Umuthi 'Menopur ": ukubuyekezwa kanye imiphumela, yokusetshenziswa kanye nencazelo

Abaningana impela imibhangqwana abaphethwe nenzalo. imithi yesimanje isethubeni elikhulu ekuxazululeni le nkinga, kodwa zonke iziguli kufanele uqaphele ukuthi imishanguzo kufanele isikhathi eside. "Menopur" - umuthi liyasetshenziswa ekwelapheni ukungabi nenzalo. Le ndatshana izozama ukuze aqonde ukuthi yini lo mshini wezenzo nokubonakaliswa ukusetshenziswa lapho anakho.

Khipha ifomu kanye nokwakheka izidakamizwa "Menopur"

Izindlela etholakala amaphilisi.

Ukwakheka: ikhemikhali eyisisekelo - follicle inkanuko i-hormone (FSH) kanye luteinizing i-hormone (LH) ku isilinganiso 1: 1.

izingxenye engeziwe:

• monohydrate lactose.
• Polysorbate 20.
• sodium hydroxide.
• Hydrochloric acid.

Futhi ezifakwe umuthi kuyinto ampoule nge kuphela equkethe i solution isotonic of sodium chloride futhi alulaze hydrochloric acid ukwakha pH ezingeni evamile.

izidakamizwa Itholakala ngaphatha ibhokisi elinezincwadi, kanti lokhu kuhambisana 5 ngemithi izitsha eziyisikhombisa futhi 5 - ne kuphela.

Njengengxenye izidakamizwa "Menopur" iqukethe yokuhlanza ekhethekile menopausal womuntu gonadotropin. Lisuselwa umchamo Engxenyeni zesifazane lwesintu, ngemva kokuba kudlule nambili kuya kwabadala. Lapho zaphathwa owesifazane "Menopur" izidakamizwa (ukubuyekezwa kanye imiphumela eminingi izifundo ubufakazi) ukuthi kushukumisa zokukhiqiza i-estrogen kanye nokuvuthwa of follicle. Ngaphezu kwalokho, izinqubo proliferative okwenzeka endometrium.

Uma sethula izidakamizwa kulowo muntu, it kwandisa izinga kwe-testosterone emzimbeni wakhe. Futhi izidakamizwa kuvusa spermatogenesis, ngenxa umphumela amaseli tubules seminiferous.

"Menopur": izinkomba ukusetshenziswa

Abesifazane belulekwa ukuba uthathe isidakamizwa for ukungazali kubangelwa iziyaluyalu hypothalamic-pituitary kanye ukuqaliswa ubuchwepheshe eyengeziwe zokuzala ukuze ukukhulelwa okuhlaselayo.

Abesilisa nabo belulekwa ukuba usebenzise "Menopur". Izibuyekezo kanye nemiphumela yokwelashwa ukuqinisekisa ukusebenza yayo I-azoospermia futhi oligoastenospermii, okuyizinto ngenxa samabanga aphansi noma hypogonadotropic hypogonadism, kodwa izidakamizwa kuphela ukuba kuhlanganiswe nomunye gonadotropin izidakamizwa chorionic womuntu - hCG.

"Menopur": yokwamukela esifanele abesifazane

Abesifazane izidakamizwa Kunconywa ukuba ibhekane inkambo umjovo ukungazali, okuyinto abangela izinkinga ezindaweni zobuchopho obhekene ekukhiqizweni kwama-hormone zesifazane. Isizathu salokhu siwukuthi yonke Isikali owesifazane kushintshwe ngamunye. Inani elikhulu zomuthi kanye therapy Yiqiniso setha kuphela emva zonke izifundo:

• Ultrasound ezikhiqiza amaqanda.
• Icacisa izinga lama-hormone yesifazane umthamo wegazi lesiguli.
• Zonke izivivinyo kunesidingo.
• Ingxoxo ne udokotela.

Umsuka esasikhipha "Menopur" ukulungiselela (libuyekeza ubufakazi kwemiphumela ukwelashwa) nge 1-2 izitsha eziyisikhombisa ngelanga (75-150 IU). Uma amaqanda ungaphenduli, umthamo kumele kancane kancane ukuze nje amazinga estrogen ngeke kukhuphule izinga lokuthi ngokukhula kwezinhlelo follicle. Ngemva kwalokho, umthamo ukuhlala kuleli zinga kuze kube amazinga egazi estrogen ngeke efanayo nge-ovulation. Uma ezingeni estrogen liphuma ngokushesha, ukunciphisa umthamo.

