Umuthi 'Sultasin ": yokusetshenziswa

"Sultasin" - i-antibiotic okungokukaNkulunkulu iqembu i-penicillin. Njengengxenye samanje beta-lactamase inhibitor. Ukuze amagciwane amaningi engazweli bucayi, yenzelwe ukusetshenziswa avamile.

Ngayiphi yefomu izidakamizwa ikhishwe, elikhona ngezithako zawo?

Umuthi itholakala powder. Yilesi isisekelo ngokudala isixazululo okwenziwé usebenzisa umjovo. Esikhathini ibhodlela kungenzeka amanani angalingani powder - 0.75 noma 1.5 g izithako ezisebenzayo esetshenziswa ifomu sodium nosawoti Ukwakheka likhona isithako ezimbili eziyinhloko - sulbactam futhi ampicillin, ngasinye sazo eziqukethwe ibhodlela 250 kanye 500 mg.

isenzo izidakamizwa

"Sultasin" afundiswe akubonisayo njengoba imithi elwa namagciwane amagciwane amelana acid. Umuthi kuvimbela synthesis peptidoglycan, ukuze odongeni cell microorganism musa ukuthuthukisa.

Ampicillin siphathelene-antibiotic semisynthetic, it has a isinyathelo amagciwane, kuphazamisa kumiswa iseli izindonga kwamagciwane, ukubuyabuyelela ngakhoke iqhubeke microorganism ingekho. Ampicillin lingabulewe ngenxa yesenzo acid.

Sulbactam kuyinto inhibitor beta-lactamase, isenzo elwa namagciwane ayinakho amathonya ku namagciwane amelana we-beta-lactamase. Umuthi isetshenziswa ukwelapha izimo kubangelwa anaerobic bacterium, Gram-negative nezinto eziphilayo Gram-HIV, kuba okudiliza ezinye yohlobo lwazo. Lapho wadalula kwamagciwane musa ukukhiqiza ukukhiqizwa beta-lactamase, umsebenzi izidakamizwa "Sultasin" yokusetshenziswa kulingana isenzo ezilethwa ampicillin eyodwa kuphela.

Pharmacokinetics

Umuthi itholwa emva isicelo cishe kuzo zonke izinto eziwuketshezi nezicubu zomzimba womuntu. Ephambi kwezinduna izinqubo ukuvuvukala permeability zomuthi kakhulu anda esikhathini cerebrospinal fluid.

Ukwethulwa nomuthi izinto esicutshini futhi emthanjeni asebenzayo ekhona igazi e lokuhlala eliphezulu. ukuqedwa kwengxenye zomuthi Kwenziwa ngehora elilodwa. kususwe emzimbeni by izinso Kwenziwa, iningi Sultasin amanxusa ' "(70 kuya ku-80%) has a ijamo esinqunyiwe. Futhi ingxenye excretion zomuthi eyalo isibindi. Umuthi itholakala ubisi lwebele uma ungalawulwa, uphazamise umngcele isithiyo esinomhlapho. Izingxenye ezisemqoka yilezi umzimba okuncane, mayelana 25% "Sultasina" isehlane njengoba metabolites.

ubufakazi

Izidakamizwa "Sultasin" imfundo manual uncoma ukuthi usebenzise kulezi uthi:

• ukutheleleka ezithinta elingenhla izitho zokuphefumula kanye umgudu wokuphefumula;
• meningitis;
• izinqubo ezithathelwanayo lapho emalungeni ethintekile namathambo;
• sepsis;
• i-shock syndrome futhi ipheshana biliary ezibangelwa amagciwane;
• peritonitis;
• Izilonda, izilonda kwezicubu ezithambile;
• endocarditis webhaktheriya;
• emagciwaneni, kuthinta sangasese ngomgudu womchamo;
• Gonococcal inqubo ukutheleleka;
• scarlet fever.

