"Chloride Suxamethonium": incazelo izinto, ohlangothini-imiphumela kanye nokubuyekeza

Zokwelapha, izinhlobo eziningi zezidakamizwa edingekayo, isib, ukuletha umzimba lesiguli kusimo adingekayo ukuhlinzwa umkhiqizo. izinqubo ezithile zidinga eyayenziwe sokucasuka ukuphumula ngokuphelele kwemisipha. Ngenxa yale njongo, ukusetshenziswa ngokuvamile kuba izidakamizwa "suxamethonium chloride" (egameni lendawo yokuhweba noma umkhiqizo - "Listeon"). Lesi sidakamizwa ikakhulukazi esetshenziswa ezikhungweni zokwelapha ezikhethekile. Yini luwumgogodla wesenzo kwemithi? Ingabe kuyingozi ukusebenzisa izimali? Yini okufanele uzilungiselele nokusetshenziswa ketshezi "suxamethonium chloride"? Incazelo nokulungiselela ezinye izici isicelo yayo Kamuva sizoxoxa ngokuthi kulesi sihloko.

isakhiwo

The main izidakamizwa esebenzayo ekulungisweni kubhekwa chloride suxamethonium. Futhi nomuthi kuhlanganisa izingxenye asizayo ezifana sodium chloride, ethylenediaminetetraacetic acid disodium usawoti (Trilon B), noma disodium edetate, namanzi umjovo.

ukukhululwa Ifomu

"Suxamethonium chloride" kuvame ekhiqizwa yizimboni ngesimo isixazululo (kokubili esicutshini futhi ngomjovo).

imiphumela kwemithi

nomuthi Kubhekwe is depolarizing imisipha relaxant. isenzo sayo sifushane. Izingxenye asebenzayo zomuthi ngempumelelo okuvimba ukudluliswa kwamanyuroni.

Miorelaxation njalo zenzeka ukulandelana efanayo, kubalulekile ukuba acabangele abasebenzi bezokwelapha. Ngakho, kuthathela imisipha ubudala, eminye kuthinta imisipha masticatory futhi imisipha iminwe, amehlo kanye nazo zonke izitho. Khona-ke muscle ifinyelela entanyeni, imisipha ngemuva, isisu, yezwi. Popular basabela isenzo zomuthi imisipha intercostal kanye diaphragm.

Uma izidakamizwa saphathwa intramuscularly, ke zizosebenza ngemuva ezimbili - imizuzu emine, futhi uma emthanjeni - emva imizuzu embalwa. Maximum muscle kwenzeka kungakapheli imizuzu emithathu ngemuva izidakamizwa abaphathi. Lo mphumela ihlala emihlanu - kwemizuzu eyishumi, lokhu kuncike umthamo we ketshezi.

Umuthi is nombala basakaza yi-plasma yegazi kanye uketshezi extracellular ngokushesha ngemva kokuphathwa yesixazululo (enikeziwe ekuphathweni ngomjovo). Cishe ayisishiyagalolunye amaphesenti hydrolyzed izidakamizwa, waliguqula ku choline noma succinic acid. Kuncike ekutheni lokuhlushwa cholinesterase egazini kugcinwa ezingeni eyanele, nenxenye impilo umuthi imizuzwana ayisishiyagalolunye kuphela. Ingqikithi ngokugcwele excreted ngu izinso (kuhlanganise amaphesenti ayishumi - akushintshiwe).

izinkomba

Kubhekwe umuthi esetshenziswa ezimweni lapho kuyadingeka ukwenza kokungenela edinga ephelele muscle. Izimo ezinjalo zihlanganisa bronchoscopy, Endoscopy, abdominanlnye operation kabusha waphuka, dislocations ukunciphisa kanye endotracheal intubation.

nokushintsha kokudla nokufakwa

Into "suxamethonium chloride" ingasatshenziswa ngemithambo yegazi futhi intramuscularly (njengoba drip noma bolus). Ukuze uthole indlela enjalo isicelo usebenzisa 0.1% isixazululo lomcebo. Ukusebenza umthamo lapho i chloride suxamethonium futhi iodide, uchwepheshe ngamunye ayabelwe ngokuhambisana izici ngamunye isiguli esithile, futhi ngokuvamile, lapho zaphathwa ngemithambo yegazi isukela 0.1 kuya 2 angu kilogram per, futhi esicutshini - kusuka 3 kuya 4 micrograms ngayinye kg. Ngo yonke inkambo ukwelashwa umthamo isamba impahla akufanele idlule ngayikhulu namashumi ayisihlanu micrograms.

