Analog "Charter": phambili ngezibuyekezo nezithombe. I-Russian okulingana "Hart": izibuyekezo nezenhliziyo

Kwegazi - isishayo sabantu ezweni lanamuhla sika. Kunezici eziningana ezingezinhle zangaphandle, imvelo abampofu, ukucindezeleka njalo, kungabi nekudla lokondla umtimba futhi engaphumi njalo ukudala preconditions sokuthuthukiswa kwesifo senhliziyo ukubukeka yilesi sifo esesabekayo.

Modern Ikhemisi izama ukudala izidakamizwa ezinjalo, okungathi uma bengakwazanga ukuphulukisa umuntu umfutho ophezulu wegazi ngokuphelele, khona-ke okungenani, uzogcina blood pressure yakho ngaphansi kolawulo, kanjalo nokunciphisa ingozi isilethikusebenza nonhlangothi.

Okwamanje, ukufuneka kakhulu abathengi zisebenzisa lezi imithi antihypertensive ezifana "Hart", analogs lokhu izidakamizwa, eye yathuthuka kakhulu.

"Charter"

UMenzi "charter" zomuthi iyinkampani Hungarian EGIS Okwemithi PLC. Abathengi emithathu zalesi izidakamizwa, "Hart," "Hart D" no "Hart Amlo."

The main ingxenye esebenzayo ye "Charter" iyona ramipril izidakamizwa. I izinkomba eziyisisekelo eziseZwini Ukuze usebenzise lesi izidakamizwa e abantu kuba phambi izifo ezifana nomfutho wegazi ophezulu, nephropathy sikashukela, isifo sezinso, ehlasela umzimba egqoke ezingamahlalakhona. Ngaphezu kwalokho, "Charter" yokusetshenziswa (efanayo ezimweni eziningi futhi kuzonika nomphumela omuhle) uncoma ukunciphisa amathuba isilethikusebenza, "ukufa inhliziyo", ayiphulule kubantu abanegciwane nesifo senhliziyo nemithambo yayo (isifo senhliziyo). Futhi, umkhuba wokusebenzisa ukuqoka "charter" kulabo abahlushwa esingamahlalakhona senhliziyo ebuthaka e isigaba saso chronic esavela ngemva isiguli kudingeke ukuthi i infarction acute esivimba amanzi (imfuneko ukuze ukusebenzisa "Charter" - a imingcele hemodynamic ezinzile).

I nomuthi "Hart D" (analogs ngokuvumelana ezithinta ikhona) siqukethe izingxenye ezimbili asebenzayo - Ramipril futhi hydrochlorothiazide. Uphiko sokuqala kwehlisa umfutho wegazi ophezulu, ngaleyo ndlela sinciphise umthwalo phezu kwenhliziyo. Ingqikithi yesibili isisu, inkanuko inqubo ekususeni usawoti namanzi ngu nezinso iyafana ramipril igazi ephansi kwengcindezi. Ngakho, "Hart D" okunqunyiwe ukwelapha umfutho ophakeme wegazi lapho kuboniswe ukwelashwa eziyinkimbinkimbi nge ACE inhibitor, isisu kanye ejenti.

Izidakamizwa antihypertensive izidakamizwa "Hart Amlo" (ezifanayo Ukwakheka nethonya ekhemisi yesimanje etholakalayo) iqukethe izinto ezimbili eziyinhloko - ramipril futhi amlodipine. Inhloso yalesi izidakamizwa luqhutshwa ukwelapha umfutho ophakeme wegazi ezigulini abe ramipril kuqondane and amlodipine ngiyoba nethonya elihle bengabantu ngabanye isebenzise inhlanganisela yazo.

"Ramipril-C3"

Izidakamizwa "Ramipril-C3" - kuyinto Analogue of "Hart" eRussia. "Northern Star" itholakala eMoscow manje. The main isithako - ramipril. Njengoba asizayo aphume ashone magnesium stearate futhi monohydrate-lactose.

Imithi enqunyiwe abantu izifo ezifana nomfutho wegazi ophezulu, esingamahlalakhona senhliziyo ebuthaka (ifomu ezingamahlalakhona nokuthuthukisa ngemva acute isilethikusebenza).

In izifo imfuneko esinjalo aphoyintimenti "Ramiplila-C3" - hemodynamics esitebeleni. Kuyinto futhi inkomba ukuthatha amaphilisi Analogue "charter" yilona khona e ogulayo nephropathy sikashukela kanye non-sikashukela. Nge Kulindeleke yi ezinhle okunqunyiwe "Ramipril-C3" abantu ngemuva kokuhlinzwa ukuze transluminal angioplasty yenhliziyo futhi yenhliziyo Umthambo dlula ukuxhumelela (uma isifo esitebeleni nesineke nokuma).

