Yokusetshenziswa "tiapridal". Analogs kanye nokubuyekeza

"Tiapridal" - imithi antipsychotic oluqanjwe tiapride. Umuthi sisetshenziswa njengomlaliso, sine-analgesic kanye okuyiluthayo. Isisekelo isinyathelo antipsychotic - ekuvimbeni receptor Dopamine, okuyinto kakhulu kuthinta ukusebenza CNS. Kulesi sihloko sichaza ngokuningiliziwe mayelana izidakamizwa.

Ukwakheka anabamemezeli izidakamizwa

Umuthi itholakala amafomu amabili, ithebhulethi angathengwa futhi isixazululo:

• Omunye ithebhulethi njengenye ampoule yakhiwa angu-100 Isakhi esiyinhloko kanye izinto asizayo. Njengoba izithako asizayo elisetshenziswa ukubunjwa povidone, magnesium stearate, mannitol. Ukwakheka nayo kulekelelwa i aqueous dioxide colloidal, Silicon kanye microcrystalline cellulose.
• Ngaphandle nje kokuthi Isakhi esiyinhloko isixazululo yakhiwa sodium chloride namanzi umjovo.

Kokunye ibhokisi equkethwe amaphilisi 20 (2 amabhamuza amaphilisi 10) noma izitsha eziyisikhombisa 12 (2 amabhamuza ka 6 izitsha eziyisikhombisa). Yokusetshenziswa "Tiapridal" ngesimo isixazululo umjovo ivumela iqondiswa ngemithambo yegazi futhi intramuscularly. Le ndlela umuthi kuphela ezifanelekela nokwelashwa kweziguli omdala.

Pharmacodynamics "tiapridal"

I nomuthi has neuroleptic, analgesic kanye isinyathelo anxiolytic. Njengoba bhukwana imfundo, "Tiapridal" ngokukhetha amabhlogo ukusebenza D ₂ receptor ka Dopamine emaphakathi. Ngakho ku D ₁ receptor akunamthelela. Umuthi kuqeda psoriasis, lapho lusetshenziswa kwasebekhulile ngcono ukucabanga.

Pharmacokinetics "tiapridal"

ekuphathweni esicutshini zomuthi (200 mg) zezinga walo omkhulu emzimbeni itholwa ngemva kwemizuzu engu-30, usebenzisa i-izibhebhe at umthamo ofanayo - imizuzu 60. I bioavailability zomuthi uma kusetshenziselwa ngokushesha ngaphambi kokudla nge 75% anda ukuze 95%. Ngenxa izidakamizwa ezifana ukusetshenziswa ukwanda kanye level yayo esiphezulu ku i umzimba (40%).

Absorption emzimbeni kancane ezigulini esezikhulile. "Tiapridal" yokusetshenziswa libhekisela umenzeli kweqa esinomhlapho futhi gazi ebuchosheni izithiyo. Kuyaziwa ukuthi phakathi impatho izidakamizwa elikhona ukubunjwa ubisi lwebele ezaziwayo. Ngo abesifazane, ukususwa ngokwengxenye zomuthi ngokushesha kunokuba ukuthi abantu (ngaphezu kumahora angu-2.9), umehluko amahora 0.7. Umzimba kwachazwa ngokuthi ngokulinganisela. Ingxenye eyinhloko izidakamizwa (70%) esuswa umzimba by izinso zinjalo.

Izinkomba "Tiapridal" ukulungiselela

Ukuqalisa imishanguzo nezidakamizwa "Tiapridal" Ukufundwa kanje:

• dyskinesia (tardive ukuxoxa);
• Gilles de la Tourette syndrome;
• chorea;
• ezibangela ukuziphatha okuyinqaba (isimo nolaka, ukuyaluza et al.), okuholela ukugeleza eningi kabi kotshwala chronic ezigulini esezikhulile;
• ukubonakaliswa emibi yokuziphatha, ezifana isimo nolaka nokuyaluza;
• ubuhlungu uhlamvu olunzulu (ifomu zezifo ezingelapheki).

Izimo, ukulinganiselwa ukuthola "Tiapridal" izidakamizwa

Unqabela ukunqunywa "Tiapridal" yokusetshenziswa izingane zabo iminyaka yobudala engaphansi kuka iminyaka eyisithupha. Therapy ezingane Kwenziwa amaphilisi kuphela. Umuthi akufanele aphathwe abesifazane abakhulelwe kanye iziguli ibele. Imithi alisetshenziswa uma hypersensitivity kuya izingxenye zalo, kanye nezinye izindlela ezinjalo. Izimo zihlanganisa uthi ezifana:

• hepatic futhi ukwehluleka kwezinso, esesikhundleni kobukhulu eside;
• prolaktinzavisimogo ekuxilongweni izimila, izinsolo khona layo;
• Inkinga abanomfutho wegazi ophakeme;
• ukuxilongwa pheochromocytoma, izinsolo ukhona.