Ukuze ntombazane ukukhiqizwa kwamaqanda ngosuku, okungenani, ezimbili emva umjovo zokugcina "Menopur" singly iqondiswa 5 000-10 000 IU hCG.

"Menopur" ngoba nengxenye enamandla lesintu

"Menopur" ngoba amadoda (ukubuyekezwa kanye ukusetshenziswa imiphumela ukusekela lokhu) Kunconywa ezishukumisayo inqubo kumiswa spermatozoa. Qondisa izidakamizwa ingcosana 1 000-3 000 IU hCG kathathu ngesonto kuze ukuzinza amazinga testosterone egazini.

Ngemva kwalokho, izidakamizwa kumelwe futhi ukubhalisela emzimbeni wesilisa katsatfu ngeliviki, kodwa inani 1-2 izitsha eziyisikhombisa (75-150 IU) ezinyangeni ezimbalwa.

Izimo

"Menopur" - umuthi omuhle kakhulu, kodwa-ke has Izimo yayo ukusetshenziswa lapho isiguli ngasinye ngaphambi kokuqala ukwelashwa kufanele mangiye ukuba nodokotela wakho futhi kanye naye eyolanda ukukhishwa noma umthamo efanele. Musa ukuthatha imithi ku pathologies ezilandelayo:

• Izinkinga adrenal futhi yegilo nezindlala.
• Isimila kwetinhlavu esifundeni gipatalamo-pituitary.
• Hyperprolactinemia.
• Ukwanda usayizi ezikhiqiza amaqanda noma khona izinhlumba ukuthi kungukuthi ezihlobene uphawu amaqanda polycystic.
• ukopha kwesitho sangasese bemvelo engaziwa.
• ukuthuthukiswa okungavamile Izitho zokuzala.
• Lesizalo fibroids, engesiyo iyahambisana abantwana.

• neziqu olunomdlavuza esibelethweni, ezikhiqiza amaqanda, amabele.
• ukuhluleka wesibeletho we esigabeni sokuqala.
• Ukukhulelwa ibele.

Abesilisa weluleka hhayi ukuthatha izidakamizwa "Menopur" (izimpendulo kanye nemiphumela yokwelashwa uqinisekise lesi) ngoba umdlavuza endlaleni engasesinyeni noma kwabanye izimila androgenozavisimyh.

"Menopur" ngoba superovulation

Ngaphambi kokuqhubeka IVF, abesifazane ekunike umuthi ukuthi kuzosiza ukugqugquzela superovulation. Le mithi okuningi, "Diferelin", "Tsetrotid", "Puregon" kanye nabanye abaningi.

"Menopur" ngoba amadoda e-IVF olandelwayo ingenye imithi eminye esebenza ngempumelelo ukuthi luye lwabonisa imiphumela emihle ngemva kokuhlinzwa. Khetha olandelwayo kwesokudla kuzosiza udokotela ngamunye icala ngabanye. Lo chwepheshe ngeke acabangele zonke izifundo bese ukhetha inkambo efanele futhi umthamo ukuthi kuzasiza umphumela omuhle inqubo IVF izikhathi eziningana.

"Menopur" futhi imiphumela engemihle

Ngemuva kokufaka isicelo "Menopur" Izibuyekezo izidakamizwa futhi imiphumela IVF ezimweni eziningi ezinhle, kungenzeka kuwusizo ekuletheni injabulo imikhaya eminingi.

Nokho, kufanele sikhumbule ukuthi libuye libe nemiphumela engemihle:

1. On the ingxenye isimiso sokugaya ukudla bungene: isicanucanu, ukuhlanza kanye ukubuyisa.
2. Kusukela uhlelo endocrine: wesibeletho hyperstimulation syndrome, kukhuphuke izinga le-estrogen excretion emchamweni, ubuhlungu esiswini ephansi. Abesilisa bangezwa gynecomastia.
3. On the ingxenye izinqubo umzimba zomzimba: amahlule, ukwehluleka uketshezi electrolyte, ascites futhi hydrothorax.
4. Ngaphezu kwalokho, phakathi ukwelashwa, iziguli eziningi babonakala kuwukubonakaliswa komzimba, kanye edema kanye ukulunywa kusayithi umjovo.