Futhi, kwezidakamizwa izinyathelo okuhloswe ngazo zokuvimbela izinkinga nasezinkingeni ezilandela ngemva kokuhlinzwa. Umuthi elisetshenziswa izinqubo ezithathelwanayo okuyinto lwegciwane - bacterium nozwelo, futhi ukuvimbela ukuthuthukiswa izinqubo negative, kulandela ukugasela kuhlinzwa, lapho manipulations kudingekile yayidlalwa ukhalo nezitho besisu.

Izimo

"Sultasin" yokusetshenziswa ayikuvumeli ukusetshenziswa e mononucleosis ezithathelwanayo, hypersensitivity kanye lactation.

Uma usebenzisa abesifazane abakhulelwe ukulungiselela kudinga ukunakekelwa okukhethekile, kanye kule nokwelashwa kweziguli esingamahlalakhona kwezinso noma hepatic.

Isikali ukwelashwa izidakamizwa uyisebenzisa

I nomuthi iqondiswa izindlela emthanjeni futhi esicutshini. Ukuphatha i-ejenti kumele kwenziwe kancane. Ukuze ukusetshenziswa emthanjeni, ukuphathwa Kwenziwa izinsuku eziyisihlanu kuya kweziyisikhombisa. Uma kukhona isidingo nokuqhuba ukwelashwa eyengeziwe, ngemuva kwalokhu ikhambi saphathwa intramuscularly.

Isilinganiso izinto asebenzayo - ampicillin futhi sulbactam - 2: 1. Uma inqubo ezithathelwanayo lichazwa ngokuthi ukukhanya kudingeka umthamo ukuba basukela 1.5 kuya ku-3 amagremu iqondiswa sokuhlukanisa ku izikhathi ezimbili ukulungiselela "Sultasin". Yokusetshenziswa imijovo i-kobukhulu isilinganiso ukugula incoma ukwenza kathathu noma kane, futhi ngosuku kufanele ingasetshenziswa kusukela 3 kuya ku-6 amagremu zomuthi. Sinzima ukutheleleka nqubo idinga ukwethulwa 12 g we nomuthi nge imvamisa efanayo njengoba kwaba njalo endabeni odlule.

Lapho isipatsholo ayinakho yezinkinga nomuthi ngokwanele 1.5g elawulwa esisodwa. Izinsana, ubudala esingeqile iviki elilodwa, kanye labantwana usemncane, iphathwa nge esingaba ngamahora angu-12, ikhambi "Sultasin". Imiyalelo ukusetshenziswa nezingane bakhuthazwa ukuba baphakamise 150 mg izidakamizwa ngalinye kilogram of isisindo sengane ngayinye. Lokhu umthamo wansuku zonke okuyindawo ehlanganisa sulbactam futhi ampicillin at 100 no-50 mg / kg, ngokulandelana. Phakathi ukwelashwa, umthamo ezifanele zomuthi zaphathwa ingane nsuku zonke izikhathi ezintathu noma ezine.

Nokuvinjelwa yezinkinga Ochwepheshe isicelo 1.5-3 g zomuthi ngesikhathi izinzwa, kamuva (ngaphakathi ngelinye ilanga emva kokuhlinzwa) usebenzisa okufanayo umthamo izindlela, kodwa hhayi kanye, kodwa ngezikhathi amahora 6-8.

Ukwelashwa kuthatha cishe ezinhlanu izinsuku eziyishumi nane. Lapho zonke izimpawu abantu abaye balahlekelwa umsebenzi, futhi izinga lokushisa komzimba kungokwemvelo, ukuphathwa ekhiqizwa ngisho izinsuku ezimbili.

Lingandile nomuthi esasikhipha "Sultasin" imfundo manual khulumela nokwehluleka ukusebenza kwezinso, okwenzeka ifomu ezingamahlalakhona lapho imvume 30 ml / imiz.

Ukulungiselela yesixazululo

Uma uhlela ukuba abaphathi parenteral ka ikhambi izidakamizwa ngokushesha ngemva ukulungiselela iqondiswa esigulini. Uma "Sultasin" kufanele sinikezwe intramuscularly, powder buhlanjululwe ngamanzi ngoba umjovo i inani 2 (isitsha ezincane) noma 4 ml (isitsha equkethe 1.5 g ejenti ezomile), kuye ngokuthi inani powder. Ungasebenzisa isixazululo ezahlukene. Okukushoyo umjovo ukulungiselela uchwepheshe, ngoba nguye kuphela uzokwazi ukwenza lesifanele kakhulu.

