kuthintwe tinnitus noma ingcindezi yeso, angaboni kahle noma ukuzwa. It ngokuvamile ingaba "ukushisa komzimba." Ngo ngesonto lokuqala ukwelashwa abesifazane waphawula psevdomenstruatsiya ke wabeka isitho sowesifazane somile, kungenzeka ithambo demineralization, kwehle libido. In amadoda, lesi sifo kungase zaba zimbi kakhulu owokuqala 2 - 3 amaviki, noma avele gynecomastia, potency encishisiwe. Nse efanayo kungenzeka: sokuzincisha ukudla, iziyaluyalu dyspeptic. Buserelin edepho kanye notshwala akuhambisani. In iziguli nge nomfutho wegazi ophezulu kungase kwandise ingcindezi, kwenhliziyo. Kusukela komzimba kwenzeka: ukulunywa, ukuqubuka, bronchospasm, ukushaqeka anaphylactic. Ukushintsha izinkomba laboratory: dyslipidemia, Hyperglycemia, ukwanda transaminases futhi bilirubin, thrombocytopenia futhi leukopenia.

Izimiso izidakamizwa

ekuphathweni esicutshini: iqondiswa ngokushesha ngemva ukulungiswa ukumiswa.

- lapho wendlala isimila njalo emavikini 4 at 4.2 mg.

- endometriosis - yethulwa ezinyangeni ezingu-4.

- nge lesizalo myoma -3 izinyanga.

- ukungazali - 4.2 mg.

ekuphathweni Intranasal:

- for ekwelapheni izifo zesifazane ezichazwe ngenhla - iqondiswa ngaphakathi komgodi acinene 900 mg / ngosuku (umthamo owodwa, izikhathi 3 ngosuku), kusuka 1 - 2 izinsuku nomjikelezo wokuya esikhathini.

- ukungazali 600 mg / ngosuku, 1 umthamo ku acinene ingaphakathi kane ngosuku. Uma waveza kakhulu ukuvinjelwa kwesimiso sokuzala, umthamo kuyehla kube izikhathi 2.

Amanye amanothi:

- Ukwelashwa umdlavuza wendlala Kwenziwa konke ukuphila;

- elwa ne-androgen iqondiswa amasonto ama-2. futhi amasonto ama-2. ukwelashwa nge buserelin, kuvimbela izinkinga ezingase zenzeke ngesikhathi emasontweni okuqala ukwelashwa;

- esikhathini sokuqala ukwelashwa abesifazane zingavela simila wesibeletho;

- kufanele ukuvimbela ukukhulelwa kanye umuthi kokuthola imithi ukwelapha buserelin, kodwa ezinyangeni zokuqala 2 kuyadingeka ukusebenzisa izindlela ezingekho hormone zokuvikela;

- kuba nomphumela omuhle ekwelapheni izidakamizwa i-endometriosis surgically ngokunciphisa ukuvama ukwehluleka kwesikhashana.

Ukuxhumana nezinye izidakamizwa

Buserelin kunciphisa umphumela izidakamizwa hypoglycemic. Kungase kubangele hyperstimulation wesibeletho, uma asetshenziswe kanye nezidakamizwa ehlanganisa hormone ocansini.