Njengoba Izimo ngoba ethola nomuthi enze hypersensitivity ngabanye ukuba izingxenye samabanga aphansi noma lokulungisela umlando Imininingwane ngaphambilini sidluliselwe edema angioneurotic, cuphuluza izidakamizwa, ACE inhibitor. Contraindicated "Ramipril -C3" iziguli ezingaphansi kweminyaka engu-18 ubudala, ngoba alukho ulwazi ngokuphepha nokuphumelela kwaleso sembatho.

"Dilaprel"

izidakamizwa Antihypertensive "Dilaprel" uvezwa njengoMahluleli okulingana Russian of "Hart" emakethe ezithaka imithi. The main isithako - ramipril. Njengoba asizayo aphume ashone calcium stearate futhi colloidal Silicon dioxide.

Izinkomba ukusetshenziswa zomuthi: khona iziguli izifo ezifana nomfutho wegazi ophezulu kubalulekile, ukungakhuli umsebenzi inhliziyo esigabeni okungamahlalakhona (lihambisana namanye izidakamizwa, ikakhulukazi nge isisu).

Enquma imikhuba nephropathy (sikashukela, okungezona sikashukela), kuhlanganise lapho kuhlangene proteinuria, umfutho wegazi ophakeme. Dinga ukwamukela "Dilaprel" futhi kulezo zimo, lapho ngemva kwezinsuku ezimbalwa (izinsuku 2-9) Ngemva acute isilethikusebenza athuthukile ukuhluleka inhliziyo.

Imiphumela emihle banikwa imithi e kulezo ziguli kabani isimo sempilo libhekene okusezingeni eliphezulu ingozi zenhliziyo (ukuqala ngokuzumayo acute isilethikusebenza, unhlangothi).

Izisekelo ukuze ubhalise ukuthola analog ( "Hart" libhekene kakhulu le Izimo efanayo), kubhekwe umlando edema angioneurotic, hemodynamically abalulekile kwezinso Umthambo stenosis, stenosis of valve yomthambo i-aorta noma mitral, hypotension (umfutho ophansi wegazi), ukwehluleka umsebenzi so-renal kanye nesidingo isebenzisa umshini wezinso. reception engavumelekile "Dilaprela" iziguli ezine enganele umsebenzi inhliziyo e hronichesoy ifomu DEKOM esiteji ensatsii futhi khona nephropathy. Esigabeni acute yinhliziyo izidakamizwa akukashicilelwa ngoba angina engazinzile, inhliziyo yamaphaphu futhi sina ventricular arrhythmias inhliziyo.

"Vazolong"

Lokhu-analog ( "Hart" has okufanayo eziyisisekelo yokusebenza ingxenye - ramipril) has izimpawu ezilandelayo ukuze: nomfutho wegazi ophezulu (wegazi ophakeme, refractory, abulalayo, renovascular), nephropathy (sikashukela kanye asathuthuka e-zangokwasemuva zezinhlelo ezingamahlalakhona ngokukhukhumala kwentamo isifo so-renal).

It siba nomphumela cardioprotective futhi kakhulu ukunciphisa platelet wokuhlanganisa. I nomuthi ngcono ukuzwela kwezicubu insulin. ngemuva kwamahora umphumela Hypotensive kukhona eyodwa nengxenye ekutholeni nomuthi, umphumela esiphezulu kufinyelelwa ngemuva kwamahora 5-9 ukuchayeka isikhathi - amahora angu-24.

Kulaba contraindication ezinkulu ukusetshenziswa kwalesi izidakamizwa bungabonakala hypersensitivity kuya izingxenye (main nasizayo) le nomuthi noma kunoma iyiphi enye ACE inhibitor, khona ulwazi nomlando mayelana ngaphambili bafudukela edema angioneurotic, cuphuluza ukwelashwa nge-ACE inhibitor.

Lapho sokukhulelwa is contraindicated ukuthatha leli khambi, kanye "Charter". Yokusetshenziswa, yangempela (analogue of the "Charter", oqukethe ingxenye ramipril, alinakunikezwa kwabesifazane abakhulelwe), ochwepheshe bezempilo batusa i-ukwelashwa ukuqinisekisa ukungabi yokukhulelwa. Uma isiguli ukhulelwa ngesikhathi yokwelapha kumele isuswe ngokushesha izidakamizwa ramipril bese ukhetha iyiphi enye indlela yokwelashwa.

"Amprilan"

Ngo onjalo inhibitor ACE, njengoba "Amprilan", futhi fanekiso ukuba "charter", kokubili Ukwakheka kanye nomphumela. The main isithako of Medicine - ramipril. Ngo inkampani izingxenye aphume ashone sodium Bicarbonate, monohydrate lactose, sodium croscarmellose, isitashi.