"Menopur": imiyalelo ezikhethekile ukusetshenziswa

Ngaphambi kokuqala ukwelashwa, njalo nowesifazane indoda kufanele wazi ukuthi kukhona imikhawulo eziningi ukubhuka. Konke lokhu sinikeza ngolwazi olunemininingwane exhunywe nomuthi "Menopur" imiyalelo ukusetshenziswa. Inani (izibuyekezo ukusho njengoba kahle eliphezulu kodwa hhayi eqolo) luyehluka in the ububanzi ruble 1500 umjovo ngamunye. Nokho, izidakamizwa kuyaphumelela futhi bavunyelwe imikhaya eminingi ukuba uthole injabulo yokuba abazali.

Ngaphambi isicelo kubalulekile ukuqeda lesi sifo esincunzayo, noma ukuzabalazela wesibeletho endocrinopathy extragenital.

Futhi, owesifazane ngamunye ochitha ukushukuma "Menopur" (izibuyekezo iziguli agcizelele leli qiniso) kufanele wazi ukuthi umphumela kungaba nokukhulelwa izingane eziningi ngasikhathi.

Uma isiguli wabonisa izimpawu hyperstimulation wesibeletho, ukwelashwa kufanele ngokushesha ayisekho. Lokhu kungase-signal ubuhlungu esiswini, kanye ultrasound. Phakathi ekukhetheni izindlela zokwelapha kuyadingeka nsuku zonke ukuqapha amazinga ama-hormone kanye ultrasound ingabe ekuthuthukiseni follicle.

Uma ukukhulelwa selwenzekile kakade, izimpawu hyperstimulation ngokweqile kungase kwandise kakhulu kanti isiguli waphawula isikhathi eside, kungase ukukhonza njengephayona usongo olukhulu ekuphileni kwakhe.

Phakathi yokwelapha amadoda nge lokuhlushwa eliphezulu FSH egazini, menotropiny ungabonisi imiphumela emihle.

"Menopur": Izibuyekezo

Okwamanje, eziningi abesifazane abakwazi ukukhulelwa ngendlela engokwemvelo, yingakho bavuma IVF, okunikeza ithuba lokuba ingane. Kodwa akukuniki 100% Imiphumela kusukela okokuqala, ngakho kufanele afeze inqubo izikhathi eziningana. Kodwa hhayi wonke owesifazane ithuba, njengoba kubiza kakhulu. Ukuze unike amandla abesifazane ukukhulelwa okokuqala ngenxa yokusizwa yasungulwa izidakamizwa "Menopur" 300 IU. Izibuyekezo kanye nemiphumela yokwelashwa bebelokhu muhle kakhulu. Imithi kwandisa amathuba okuthi ukhulelwe izikhathi eziningana.

Ithuluzi linikeza imiphumela emihle kakhulu emva kokwelashwa, iziguli Izibuyekezo emihle kuphela, into kuphela lokho scares eziningi kubo, ngakho-ke kuba nokukhulelwa izingane eziningi ngasikhathi, okungase kwenzeke ngemuva Yiqiniso yokwelapha "Menopur" izidakamizwa. Kukhona futhi Izimo eziningi side effects, kodwa uma njalo ngaphansi kokuqondisa udokotela ngubani uzoqapha isimo lesiguli kanye ukulawula umthamo, yonke imiphumela engathandeki kuyoba esabekayo.

Sengiphetha, ngifuna ukusho: isifiso sowesifazane ukuba ingane omkhulu ukuze akulungele ukuhamba noma yini oyithandayo, nje ukwazi injabulo ngokuba umama. Ngakho-ke, indlela yokwelapha "Menopur" ngayo yonke imiphumela engemihle akusiyo esabekayo. Kodwa kuwufanele ukukhumbula ukuthi isinqumo ngokuphamazela kanye nokusetshenziswa engalawuliwe izidakamizwa kungaholela emiphumeleni engathí sina kakhulu futhi ungalungiseki. Kuphela udokotela kufanele kube nowesifazane kudlule ngale ndlela futhi benza konke abangakwenza ukuze uthole umphumela omuhle.