Izimo

Ezinye iziguli hhayi kunoma isiphi isimo ongase ufakwe ukulungiselela "suxamethonium chloride". Iziyalezo ukusetshenziswa ngokuvumelana Izimo ezilandelayo ukusetshenziswa zomuthi izidakamizwa: hypersensitivity ngabanye kunoma izithako we nomuthi, myasthenia gravis, isifuba somoya bronchial, engela-Ukuvalwa ukufiphala edema yamaphaphu, hyperkalemia, komzimba abulalayo, acute esingamahlalakhona hepatic, uyisithulu futhi dystrophic myotonia, ukuntuleka cholinesterase, Duchenne muscular dystrophy, mechanical iso ukulimala. Futhi kubhekwe banqatshelwe usebenzisa izidakamizwa ukuze izingane ezingaphansi konyaka futhi abesifazane ngesikhathi ukuzalwa noma ukuncelisa ibele.

side effects

Ezimweni ezingavamile, "suxamethonium chloride" (Isixazululo for umjovo) kungabangela eziningi izimpawu kabi kusuka kumasistimu ezihlukahlukene zomzimba. Phakathi kwalezi izinhlobo komzimba (isib bronchospasm futhi ukushaqeka anaphylactic), ukukhubazeka kwemisipha yokuphefumula (kwenzeka uma kukhona izifo ezibangelwa ufuzo kwetinhlavu serum cholinesterase), arrhythmia, myalgia, imfiva, bradycardia, hyperkalemia, nokugxaza amathe, ukushaqeka cardiogenic, ukwehlisa umfutho wegazi, conduction kwezinso, waqinisa intraocular. Ukuze ugweme izinkinga ngenhla kubalulekile ngokuqinile ulandele izincomo ukusetshenziswa kwezidakamizwa "suxamethonium chloride." Izidakamizwa analogue (okungenani ezinye zazo) unezindawo ezimbalwa kude engemihle. Ngakho-ke, ngezinye izikhathi kuyoba ezinengqondo ukusisebenzisa kubo.

ukweqisa izidakamizwa

Endabeni le esingeqile umthamo ongahlosile noma ngamabomu Kunconywa kungenzeka abanye nemiphumela engathandeki isiguli. I esiyingozi kakhulu sazo ukumisa ukuphefumula. Kulokhu ngaphandle kosizo ochwepheshe abakwazi ukwenza ngenye indlela kungaholela ekufeni. Udinga ukupholisa esiphuthumayo. Ngezinye izikhathi cholinesterase serum ezingeni lwehla. Abanye ochwepheshe batusa ukuba aphathe lesi simo noma ukumpontshelwa igazi fresh, okuyinto ngokuvamile ephephile engazweli esikhundleni.

imiyalelo ezikhethekile

Kunconywa ukwethula eliphezulu non-depolarizing imisipha relaxants umzuzu ngaphambi izidakamizwa isimiso sokuqondisa 'suxamethonium chloride. " Incazelo impahla iqukethe ulwazi nokuxhumana okunjalo aqede ingozi ukuthuthukiswa alandelayo myalgia futhi imisipha twitches. Kubalulekile ukusebenzisa izidakamizwa kuphela eminyangweni ezikhethekile ezikhungweni zezempilo, kuncike ukutholakala impahla edingekayo (kufaka apharathasi ngoba umuntu afakwe emishinini yokuphefumula) kanye nabasebenzi abanekhono ukwazi ukusebenzisa kahle le ndlela nokwenza izinqumo ezimweni ezicindezelayo. Njengoba isicelo kubhekwe izindlela kungadala bradycardia nesineke, kutuswa ukwethula izidakamizwa isiguli "atropine" ngaphambi kokusebenzisa "suxamethonium chloride".

Zingahlanganiswa nezinye ukuthaka imithi ngendlela

Uma usebenzisa neminye imithi ngesikhathi esifanayo kubhekwe izidakamizwa kufanele sinake ukuthi ukuxhumana okunjalo uvunyelwe. "Suxamethonium chloride" imfundo manual alikukhuthazi usebenzisa parallel antimiastenicheskimi amalungiselelo njengoba iyehlisa ukusebenza yezenzo zabo. nomuthi Kubhekwe sijulisa imiphumela zemithi glycosides. Kunoma ikuphi ayikwazi ukusetshenziswa "chloride suxamethonium" kanyekanye ngegazi donor, njengoba ingqondo hydrolysis ukuphendula, noma iyiphi imikhiqizo yegazi, izixazululo alikhali futhi izixazululo we barbiturates (ikhuthaza kwenze).