Izinkomba ukusetshenziswa zomuthi ngokuvamile, icishe lifane nsé echazwe ngaphambilini "Vazolongu", "Dilaprelu" ramipril-C3 ": umfutho wegazi ophakeme, ezingamahlalakhona imisebenzi ukumelwa inhliziyo, nephropathy, ukunciphisa verooyatnosti ukuthuthukiswa zokugula senhliziyo.

Okubaliwe ka Izimo ukusetshenziswa kwalesi izidakamizwa ngempela ebanzi. "Amprilan" awupheli elibekelwe iziguli izifo ezibucayi ezifana kabili emaceleni kwezinso Umthambo stenosis endaweni stenosis hemodynamically abalulekile kwemithambo yegazi bese bakha izinso wodwa kanjani, imisebenzi esingamahlalakhona kwezinso, isimo ngemuva izinso ukufakelwa futhi isebenzisa umshini wezinso. Umuthi ayivunyelwe ukusebenzisa iziguli lezi zinkinga ezilandelayo inhliziyo: yomthambo i-aorta ne / nobe mitral stenosis, ezingamahlalakhona ukuhluleka inhliziyo (decompensation esiteji), zenhliziyo obstructive kanye nomfutho wegazi ophezulu.

umthamo Ingamukeleki imithi kwabesifazane ngesikhathi sokukhulelwa futhi ukuncelisa ingane. Contraindication engaphansi kweminyaka eyi-18.

"Ramikardiya"

Izidakamizwa analogue "charter" manje Friend ezithaka imithi emakethe ngokwanele ayegcwele. Enye Analogue owaziwa - "Ramikardiya". Izinkomba kanye contraindications imithi kukhona kucishe ngaxoxa "Amprilanom".

Ngaphambi kokuqala ukwelashwa nale ochwepheshe izidakamizwa batusa kakhulu ukuhlola isimo izinso, ngoba kuye isimo lezi zindikimba akhethiwe umthamo ngabanye ngoba impatho (noma izidakamizwa akazange enqabe). Phakathi ukwelashwa, leli thuluzi kucishe nomuthi "charter", yokusetshenziswa (analogue, cishe yonke ungase udale umonakalo omkhulu ezinsweni) Kunconywa ukulawula isimo uhlelo urinary, igazi electrolyte Ukwakheka, inani izinso enzyme neuropathy igazi isithombe.

Labo iziguli okukuyo uketshezi kusilela, sodium, ngaphambi kokuba uqale ukuthatha "Ramikardiyu", kubalulekile ukususa zonke amanzi electrolyte kwezinso. Phakathi ukwelashwa ngalo muthi engamukeleki ukuziphatha zelashwe usebenzisa Ulwelwesi lwamangqamuzana polyacrylonitrile, ngoba kunobungozi ukusabela anaphylactic.

"Ramigamma"

Yande analogue "Hart" eRussia. Enye izidakamizwa ezifana ibizwa ngokuthi "Ramigamma". The main isithako - ramipril. Izinkomba kanye contraindications zifana izimpawu izidakamizwa kuchaziwe ngenhla. Ukwelashwa nale ejenti kumele kwenziwe ngaphansi kokuqondisa udokotela ukuba khona.

Emva kokuthatha umthamo lokuqala "Ramigammy", noma ukwandisa umthamo isiguli ukuthatha isisu, ezako 8:00 kaningi ngangokunokwenzeka kuyadingeka ukukala blood pressure. Lokhu kuyadingeka ukuze ekunqandeni futhi okusheshayo ukuphendula hypotensive (bebek blood pressure). Ukunakwa zidinga iziguli sina isifo sezinso futhi yisimiso senhliziyo nemithambo yegazi.

Phakathi ukwelashwa kubalulekile ukulawula ezingeni amangqamuzana amhlophe egazi, ukuze singathwesi miss isikhashana leucopenia.

"Hart" analogs zomuthi (kuhlanganise "Remigammu") akufanele iqondiswa iziguli okwamanje wanika desensitizing ukwelashwa (ukwehlisa komzimba nezinto ukulunywa yizinambuzane). Okuhambisanayo ACE inhibitor namanxusa niqaphelisa kungabangela ukuthuthukiswa okukhulu, (nokuvaleka kwemigudu yokuphefumula, ukwehla komfutho wegazi, ukuhlanza, njll) ezisongela ukuphila anaphylactic ukusabela komzimba

"Kardipril"

Hedgehog eyodwa izidakamizwa sasivumela owaziwa - i Analogue of "Hart" - "Kardipril". ingxenye Active - ramipril. I izinkomba esiyinhloko ukusetshenziswa kwezidakamizwa - umfutho wegazi ophakeme, congestive senhliziyo (njengoba ingxenye ukwelapha ngenhlanganisela), nephropathy (isigaba saso sokuqala kanye), esingamahlalakhona senhliziyo ebuthaka ngemva isilethikusebenza.