Tablets kanye nekhambi isetshenziswa kanye "sultopride" futhi Dopamine yokwamukela agonists (ngaphandle iyona nokwelashwa kweziguli Parkinson) kungukuthi kuhlanganiswe nezinhlobo ezithile neuroleptics, amanxusa anti-arrhythmic okuqondene amakilasi mina III A.

Uthobe "Tiapridal" imfundo ayikuvumeli kanyekanye usebenzisa "moxifloxacin", "sparfloxacin", "Difemanila", "Erythromycin", "bepridil," "mizolastine", "levodopa", "cisapride" futhi emthanjeni "vincamine" .

Uma isiguli (ikakhulukazi asebekhulile) ukuphathwa izidakamizwa angaholela ekuthuthukisweni hypokalemia, inhliziyo conduction uwohloke ayewukela isikhawu qt, okuvela kuyo bradycardia uzwakalise uhlamvu, sebenzisa "Tiapridal" kumelwe ngokucophelela. Isexwayiso liyadingeka ezimweni ezinjalo:

• Parkinson;
• azalwa naso qt isikhawu ukunwebeka uhlamvu;
• hypokalemia;
• ezingamahlalakhona ukwehluleka kwezinso;
• bradycardia;
• izifo lapho kwaphazamisa esimiso senhliziyo nemithambo yegazi (decompensation isinyathelo);
• isithuthwane.

Ukwelashwa nge "Tiapridal"

on isicelo "Tiapridal" manual incoma usebenzisa lokuqala ngemithamo emincane, kancane kancane zandise izinto kubo, ukuze bathole umphumela esiphezulu.

ezibangela ukuziphatha okuyinqaba

Ukuze impumuzo yabo kubalulekile ukusebenzisa 200 mg zomuthi nsuku zonke (kufika ku-300). Umphumela omuhle kufinyelelwa emasontweni ayisithupha ngokwesilinganiso. iziguli esezikhulile iqondiswa umthamo engezansi imithi - 50 mg. A umthamo owodwa ziphele kabili ngosuku, futhi izithelo zawo kuvunyelwe kuhambisana isikhawu eshiwo, isenzo wenziwa kancane kancane, kubhekelwa uchwepheshe akhawunti iseluleko. I umthamo wansuku zonke kumele singeqi mg 300.

ubuhlungu obungapheli okukhulu

I umthamo wansuku zonke zomuthi ukwelashwa kwezimo ezinjalo kuba ngu-200 kuya ku-400 mg.

Chorea, Gilles de la Tourette syndrome

Lapho efeza umsebenzi ekwelapheni ingane umthamo wansuku zonke kuyakhethwa kucatshangelwa isisindo emzimbeni futhi mayelana 3-6 mg / kg. Uma udinga ukuqhuba yokwelapha omdala, aqala ukusetshenziswa 25 mg zomuthi ngelanga, kamuva (ngemva ukwenyuka kancane umthamo) - 300-800 mg.

Ukuyaluza, ubudlova

I Kunconywa umthamo zonke izinsuku we nomuthi ivela 100 kuya ku-150 mg.

ezibangela ukuziphatha okuyinqaba

Umthamo watusa nemibhede ukusetshenziswa (200 kuya ku-300 mg) esimweni uthi delirious noma predelirioznogo antante 400-1200 mg. Umkhawulo kungenzeka umthamo okuyinto akumele lidlule, kuyinto 1800 mg. Ukwethulwa kwe izidakamizwa akhiqizwa cishe njalo ezinhlanu amahora. Uma impatho kuyadingeka ukuze umuntu osekhulile, zonke izinsuku 2-3 imijovo phakathi okuyinto waphawula isikhawu amahora 6. Ukuze nokwelashwa kweziguli ezifana Kunconywa engayitholi nsuku zonke mg 200 kuya 300 nomuthi ngesikhathi uvunyelwe ukungena ngaphansi kuka-100 mg "tiapridal".

Inkulumo Olukhulu bemvelo njalo ubuhlungu

Engamakhambi esekelwe iqondiswa umthamo nsuku zonke elihambisana 200-400 mg zomuthi.

Imiphumela engemihle uma nithatha "Tiapridal" izidakamizwa

Lapho nokwelapha izidakamizwa "Tiapridal" imfundo manual, ukubuyekezwa ukuqinisekisa amathuba ukusabela ezithile ezingezinhle. Ukwephulwa kungenzeka urogenital, abakaze, endocrine kanye izinhlelo zenhliziyo. Ngaphezu kwalokho, kukhona ingozi izinkinga izinzwa. Ukuze uthole ezinye imiphumela emibi zihlanganisa komzimba, isikhumba ukubonakaliswa ephelezelwa kwesisindo hypotension orthostatic.