Umthelela ekhonweni ukuba agxilise (ukushayela futhi izakhi eziyinkimbinkimbi)

"Suxamethonium chloride" has nomthelela obalulekile ikhono ukugxila futhi silondoloze ukunakwa. Lokhu kusho ukuthi ukuze ugweme izingozi ukugwema ukushayela futhi yimiphi eminye imisebenzi ukuthi usongo ekuphileni nasempilweni yabantu futhi zidinga emakamu eliphezulu futhi ukusabela okusheshayo futhi osheshayo ekuthathweni ngosuku lokuqala ngemva kokuqedwa zomuthi kubhekwe.

izimo Isitoreji eshalofini yokuphila

Isitolo "suxamethonium chloride" kungaba ngaphansi kwezimo ngokuqinile echaziwe. Okungukuthi, ngaleso lokushisa isitoreji kufanele isukela ezimbili kuya kweziyisishiyagalombili degrees Celsius. Umuthi kumele ibekwe ngaphandle kwendawo etholakalayo izingane. Umkhawulo eshalofini yokuphila zomuthi sekuyiminyaka emithathu kusukela ngosuku womshini. Emva kwalesi sikhathi ukusetshenziswa kwezidakamizwa is hhayi Kunconywa, ngoba kulesi simo nje leyo ndawo ilahlekelwa impahla yayo futhi kuzuzise kungaba yingozi ukuze isiguli.

ukuphepha isiguli, ukuphepha ukuphila kwakhe - ke kungumsebenzi odokotela abenza nokwelashwa kwayo. Ngakho-ke, kubalulekile ukuthi abaholi nezikhungo zezokwelapha anakekela nobhoko kulezi zikhungo abanolwazi isicelo izidakamizwa, imiphumela emibi lezi zimali, izindlela yokuqeda iyiphi ukusabela ezingezinhle. Ngokufanayo, abasebenzi esibhedlela kufanele engenalo ulwazi oludingekayo kanye namakhono ukusebenzisa kahle imishini etholakalayo engasindisa ukuphila isiguli. Lokhu kusebenza ikakhulukazi ukuba amalungiselelo side effects kabani ezingaba ezingase zisongele ukuqala ukufa. Kuyinto kuleli qembu izidakamizwa zihlanganisa "suxamethonium chloride." Ngakho-ke, kufanele lisetshenziswe kuphela uma kwenzeka ukuthi ngesikhathi inqubo kukhona ochwepheshe abanekhono JavaScript ukuze usebenzise womoya-mpilo. Lokhu kungase kudingeke lapho ukusabela ecaleni ezifana ukuboshwa zokuphefumula. Kulokhu, kusebentisana izenzo odokotela zamakhono babo bomsebenzi kuyoba izici kubalulekile ukuthi ukunquma ukuthi isiguli bayosinda.

Ngezinye izikhathi odokotela ngasizathu simbe (uma kukhona ezinye Izimo) unquma ukusebenzisa relaxant kwemisipha - analog "suxamethonium chloride" (isib, "Ditilin" esingenakubalwa zisetshenziswe kuphela khona-glaucoma). Kubalulekile uthemba umbono eliyigunya ochwepheshe ngalolu daba. Ngakho-ke, kufanele siqiniseke sekhono professional odokotela nobani sebenzisana.

Ngaphambi kokuthi ukhethe i ekwenziweni nezanamuhla kufanele sifunde konke mayelana daba "suxamethonium chloride": igama ezohwebo, analogs, Izimo, imiphumela engemihle, ukusetshenziswa, kanye umthamo Kunconywa. Isiguli Kumelwe ufunde nokuthi izindophi yilokhu uhlobo imithi waye uDavide esenza okusesikweni. "Listenon" ( "chloride suxamethonium") - lo egameni lendawo yokuhweba noma into mbuzo. Ngakho-ke, uma uzwa kusukela izindebe leli gama udokotela, uzobe kahle kanjani uyokwenza umzimba wakho. Lolu lwazi kuyadingeka ukuze agweme ukufaka ukuphila kwabo engozini ngokungadingekile ngokuhlinzwa. Kubalulekile ukuba njengoba ngokucophelela njengoba lokho imithi wena yethulwe ekwelapheni.

Themba impilo yakho kuphela ochwepheshe, ukhethe impatho esezingeni futhi imikhiqizo engcono! Zinakekele!