Ukulungiselela yesixazululo e umthamo owodwa adingekayo ukuphatha ngemithambo yegazi, kudinga ukusetshenziswa sodium chloride noma 5% glucose.

side effects

Oyinikezwe "Sultasin"? Yokusetshenziswa, ukubuyekezwa uthi ingozi ukusabela ezingezinhle komzimba ezinye izinhlelo zawo ezifana wokugaya ukudla, isimiso sezinzwa esiyinhloko. ukuphazamiseka kungenzeka ukusebenza igazi, kungenzeka komzimba futhi ukushintsha ezinye nemingcele laboratory. Ezinye iziguli sithola ukusabela lendawo lapho zaphathwa ngemithambo yegazi - phlebitis, usebenzisa enye indlela yokuphathwa - soreness kusayithi umjovo. Phakathi nokunye ukuhlukumezwa - nemiphumela kubangelwa yokwelapha eside (candidiasis, superinfection).

ukweqisa izidakamizwa

ebulilini zomuthi kungaholela Ukudlikizela nabanesithuthwane, ukuqeda ezidinga ukususwa zomuthi nokusetshenziswa laxatives emanzini-electrolyte Okusele ezingeni elifanele kanye therapy okunezimpawu.

Izixwayiso

Kufanele ukujwayelana "Sultasin" ukulungiselela (yokusetshenziswa, incazelo) labo abanemizimba komzimba nezinto, njengoba uma kuhlangene le antibiotic cephalosporin futhi hypersensitivity penicillin kukhona ingozi yokusabela cross-nomzimba.

Inkambo yokwelashwa kudinga njalo isimo zokuqapha kwezinso futhi ukusebenza hematopoiesis isibindi. Ezimweni lapho kwakukhona nokwanda kokungabi microflora ukukhula, nokuzwelana izidakamizwa, isiguli singase sithole khona superinfection. Kulezi zimo, izinguquko ezidingekayo iphathwa ku lwemithi.

Phakathi ukwelashwa of sepsis bacteriolysis ukusabela kungenzeka. On kungenzeka ngokuhlanganisa "Sultasina" nezinye izidakamizwa kufanele kube ukufunda kusukela uchwepheshe.

Izibuyekezo Analogs

Uma ungenalo evumela ukusetshenziswa "imiyalelo Sultasin 'ukusetshenziswa, analogs, ezifana izidakamizwa" unazin ", okuyinto esikhundleni ketshezi asebenzayo," Sulbatsin "," Sulatsillin "futhi" Ampisid "ukhetha udokotela ukuba khona, ucabangela isimo sempilo isiguli. Ngezinye izikhathi Analogue bayazuza okungaphezu yokuqala, njengoba ekahle isiguli futhi oluhambisana izici lomzimba wakhe.

Amakhasimende weneliseka inani lentengo lomuthi, kodwa abaningi bayesaba inqwaba ukusabela ezingezinhle. Njengoba nokubuyekezwa, ezimweni lapho izidakamizwa ibilokhu isetshenziswa abesifazane ngesikhathi sokukhulelwa, nomthelela omubi esimweni kwakungelona impilo yengane. Ezinye iziguli samanje ezincane ukusabela ezingezinhle. Lokho babengakwazi ababekubikezela noma ababekubhala basho kancane, ukwelashwa okufanele "Sultasin" izindlela lufanele lwenteke kulamazinga lalandzelako. Yokusetshenziswa izingane ivumela ukwelashwa ngalo muthi, kodwa-ke, ukwahlulela nge ukubuyekezwa, kwezinye izimo, yezinkinga ezinzima zenzeka, kukhona okukhulu side effects, kuba dolechivatsya kudingekile ngezinye izindlela.