Izimo ukusetshenziswa "Kardiprila" ngempela ebanzi. Imithi akufanele ebekiwe ukwamukela khona kwezinso nesibindi ukwehluleka, omzimba izicubu erythematosus, kwezinso Umthambo stenosis, nge hyperkalemia futhi hyponatremia, ukucindezelwa umnkantsha hematopoiesis. Musa linqume izidakamizwa ngesikhathi sokukhulelwa, lactation futhi kwezinye iziguli ezingaphansi kweminyaka engu-18 ubudala.

Nge ukweqisa izidakamizwa of "Kardiprilom" angagcina hypotension okukhulu (iconsi wegazi), ukungasebenzi kwezinso, ezinzima electrolyte kwezinso, ukushaqeka. Ukuqeda imiphumela idingekile ukuze ukuqapha okuqhubekayo kanye nokwesekwa ozolandela imisebenzi eyisisekelo. Uma enamandla ingcindezi amathonsi ingasatshenziswa isamba esengeziwe sika-sodium ne eziwuketshezi. Hemodialysis iyiphi nomthelela obonakalayo ngeke unike.

"Tritatse"

Yini enye engingabuye analogu ka "Hart"? Enye iziguli isidakamizwa esaziwa kanti esetshenziswa kabanzi - "Tritatse". Imithi itholakala kweJalimane neFrance. The main isithako - ramipril. Izinkomba isicelo, kodwa-ke, njengoba, kanye contraindications cishe efanayo nabo bonke umthamo echazwe ngaphambilini kusho ACE-inhibitor. Ukwelashwa nge "Tritatse" ngokuvamile okuthatha isikhathi eside, okuyinto esimweni ngasinye kunqunywa udokotela ukuba khona.

Ngaphambi kokuba uqale ukwelashwa nale imithi, kubalulekile ukuqinisekisa ukungabi khona izimo ezifana hyponatremia futhi hypovolemia. Esimweni lapho isiguli kwake wathola noma yimuphi umuthi, isisu, banayo ukukhansela noma okungenani banciphise umthamo wabo izinsuku 2-3 ngaphambi Ukuqalwa ukwelashwa nokusetshenziswa "Tritatse".

Emva komthamo wokuqala, noma ukwanda isisu izisebenzi zezokwelapha kumele ngempela ukunikeza ngokucophelela ukuqapha isiguli okungenani amahora angu-8. Lokhu kuyadingeka ukuze athathe izinyathelo ezifanele ngokuwa lishesha kakhulu wegazi.

Uma isiguli sine ukuhluleka kwenhliziyo noma amafomu abulalayo nomfutho wegazi ophezulu, ukwelashwa nge "Tritatse" bavunyelwe ukuqala kuphela esibhedlela.

Phakathi naso sonke isikhathi sokwelashwa nale imithi kufanele iqaphe umsebenzi kwezinso, lizinga lokuhlushwa electrolyte, Hematology (i-hemoglobin, platelet count, leucocytes, erythrocyte, leukocyte ifomula).

umbono Isazi phezu ACE

Kunjani yimuphi umkhiqizo sina kwezokwelapha lapho kungenzeka zihlanganisa "charter" futhi engcono analogue yakhe Izibuyekezo wenhliziyo, udokotela yanoma yisiphi esinye lunye noma isiguli angashiya izinkomba okuhle nokubi.

Iziguli eziningi azichaza "Hart" futhi iningi ontanga yayo njengendlela izidakamizwa fast kakhulu-ukwenza, ngempumelelo ngisho at eliphezulu kakhulu umfutho wegazi. Isikhathi ukuchayeka izidakamizwa yaleli qembu futhi ifinyelela amahora 24. Nakuba amanani wale mikhiqizo ziyahlukahluka kakhulu, futhi akubona bonke izidakamizwa ayatholakala anhlobonhlobo abathengi.

Nokho, Kunemibono ezingezinhle mayelana izidakamizwa "Hart". Analogs libuyekeza iziguli ngezinye izikhathi uchaze ohlangothini ezimbi. Isizathu siwukuthi zonke lezi amakhambi kungabangela ukuthuthukiswa lonke bunch of izigameko ezingezinhle ezavela, ezinye zazo ngempela ezisindayo. Kule ndaba, ochwepheshe bezokwelapha azwelane iziguli zabo. Nakuba iningi bezempilo bakholelwa ukuthi imithi enjalo baye kwasindisa izimpilo, futhi zibalulekile kakhulu abantu. Into esemqoka akukona ukuthi akwabele ngokwakho ezingeni zokuzelapha, futhi banamathela isincomo udokotela ukuba khona.