Overdose "tiapridal"

Uma usebenzisa umthamo ngokweqile kungenzeka ukweqisa izidakamizwa futhi izimpawu zaso zihlanganisa thuthuva ukwazi, okusemqoka kakhulu zazo - ikhoma, syndrome neuroleptic (abulalayo, amafomu acute). Ukuze ukulungisa lokhu isimo umzimba Kwenziwa ngelashwa ejenti anticholinergic. Ngemva ukuqedwa adingekayo izidakamizwa lokufeza ukwelashwa lingaze futhi plasmapheresis.

Izixwayiso

Ngaphambi ukusetshenziswa umuthi "Tiapridal" imfundo manual incoma ukuthi ulungise hypokalemia. Phakathi ukwelashwa kubalulekile sihlale njalo siqaphele electrolyte ibhalansi, aqhube electrocardiogram, ukuqapha lwasemtholampilo izinguquko isithombe.

Uma kubalulekile ukusebenzisa anticholinergic izidakamizwa umphumela ethola neuroleptics syndrome extrapyramidal ithuthukiswe esikhundleni Dopamine yokwamukela agonist.

Ngesikhathi sokwelashwa kufanele uhlukane nale imisebenzi ezibeka ibe usongo, it is hhayi Kunconywa ukuba enze umsebenzi odinga ukunakekelwa okukhethekile futhi impendulo esheshayo.

Ukuxhumana nezinye izinto

Ezinye amalungiselelo lihambisana ukuphuza umuthi "Tiapridal" imfundo, impendulo elihlobene ne ematfuba nesenzakalo ukusabela kwalo. It is hhayi Kunconywa ngesikhatsi ukwelashwa isicelo "Clonidine", antihistamine, anxiolytics, barbiturates futhi opioids, njengoba "tiapridal" umphumela kuyoba evelele. Ngenxa ukungavumelani akufanele kuthathwe "levodopa" kanye notshwala. Imithi kungenziwa kuhlangene nokusetshenziswa neurotrophic izidakamizwa, analgesics, imithi yokucindezeleka nezidambisa neuroleptics. ingozi Ephakeme hypotension orthostatic, kukhona ukusetshenziswa ngesikhathi esisodwa izidakamizwa antihypertensive nge "Tiapridalom".

Izindleko izidakamizwa analogue, izibuyekezo mayelana izidakamizwa "Tiapridal"

Uma impatho kunesidingo "Tiapridal" kusho incazelo imfundo ukukwazisa lokho umuthi. Intengo izidakamizwa kubaluleke kakhulu e ukukhethwa nomuthi ukuze bayothola ukwelashwa. Isixazululo ku izitsha eziyisikhombisa zingathengwa for ruble mayelana 995, kanye amaphilisi - I-ruble 1,400.

Phakathi analogue zomuthi - "Eglonil", "Betamax". Kulaba esikhundleni kungase kukhethwe "Sulpiride" noma "Prosulpin". Kunenye Analogue zomuthi - "tiaprid", lapho kubhekwa kulula kakhulu ukufinyelela kuwo, kunzima kakhulu kukho adumile, production ezifuywayo izidakamizwa elibhekene nomse- inkampani "Organic". Njengengxenye 'tiaprid "ukwethula athi unesimo esifana asebenzayo, oyingxenye ye imithi" Tiapridal ". Ukusetshenziswa analogs Guide uncoma ukukhetha, lapho yasekuqaleni ayikwazi ukusetshenziswa kanyekanye nabanye izidakamizwa kubangela imiphumela emibi bese akayinekezi umphumela oyifunayo. Ukuze izidakamizwa kwaphumelela kakhulu, acabangele eziningi amaphuzu uma ekhethiwe.

Phakathi ukwelashwa, kubalulekile ukulandela iseluleko zonke udokotela kanye nezincomo, equkethe yokusetshenziswa. "Tiapridal", njengoba kuboniswa umbiko, ezimweni eziningi, isetshenziselwa ukuqeda izimo ephelezelwa injabulo kwemizwa nokuziphatha nolaka sengqondo oludakayo. Ngokuvamile, iziguli kanye nodokotela weneliseka yi yokwelapha. Ngokuyinhloko, yizifundo zokuvuselela ayidingekile ngenxa yokuthi umphumela oyifunayo ethuthuka emva ukuqaliswa inkambo lokuqala. Izibuyekezo ukukhombisa ukuthi iziguli imithi "Tiapridal" kulula ukuyisebenzisa.